{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:04:20Z","timestamp":1790435060550,"version":"4.1.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Immune mechanisms responsible for pathogen clearance from the female reproductive tract (FRT) are incompletely defined; in particular, the contribution of lymphocyte trafficking to this process is unclear. CCR7-deficient mice have profoundly altered lymphocyte recirculation and display ectopic formation of lymphocyte aggregates within mucosal nonlymphoid tissues, including the FRT. In this study, we investigated how altered lymphocyte distribution in CCR7-deficient mice would affect host responses to Chlamydia muridarum within the reproductive tract. As expected, CCR7-deficient mice exhibited reduced lymphocyte trafficking to lymph nodes and a corresponding increase in T cell populations within the FRT. After intravaginal infection with Chlamydia, CCR7-deficient mice displayed markedly reduced Ag-specific CD4 T cell responses within the local draining iliac lymph nodes, yet robust Th1 and Th17 responses were prominent in the FRT. In addition, Chlamydia-specific Ab responses were dysregulated in CCR7-deficient mice, displaying an unexpected increase in the systemic IgA responses. Importantly, prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT while reducing tissue-associated inflammation and pathology. Thus, increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology.<\/jats:p>","DOI":"10.4049\/jimmunol.1601314","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T00:30:17Z","timestamp":1502497817000},"page":"2547-2554","source":"Crossref","is-referenced-by-count":11,"title":["CCR7 Deficiency Allows Accelerated Clearance of <i>Chlamydia<\/i> from the Female Reproductive Tract"],"prefix":"10.1093","volume":"199","author":[{"given":"Lin-Xi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, AR 72205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine C","family":"Labuda","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California , Davis, Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-2054","authenticated-orcid":false,"given":"Denise M","family":"Imai","sequence":"additional","affiliation":[{"name":"Comparative Pathology Laboratory, School of Veterinary Medicine, University of California , Davis, Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Griffey","sequence":"additional","affiliation":[{"name":"Comparative Pathology Laboratory, School of Veterinary Medicine, University of California , Davis, Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"McSorley","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California , Davis, Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,1]]},"reference":[{"key":"2025030614470359600_r1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.immunol.19.1.23","article-title":"In vivo activation of antigen-specific CD4 T cells","volume":"19","author":"Jenkins","year":"2001","journal-title":"Annu. 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Immunol."},{"key":"2025030614470359600_r16","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1128\/iai.65.6.1993-1999.1997","article-title":"Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice","volume":"65","author":"Su","year":"1997","journal-title":"Infect. Immun."},{"key":"2025030614470359600_r17","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1128\/iai.65.8.3065-3073.1997","article-title":"Mouse strain-dependent variation in the course and outcome of chlamydial genital tract infection is associated with differences in host response","volume":"65","author":"Darville","year":"1997","journal-title":"Infect. 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Immunol."},{"key":"2025030614470359600_r23","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1002\/eji.201242614","article-title":"Multifaceted activities of CCR7 regulate T-cell homeostasis in health and disease","volume":"42","author":"Moschovakis","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"2025030614470359600_r24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/B978-0-12-417028-5.00002-8","article-title":"Dendritic cell migration through the lymphatic vasculature to lymph nodes","volume":"120","author":"Platt","year":"2013","journal-title":"Adv. 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Microbiol."},{"key":"2025030614470359600_r34","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1128\/iai.63.12.4704-4714.1995","article-title":"Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection","volume":"63","author":"Cotter","year":"1995","journal-title":"Infect. Immun."},{"key":"2025030614470359600_r35","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nprot.2009.9","article-title":"Tracking epitope-specific T cells","volume":"4","author":"Moon","year":"2009","journal-title":"Nat. Protoc."},{"key":"2025030614470359600_r36","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/ni.2568","article-title":"Sensing and alarm function of resident memory CD8+ T cells","volume":"14","author":"Schenkel","year":"2013","journal-title":"Nat. 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Med."},{"key":"2025030614470359600_r46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1257530","article-title":"T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells","volume":"346","author":"Iijima","year":"2014","journal-title":"Science"},{"key":"2025030614470359600_r47","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/ni1240","article-title":"Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics","volume":"6","author":"Bromley","year":"2005","journal-title":"Nat. Immunol."},{"key":"2025030614470359600_r48","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1128\/IAI.00881-10","article-title":"Vaccination against Chlamydia genital infection utilizing the murine C. muridarum model","volume":"79","author":"Farris","year":"2011","journal-title":"Infect. 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Immun."},{"key":"2025030614470359600_r51","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1128\/iai.63.12.4661-4668.1995","article-title":"Gene knockout mice establish a primary protective role for major histocompatibility complex class II\u2013restricted responses in Chlamydia trachomatis genital tract infection","volume":"63","author":"Morrison","year":"1995","journal-title":"Infect. Immun."},{"key":"2025030614470359600_r52","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1128\/IAI.69.4.2643-2649.2001","article-title":"Resolution of secondary Chlamydia trachomatis genital tract infection in immune mice with depletion of both CD4+ and CD8+ T cells","volume":"69","author":"Morrison","year":"2001","journal-title":"Infect. 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