{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:42:12Z","timestamp":1790638932579,"version":"4.1.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1), which accumulates in mammalian host organisms during infection, supports the defense against microbial pathogens. However, whether and to what extent HIF-1\u03b1 expressed by myeloid cells contributes to the innate immune response against Leishmania major parasites is unknown. We observed that Leishmania-infected humans and L. major\u2013infected C57BL\/6 mice exhibited substantial amounts of HIF-1\u03b1 in acute cutaneous lesions. In vitro, HIF-1\u03b1 was required for leishmanicidal activity and high-level NO production by IFN-\u03b3\/LPS-activated macrophages. Mice deficient for HIF-1\u03b1 in their myeloid cell compartment had a more severe clinical course of infection and increased parasite burden in the skin lesions compared with wild-type controls. These findings were paralleled by reduced expression of type 2 NO synthase by lesional CD11b+ cells. Together, these data illustrate that HIF-1\u03b1 is required for optimal innate leishmanicidal immune responses and, thereby, contributes to the cure of cutaneous leishmaniasis.<\/jats:p>","DOI":"10.4049\/jimmunol.1601080","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T20:12:50Z","timestamp":1476821570000},"page":"4034-4041","source":"Crossref","is-referenced-by-count":56,"title":["Myeloid Cell\u2013Derived HIF-1\u03b1 Promotes Control of <i>Leishmania major<\/i>"],"prefix":"10.1093","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7784-8753","authenticated-orcid":false,"given":"Valentin","family":"Schatz","sequence":"first","affiliation":[{"name":"Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg, University of Regensburg , 93053 Regensburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8679-4862","authenticated-orcid":false,"given":"Yannic","family":"Str\u00fcssmann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg, University of Regensburg , 93053 Regensburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Mahnke","sequence":"additional","affiliation":[{"name":"Mikrobiologisches Institut, Klinische Mikrobiologie, Immunologie, und Hygiene, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Schley","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 4, Nephrologie und Hypertensiologie, Universit\u00e4tsklinikum Erlangen, 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Frankfurt,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"McNiff","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yale University School of Medicine , New Haven, CT 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar R","family":"Colegio","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yale University School of Medicine , New Haven, CT 06510"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bogdan","sequence":"additional","affiliation":[{"name":"Mikrobiologisches Institut, Klinische Mikrobiologie, Immunologie, und Hygiene, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , 91054 Erlangen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Jantsch","sequence":"additional","affiliation":[{"name":"Institute of 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