{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:44:29Z","timestamp":1791830669473,"version":"4.3.4"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sepsis is a severe and complicated syndrome that is characterized by dysregulation of host inflammatory responses and organ failure, with high morbidity and mortality. The literature implies that autophagy is a crucial regulator of inflammation in sepsis. In this article, we report that autophagy-related protein 7 (Atg7) is involved in inflammasome activation in Pseudomonas aeruginosa abdominal infection. Following i.p. challenge with P. aeruginosa, atg7fl\/fl mice showed impaired pathogen clearance, decreased survival, and widespread dissemination of bacteria into the blood and lung tissue compared with wild-type mice. The septic atg7fl\/fl mice also exhibited elevated neutrophil infiltration and severe lung injury. Loss of Atg7 resulted in increased production of IL-1\u03b2 and pyroptosis, consistent with enhanced inflammasome activation. Furthermore, we demonstrated that P. aeruginosa flagellin is a chief trigger of inflammasome activation in the sepsis model. Collectively, our results provide insight into innate immunity and inflammasome activation in sepsis.<\/jats:p>","DOI":"10.4049\/jimmunol.1601196","type":"journal-article","created":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T01:50:20Z","timestamp":1488592220000},"page":"3205-3213","source":"Crossref","is-referenced-by-count":160,"title":["Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in <i>Pseudomonas<\/i> Sepsis"],"prefix":"10.1093","volume":"198","author":[{"given":"Qinqin","family":"Pu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["People\u2019s Republic of China"]},{"name":"Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota , Grand Forks, ND 58203"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changpei","family":"Gan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["People\u2019s Republic of China"]},{"name":"Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota , Grand Forks, ND 58203"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota , Grand Forks, ND 58203"},{"name":"Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province, Jiangsu Normal University , Xuzhou, Jiangsu 221116,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["People\u2019s Republic of 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West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lefu","family":"Lan","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Pudong Xinqu , Shanghai Shi 201203,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, City University of Hong Kong , Kowloon Tong,","place":["Hong Kong"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University , Xi\u2019an, ShangXi 710069,","place":["People\u2019s Republic of 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