{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:34:31Z","timestamp":1790174071273,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In rheumatoid arthritis (RA), cartilage and bone matrix are degraded, and extracellular matrix (ECM) proteins, acting as cellular activators, are liberated. Similar to ECM proteins, matrix-bound chemokines, cytokines, and growth factors (GFs) influence functional properties of key cells in RA, especially synovial fibroblasts. The role of these molecules on attachment, migration, and proinflammatory and prodestructive activation of RASFs was analyzed. Adhesion\/migration of RASFs were examined under GF-enriched (GF+) or \u2013reduced (GF\u2212) conditions with or without addition of matrix-associated GFs, TGF-\u03b2, and platelet-derived GF to GF\u2212 or culture supernatants. Fibroblast adhesion and alterations in proinflammatory\/prodestructive properties (e.g., IL-6\/matrix metalloproteinase 3-release) in response to matrix-associated molecules were compared. Effects of GF+, GF\u2212, and other ECM components on human RASF-mediated cartilage invasion were examined in the SCID mouse model. RASF adhesion under GF\u2212 conditions was significantly lower compared with GF+ conditions (6.8- versus 8.3-fold). This effect was specific for RA because control cells showed opposite effects (e.g., osteoarthritis synovial fibroblasts [SF]; GF\u2212 versus GF+: 10.7- versus 8-fold). Addition of TGF-\u03b2 to GF\u2212 increased RASF attachment (12.7-fold) compared with other matrices and components. RASF adhesion to GF+ matrix resulted in the strongest IL-6 and matrix metalloproteinase-3 release, and was even more pronounced compared with supplementation of single GFs. In vivo, GF\u2212 matrix decreased RASF-mediated cartilage invasion compared with GF+ matrix. ECM components and especially GFs when bound within ECM actively enhance RASF attraction and cartilage adhesion. This observation was specific for RASFs as a reverse behavior was observed for controls.<\/jats:p>","DOI":"10.4049\/jimmunol.1600989","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T00:40:25Z","timestamp":1494636025000},"page":"4588-4595","source":"Crossref","is-referenced-by-count":23,"title":["Disease-Specific Effects of Matrix and Growth Factors on Adhesion and Migration of Rheumatoid Synovial Fibroblasts"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3497-1011","authenticated-orcid":false,"given":"Stephanie","family":"Lef\u00e8vre","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff Clinic , 61231 Bad Nauheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff Clinic , 61231 Bad Nauheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian M P","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff Clinic , 61231 Bad Nauheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1034-6657","authenticated-orcid":false,"given":"Birgit","family":"Zimmermann-Geller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff Clinic , 61231 Bad Nauheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo H","family":"Tarner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff Clinic , 61231 Bad Nauheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7681-9918","authenticated-orcid":false,"given":"Markus","family":"Rickert","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Orthopaedic Surgery, University Hospital Giessen and Marburg , 35392 Giessen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Steinmeyer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Orthopaedic Surgery, University Hospital Giessen and Marburg , 35392 Giessen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sauerbier","sequence":"additional","affiliation":[{"name":"Department of Plastic, Hand and Reconstructive Surgery, BG Trauma Center , 60389 Frankfurt,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rehart","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, Agaplesion Markus-Hospital , 60431 Frankfurt,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"M\u00fcller-Ladner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff Clinic , 61231 Bad Nauheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff Clinic , 61231 Bad Nauheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"2025030615165085300_r1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol. 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