{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T21:39:15Z","timestamp":1774042755716,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Many chronic liver disorders are characterized by dysregulated immune responses and hepatocyte death. We used an in vivo model to study the immune response to necrotic liver injury and found that necrotic liver cells induced eosinophil recruitment. Necrotic liver induced eosinophil IL-1\u03b2 and IL-18 secretion, degranulation, and cell death. Caspase-1 inhibitors blocked all of these responses. Caspase-1\u2013mediated cell death with accompanying cytokine release is the hallmark of a novel form of cell death termed pyroptosis. To confirm this response in a disease model, we isolated eosinophils from the livers of Schistosoma mansoni\u2013infected mice. S. mansoni eggs lodge in the hepatic sinusoids of infected mice, resulting in hepatocyte death, inflammation, and progressive liver fibrosis. This response is typified by massive eosinophilia, and we were able to confirm pyroptosis in the infiltrating eosinophils. This demonstrated that pyroptosis is a cellular pathway used by eosinophils in response to large-scale hepatic cell death.<\/jats:p>","DOI":"10.4049\/jimmunol.1601162","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:35:13Z","timestamp":1498523713000},"page":"847-853","source":"Crossref","is-referenced-by-count":29,"title":["Cutting Edge: Eosinophils Undergo Caspase-1\u2013Mediated Pyroptosis in Response to Necrotic Liver Cells"],"prefix":"10.1093","volume":"199","author":[{"given":"Daphne","family":"Palacios-Macapagal","sequence":"first","affiliation":[{"name":"MedImmune , Gaithersburg, MD 20878"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Connor","sequence":"additional","affiliation":[{"name":"MedImmune , Gaithersburg, MD 20878"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Mustelin","sequence":"additional","affiliation":[{"name":"MedImmune , Gaithersburg, MD 20878"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thirumalai R","family":"Ramalingam","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7244-8731","authenticated-orcid":false,"given":"Thomas A","family":"Wynn","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd S","family":"Davidson","sequence":"additional","affiliation":[{"name":"MedImmune , Gaithersburg, MD 20878"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,8,1]]},"reference":[{"key":"2025030614205419500_r1","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1097\/00007890-199805270-00009","article-title":"Monitoring eosinophil activation and liver function after liver transplantation","volume":"65","author":"Hughes","year":"1998","journal-title":"Transplantation"},{"key":"2025030614205419500_r2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/hep.1840200317","article-title":"The eosinophil as an effector cell of the immune response during hepatic allograft rejection","volume":"20","author":"de Groen","year":"1994","journal-title":"Hepatology"},{"key":"2025030614205419500_r3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.pathmechdis.3.121806.151456","article-title":"The inflammatory response to cell death","volume":"3","author":"Rock","year":"2008","journal-title":"Annu. 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