{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:23:41Z","timestamp":1790421821023,"version":"4.1.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Congenital CMV infection (cCMV) is the most common congenital infection that can cause long-term impairment (LTI). The pathogenesis of LTI is not completely understood. Fetal immunity may play a role in controlling the infection and preventing LTI, although immune activation may also contribute to fetal immunopathology. In this study, we analyzed various molecular markers of T and B cell numbers in neonatal dried blood spots of 99 children with cCMV and 54 children without cCMV: \u03b4Rec-\u03c8J\u03b1 signal joints on TCR excision circles, intron recombination signal sequence k-deleting element signal joints on Ig\u03ba-deleting recombination excision circles, genomic intron recombination signal sequence k-deleting element coding joint, genomic V\u03b41-J\u03b41, and V\u03b42-J\u03b41 rearrangements. Of this cohort, clinical symptoms at birth and LTI at 6 y of age were recorded. Neonates with cCMV had fewer TCR excision circles in their blood than non-infected controls. Furthermore, cCMV infection was associated with increased numbers of \u03b3\u03b4 T cells and B cells, and these numbers were positively correlated with CMV viral load in the dried blood spots. Infected children with a better long-term outcome had higher numbers of B cells at birth than those who developed LTI; no difference in B cell replication was observed. The potential protective role of B cells in controlling cCMV-related disease and the clinical value of this marker as a predictor of long-term outcome merit further evaluation.<\/jats:p>","DOI":"10.4049\/jimmunol.1601182","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T03:00:20Z","timestamp":1480561220000},"page":"102-109","source":"Crossref","is-referenced-by-count":16,"title":["T and B Cell Markers in Dried Blood Spots of Neonates with Congenital Cytomegalovirus Infection: B Cell Numbers at Birth Are Associated with Long-Term Outcomes"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-844X","authenticated-orcid":false,"given":"Roberta","family":"Rovito","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Leiden University Medical Center , 2333 ZA Leiden,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein J","family":"Korndewal","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Leiden University Medical Center , 2333 ZA Leiden,","place":["the Netherlands"]},{"name":"Centre for Infectious Diseases, Epidemiology and Surveillance, National Institute of Public Health and the Environment , 3720 BA, Bilthoven,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4161-1919","authenticated-orcid":false,"given":"Menno C","family":"van Zelm","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathology, Central Clinical School, Monash University , Melbourne, VIC 3800,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Ziagkos","sequence":"additional","affiliation":[{"name":"Medical Statistics and Bioinformatics, Leiden University Medical Center , 2333 ZA Leiden,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Wessels","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Leiden University Medical Center , 2333 ZA Leiden,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-3104","authenticated-orcid":false,"given":"Mirjam","family":"van der Burg","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus MC University Medical Centre Rotterdam , 3015 CN, Rotterdam,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aloys C M","family":"Kroes","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Leiden University Medical Center , 2333 ZA Leiden,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2078-3220","authenticated-orcid":false,"given":"Anton W","family":"Langerak","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus MC University Medical Centre Rotterdam , 3015 CN, Rotterdam,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1750-2843","authenticated-orcid":false,"given":"Ann C T M","family":"Vossen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Leiden University Medical Center , 2333 ZA Leiden,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2025030614560044400_r1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/rmv.544","article-title":"New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection","volume":"17","author":"Dollard","year":"2007","journal-title":"Rev. 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