{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:20:19Z","timestamp":1790774419813,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human respiratory syncytial virus (hRSV) is the leading cause of severe lower respiratory tract infections in children. The development of novel prophylactic and therapeutic antiviral drugs against hRSV is imperative to control the burden of disease in the susceptible population. In this study, we examined the effects of inducing the activity of the host enzyme heme oxygenase-1 (HO-1) on hRSV replication and pathogenesis on lung inflammation induced by this virus. Our results show that after hRSV infection, HO-1 induction with metalloporphyrin cobalt protoporphyrin IX significantly reduces the loss of body weight due to hRSV-induced disease. Further, HO-1 induction also decreased viral replication and lung inflammation, as evidenced by a reduced neutrophil infiltration into the airways, with diminished cytokine and chemokine production and reduced T cell function. Concomitantly, upon cobalt protoporphyrin IX treatment, there is a significant upregulation in the production of IFN-\u03b1\/\u03b2 mRNAs in the lungs. Furthermore, similar antiviral and protective effects occur by inducing the expression of human HO-1 in MHC class II+ cells in transgenic mice. Finally, in vitro data suggest that HO-1 induction can modulate the susceptibility of cells, especially the airway epithelial cells, to hRSV infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1601414","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:50:17Z","timestamp":1496278217000},"page":"212-223","source":"Crossref","is-referenced-by-count":61,"title":["Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection"],"prefix":"10.1093","volume":"199","author":[{"given":"Janyra A","family":"Espinoza","sequence":"first","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7647-5454","authenticated-orcid":false,"given":"Miguel A","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo F","family":"C\u00e9spedes","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto S","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Canedo-Marroqu\u00edn","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebast\u00edan A","family":"Riquelme","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6709-699X","authenticated-orcid":false,"given":"Francisco J","family":"Salazar-Echegarai","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillipe","family":"Blancou","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universit\u00e9 de Nantes , Nantes 44093,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Simon","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universit\u00e9 de Nantes , Nantes 44093,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Anegon","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universit\u00e9 de Nantes , Nantes 44093,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-7977","authenticated-orcid":false,"given":"Margarita K","family":"Lay","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, Facultad de Ciencias del Mar y Recursos Biol\u00f3gicos, Universidad de Antofagasta , Antofagasta 1270300,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7709-6870","authenticated-orcid":false,"given":"Pablo A","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia A","family":"Riedel","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Biol\u00f3gicas y Facultad de Medicina, Universidad Andr\u00e9s Bello , Santiago 8370134,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Bueno","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis M","family":"Kalergis","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia, Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]},{"name":"Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universit\u00e9 de Nantes , Nantes 44093,","place":["France"]},{"name":"Departamento de Endocrinolog\u00eda, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile , Santiago 8331150,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,7,1]]},"reference":[{"issue":"Suppl. 2","key":"2025030612121815300_r1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/14767058.2013.831282","article-title":"New perspectives in respiratory syncitial virus infection","volume":"26","author":"Del Vecchio","year":"2013","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"2025030612121815300_r2","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/S2213-2600(15)00255-6","article-title":"Lower respiratory tract infection caused by respiratory syncytial virus: current management and new therapeutics","volume":"3","author":"Mazur","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"2025030612121815300_r3","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(10)60206-1","article-title":"Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis","volume":"375","author":"Nair","year":"2010","journal-title":"Lancet"},{"key":"2025030612121815300_r4","doi-asserted-by":"crossref","first-page":"9112","DOI":"10.1073\/pnas.1217508110","article-title":"Impaired learning resulting from respiratory syncytial virus infection","volume":"110","author":"Espinoza","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030612121815300_r5","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.braindev.2006.11.007","article-title":"Cerebral involvement in respiratory syncytial virus disease","volume":"29","author":"Eisenhut","year":"2007","journal-title":"Brain Dev."