{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:19:43Z","timestamp":1778746783573,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Epidermal \u03b3\u03b4 T cells that reside in the front line of the skin play a pivotal role in stress immune surveillance. However, it is not clear whether these cells are involved in further induction of immune responses after they are activated in dysregulated epidermis. In this study, we found that activated \u03b3\u03b4 T cells expressed occludin and migrated into draining lymph nodes in an occludin-dependent manner. Epidermal \u03b3\u03b4 T cells in occludin-deficient mice exhibited impairments in morphology changes and motility, although they expressed activation markers at levels comparable to those in wild-type cells. Occludin deficiency weakened the induction of allergen-induced contact hypersensitivity, primarily as the result of the impaired migration of epidermal \u03b3\u03b4 T cells. Thus, occludin expression by epidermal \u03b3\u03b4 T cells upon activation in response to epidermal stress allows them to move, which could be important for augmentation of immune responses via collaboration with other cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1600848","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:50:17Z","timestamp":1496278217000},"page":"62-71","source":"Crossref","is-referenced-by-count":15,"title":["Occludin Expression in Epidermal \u03b3\u03b4 T Cells in Response to Epidermal Stress Causes Them To Migrate into Draining Lymph Nodes"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3499-9900","authenticated-orcid":false,"given":"Takahito","family":"Saito","sequence":"first","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaro","family":"Ohki","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Tomura","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Osaka Ohtani University , Osaka 584-8541,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,7,1]]},"reference":[{"key":"2025030612063126500_r1","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.4049\/jimmunol.172.6.3573","article-title":"A keratinocyte-responsive \u03b3 \u03b4 TCR is necessary for dendritic epidermal T cell activation by damaged keratinocytes and maintenance in the epidermis","volume":"172","author":"Jameson","year":"2004","journal-title":"J. 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