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Whereas examples of regional immunity are known in other mucosal epithelia, to date, no immune microenvironments have been described in the nasal mucosa, a site where the complex functions of olfaction and immunity need to be orchestrated. In this study we identified the presence of CD8\u03b1+ cells in the rainbow trout (Oncorhynchus mykiss) nasal epithelium. Nasal CD8\u03b1+ cells display a distinct phenotype suggestive of CD8+ T cells with high integrin \u03b22 expression. Importantly, nasal CD8\u03b1+ cells are located in clusters at the mucosal tip of each olfactory lamella but scattered in the neuroepithelial region. The grouping of CD8\u03b1+ cells may be explained by the greater expression of CCL19, ICAM-1, and VCAM-1 in the mucosal tip compared with the neuroepithelium. Whereas viral Ag uptake occurred via both tip and lateral routes, tip-resident MHC class II+ cells are located significantly closer to the lumen of the nasal cavity than are their neuroepithelial counterparts, therefore having quicker access to invading pathogens. Our studies reveal compartmentalized mucosal immune responses within the nasal mucosa of a vertebrate species, a strategy that likely optimizes local immune responses while protecting olfactory sensory functions.<\/jats:p>","DOI":"10.4049\/jimmunol.1600678","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T01:40:24Z","timestamp":1477532424000},"page":"4453-4463","source":"Crossref","is-referenced-by-count":36,"title":["Tissue Microenvironments in the Nasal Epithelium of Rainbow Trout (<i>Oncorhynchus mykiss<\/i>) Define Two Distinct CD8\u03b1+ Cell Populations and Establish Regional Immunity"],"prefix":"10.1093","volume":"197","author":[{"given":"Ali","family":"Sepahi","sequence":"first","affiliation":[{"name":"Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico , Albuquerque, NM 87131"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Casadei","sequence":"additional","affiliation":[{"name":"Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico , Albuquerque, NM 87131"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Tacchi","sequence":"additional","affiliation":[{"name":"Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico , Albuquerque, NM 87131"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Sanidad Animal, Facultad de Veterinaria, Campus de Excelencia Internacional Regional Campus Mare Nostrum, Universidad de Murcia , 30100 Murcia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E","family":"LaPatra","sequence":"additional","affiliation":[{"name":"Clear Springs Foods Research Division , Buhl, ID 83316"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Salinas","sequence":"additional","affiliation":[{"name":"Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico , Albuquerque, NM 87131"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"2025030618355397500_r1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1057","article-title":"Anatomical basis of tolerance and immunity to intestinal antigens","volume":"3","author":"Mowat","year":"2003","journal-title":"Nat. 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