},{"key":"2025030612121815300_r6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.vaccine.2016.12.048","article-title":"A single, low dose of a cGMP recombinant BCG vaccine elicits protective T cell immunity against the human respiratory syncytial virus infection and prevents lung pathology in mice","volume":"35","author":"C\u00e9spedes","year":"2017","journal-title":"Vaccine"},{"key":"2025030612121815300_r7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s41061-017-0129-4","article-title":"Recent advances in developing antiviral therapies for respiratory syncytial virus","volume":"375","author":"Shook","year":"2017","journal-title":"Top Curr Chem (J)"},{"key":"2025030612121815300_r8","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3390\/ijms18030556","article-title":"Immunological features of respiratory syncytial virus-caused pneumonia-implications for vaccine design","volume":"18","author":"Rey-Jurado","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"2025030612121815300_r9","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.bbrc.2005.08.020","article-title":"Heme oxygenase and heme degradation","volume":"338","author":"Kikuchi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025030612121815300_r10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ajpath.2016.11.011","article-title":"Modulation of antiviral immunity by heme oxygenase-1","volume":"187","author":"Espinoza","year":"2017","journal-title":"Am. J. Pathol."},{"key":"2025030612121815300_r11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/mi.2015.39","article-title":"Tissue heme oxygenase-1 exerts anti-inflammatory effects on LPS-induced pulmonary inflammation","volume":"9","author":"Konrad","year":"2016","journal-title":"Mucosal Immunol."},{"key":"2025030612121815300_r12","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1182\/blood-2005-02-0494","article-title":"Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression","volume":"106","author":"Chauveau","year":"2005","journal-title":"Blood"},{"key":"2025030612121815300_r13","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.4049\/jimmunol.172.8.4744","article-title":"Carbon monoxide produced by heme oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production","volume":"172","author":"Pae","year":"2004","journal-title":"J. Immunol."},{"key":"2025030612121815300_r14","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1084\/jem.20081582","article-title":"Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production","volume":"206","author":"Tzima","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025030612121815300_r15","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1096\/fj.06-6346fje","article-title":"Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin","volume":"20","author":"Shan","year":"2006","journal-title":"FASEB J."},{"key":"2025030612121815300_r16","first-page":"487","article-title":"Modulation of antiviral immunity by heme oxygenase-1","volume-title":"Am. J. Pathol.","author":"Espinoza"},{"key":"2025030612121815300_r17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/10623320500189814","article-title":"Expression of heme oxygenase-1 protects endothelial cells from irradiation-induced apoptosis","volume":"12","author":"Ewing","year":"2005","journal-title":"Endothelium"},{"key":"2025030612121815300_r18","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1073\/pnas.84.8.2464","article-title":"Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver","volume":"84","author":"Sardana","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030612121815300_r19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1084\/jem.191.2.355","article-title":"Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules","volume":"191","author":"Witherden","year":"2000","journal-title":"J. Exp. Med."},{"key":"2025030612121815300_r20","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"Inaba","year":"1992","journal-title":"J. Exp. Med."},{"key":"2025030612121815300_r21","doi-asserted-by":"crossref","first-page":"20822","DOI":"10.1073\/pnas.0806244105","article-title":"Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG","volume":"105","author":"Bueno","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030612121815300_r22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/imm.12375","article-title":"Carbon monoxide down-modulates Toll-like receptor 4\/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility","volume":"144","author":"Riquelme","year":"2015","journal-title":"Immunology"},{"key":"2025030612121815300_r23","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1086\/386372","article-title":"Respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in mice","volume":"189","author":"Jafri","year":"2004","journal-title":"J. Infect. Dis."},{"key":"2025030612121815300_r24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/cei.12451","article-title":"Modulation of heme oxygenase-1 by metalloporphyrins increases anti-viral T cell responses","volume":"179","author":"Bunse","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"2025030612121815300_r25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nchembio.1982","article-title":"Molecular mechanism of respiratory syncytial virus fusion inhibitors","volume":"12","author":"Battles","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"2025030612121815300_r26","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.4049\/jimmunol.1502478","article-title":"Cathelicidins have direct antiviral activity against respiratory syncytial virus in vitro and protective function in vivo in mice and humans","volume":"196","author":"Currie","year":"2016","journal-title":"J. Immunol."},{"key":"2025030612121815300_r27","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1128\/jvi.65.8.4063-4069.1991","article-title":"Characteristics of fusion of respiratory syncytial virus with HEp-2 cells as measured by R18 fluorescence dequenching assay","volume":"65","author":"Srinivasakumar","year":"1991","journal-title":"J. Virol."