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We found that infection with Leishmania major increases the expression of vascular endothelial growth factor-A and vascular endothelial growth factor receptor (VEGFR)-2 and is associated with significant changes in the blood and lymphatic vasculature at the site of infection. Ab blockade of VEGFR-2 during infection led to a reduction in lymphatic endothelial cell proliferation and simultaneously increased lesion size without altering the parasite burden. These data show that L. major infection initiates enhanced vascular endothelial growth factor-A\/VEGFR-2 signaling and suggest that VEGFR-2-dependent lymphangiogenesis is a mechanism that restricts tissue inflammation in leishmaniasis.<\/jats:p>","DOI":"10.4049\/jimmunol.1600717","type":"journal-article","created":{"date-parts":[[2016,7,30]],"date-time":"2016-07-30T01:39:46Z","timestamp":1469842786000},"page":"1823-1831","source":"Crossref","is-referenced-by-count":45,"title":["<i>Leishmania major<\/i> Infection\u2013Induced VEGF-A\/VEGFR-2 Signaling Promotes Lymphangiogenesis That Controls Disease"],"prefix":"10.1093","volume":"197","author":[{"given":"Tiffany","family":"Weinkopff","sequence":"first","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Konradt","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Christian","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E","family":"Discher","sequence":"additional","affiliation":[{"name":"Biophysical Eng\u2019g Labs, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"2025030617475612400_r1","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/S0190-9622(94)70229-2","article-title":"Treatment of cutaneous leishmaniasis","volume":"31","author":"Koff","year":"1994","journal-title":"J. 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