{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:42:21Z","timestamp":1790228541497,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Toll-like receptors play a central role in the initiation of adaptive immune responses with several TLR agonists acting as known B cell mitogens. Despite thousands of publications on TLRs, the function of TLR10 remains unknown. We have found that Ab-mediated engagement of TLR10 on primary human B cells suppresses B cell proliferation, cytokine production, and signal transduction. When challenged with either a T independent or T dependent Ag, TLR10 transgenic mice exhibit diminished Ab responses. Adoptive transfer of splenic B cells into B cell\u2013deficient mice revealed that the suppressive effects on Ag-specific humoral immune responses are entirely B cell intrinsic. Our results demonstrate that TLR10 has a functional role within the B cell lineage that is distinct from that of other TLR family members and may provide a potential therapeutic target for diseases characterized by dysregulated B cell activity.<\/jats:p>","DOI":"10.4049\/jimmunol.1601335","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T21:30:42Z","timestamp":1481578242000},"page":"699-707","source":"Crossref","is-referenced-by-count":44,"title":["TLR10 Is a B Cell Intrinsic Suppressor of Adaptive Immune Responses"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-9305","authenticated-orcid":false,"given":"Nicholas J","family":"Hess","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Illinois at Urbana-Champaign , Urbana, IL 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-4327","authenticated-orcid":false,"given":"Song","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Illinois at Urbana-Champaign , Urbana, IL 61801"},{"name":"College of Medicine, University of Illinois at Urbana-Champaign , Urbana, IL 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Illinois at Urbana-Champaign , Urbana, IL 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Illinois at Urbana-Champaign , Urbana, IL 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I","family":"Tapping","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Illinois at Urbana-Champaign , Urbana, IL 61801"},{"name":"College of Medicine, University of Illinois at Urbana-Champaign , Urbana, IL 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,15]]},"reference":[{"key":"2025030614595565000_r1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. 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