{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:18:38Z","timestamp":1790036318114,"version":"4.0.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with systemic lupus erythematosus exhibit accelerated atherosclerosis, a chronic inflammatory disease of the arterial wall. The impact of B cells in atherosclerosis is controversial, with both protective and pathogenic roles described. For example, natural IgM binding conserved oxidized lipid epitopes protect against atherosclerosis, whereas anti-oxidized low-density lipoprotein (oxLDL) IgG likely promotes disease. Because BAFF promotes B cell class-switch recombination and humoral autoimmunity, we hypothesized that excess BAFF would accelerate atherosclerosis. In contrast, BAFF overexpression markedly reduced hypercholesterolemia and atherosclerosis in hyperlipidemic mice. BAFF-mediated atheroprotection required B cells and was associated with increased protective anti-oxLDL IgM. Surprisingly, high\u2013titer anti-oxLDL IgM production and reduced atherosclerosis was dependent on the BAFF family receptor transmembrane activator and CAML interactor. In summary, we identified a novel role for B cell\u2013specific, BAFF-dependent transmembrane activator and CAML interactor signals in atherosclerosis pathogenesis, of particular relevance to the use of BAFF-targeted therapies in systemic lupus erythematosus.<\/jats:p>","DOI":"10.4049\/jimmunol.1601198","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T22:44:19Z","timestamp":1478904259000},"page":"4529-4534","source":"Crossref","is-referenced-by-count":49,"title":["Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation"],"prefix":"10.1093","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7024-5252","authenticated-orcid":false,"given":"Shaun W","family":"Jackson","sequence":"first","affiliation":[{"name":"Seattle Children\u2019s Research Institute , Seattle, WA 98101"},{"name":"Department of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole E","family":"Scharping","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute , Seattle, WA 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3250-8258","authenticated-orcid":false,"given":"Holly M","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute , Seattle, WA 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Chait","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0810-1776","authenticated-orcid":false,"given":"David J","family":"Rawlings","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute , Seattle, WA 98101"},{"name":"Department of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Department of Immunology, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"key":"2025030618360964500_r1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nri2415","article-title":"The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models","volume":"8","author":"Weber","year":"2008","journal-title":"Nat. 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