{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:07:25Z","timestamp":1768421245498,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>With enhanced concerns of terrorist attacks, dual exposure to radiation and thermal combined injury (RCI) has become a real threat with devastating immunosuppression. NLRP12, a member of the NOD-like receptor family, is expressed in myeloid and bone marrow cells and was implicated as a checkpoint regulator of inflammatory cytokines, as well as an inflammasome activator. We show that NLRP12 has a profound impact on hematopoietic recovery during RCI by serving as a checkpoint of TNF signaling and preventing hematopoietic apoptosis. Using a mouse model of RCI, increased NLRP12 expression was detected in target tissues. Nlrp12\u2212\/\u2212 mice exhibited significantly greater mortality, an inability to fight bacterial infection, heightened levels of proinflammatory cytokines, overt granulocyte\/monocyte progenitor cell apoptosis, and failure to reconstitute peripheral myeloid populations. Anti-TNF Ab administration improved peripheral immune recovery. These data suggest that NLRP12 is essential for survival after RCI by regulating myelopoiesis and immune reconstitution.<\/jats:p>","DOI":"10.4049\/jimmunol.1601048","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T01:10:46Z","timestamp":1486170646000},"page":"2426-2433","source":"Crossref","is-referenced-by-count":20,"title":["Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-1837","authenticated-orcid":false,"given":"Brandon M L","family":"Linz","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal J","family":"Neely","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel B","family":"Kartchner","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"April E","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-7167","authenticated-orcid":false,"given":"Amal L","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Truax","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-6594","authenticated-orcid":false,"given":"Gregory","family":"Sempowski","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute, Duke University , Durham, NC 27708"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Eitas","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"},{"name":"Host Defense Discovery Performance Unit, GlaxoSmithKline , Research Triangle Park, NC 27709"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June","family":"Brickey","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-0395","authenticated-orcid":false,"given":"Jenny P Y","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A","family":"Cairns","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"},{"name":"Department of Surgery, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9126-4188","authenticated-orcid":false,"given":"Robert","family":"Maile","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"},{"name":"Department of Surgery, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"2025030615051046300_r1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.it.2010.12.003","article-title":"Inflammatory signals regulate hematopoietic stem cells","volume":"32","author":"Baldridge","year":"2011","journal-title":"Trends Immunol."},{"key":"2025030615051046300_r2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nri3660","article-title":"Emergency granulopoiesis","volume":"14","author":"Manz","year":"2014","journal-title":"Nat. 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