},{"key":"2025030612121815300_r28","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1002\/eji.201343600","article-title":"Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells","volume":"43","author":"Tardif","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"2025030612121815300_r29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/imm.12124","article-title":"Carbon monoxide exposure improves immune function in lupus-prone mice","volume":"140","author":"Mackern-Oberti","year":"2013","journal-title":"Immunology"},{"issue":"4 Suppl.","key":"2025030612121815300_r30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2217\/imt.11.43","article-title":"Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer","volume":"3","author":"Simon","year":"2011","journal-title":"Immunotherapy"},{"key":"2025030612121815300_r31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1165\/ajrcmb.15.1.8679227","article-title":"Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury","volume":"15","author":"Choi","year":"1996","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025030612121815300_r32","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI28844","article-title":"Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation","volume":"117","author":"Chora","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2025030612121815300_r33","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.4049\/jimmunol.177.4.2592","article-title":"Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes","volume":"177","author":"Drechsler","year":"2006","journal-title":"J. Immunol."},{"key":"2025030612121815300_r34","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/hep.23339","article-title":"The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response","volume":"51","author":"Lehmann","year":"2010","journal-title":"Hepatology"},{"key":"2025030612121815300_r35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12605","article-title":"Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance","volume":"149","author":"Riquelme","year":"2016","journal-title":"Immunology"},{"key":"2025030612121815300_r36","doi-asserted-by":"crossref","first-page":"7633","DOI":"10.4049\/jimmunol.0903452","article-title":"Efficient lung recruitment of respiratory syncytial virus-specific Th1 cells induced by recombinant bacillus Calmette-Gu\u00e9rin promotes virus clearance and protects from infection","volume":"185","author":"Cautivo","year":"2010","journal-title":"J. Immunol."},{"key":"2025030612121815300_r37","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1089\/ars.2013.5674","article-title":"Signaling function of heme oxygenase proteins","volume":"20","author":"Dennery","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"2025030612121815300_r38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1124\/pr.107.07104","article-title":"Pharmacological and clinical aspects of heme oxygenase","volume":"60","author":"Abraham","year":"2008","journal-title":"Pharmacol. Rev."},{"key":"2025030612121815300_r39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1023\/A:1015957026924","article-title":"Heme oxygenase\/carbon monoxide signaling pathways: regulation and functional significance","volume":"234\u2013235","author":"Ryter","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"2025030612121815300_r40","doi-asserted-by":"crossref","first-page":"859235","DOI":"10.1155\/2012\/859235","article-title":"Therapeutic potential of heme oxygenase-1\/carbon monoxide in lung disease","volume":"2012","author":"Constantin","year":"2012","journal-title":"Int. J. Hypertens."},{"key":"2025030612121815300_r41","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/978-1-60761-869-0_18","article-title":"Immunoregulatory properties of heme oxygenase-1","volume":"677","author":"Blancou","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"2025030612121815300_r42","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2174\/1566523214666140424150308","article-title":"Heme oxygenase-1 as a target for the design of gene and pharmaceutical therapies for autoimmune diseases","volume":"14","author":"Mackern-Oberti","year":"2014","journal-title":"Curr. Gene Ther."},{"key":"2025030612121815300_r43","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1172\/JCI32730","article-title":"Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice","volume":"118","author":"Chung","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2025030612121815300_r44","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1462-5822.2008.01261.x","article-title":"Role of haem oxygenase-1 in microbial host defence","volume":"11","author":"Chung","year":"2009","journal-title":"Cell. Microbiol."},{"key":"2025030612121815300_r45","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/sj.gt.3301540","article-title":"Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice","volume":"8","author":"Hashiba","year":"2001","journal-title":"Gene Ther."},{"key":"2025030612121815300_r46","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.freeradbiomed.2016.04.021","article-title":"Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response","volume":"96","author":"Ma","year":"2016","journal-title":"Free Radic Biol Med."},{"key":"2025030612121815300_r47","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1096\/fj.11-190017","article-title":"Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice","volume":"26","author":"Cummins","year":"2012","journal-title":"FASEB J."},{"key":"2025030612121815300_r48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11262-006-0064-x","article-title":"Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1\/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy--a review","volume":"33","author":"Becker","year":"2006","journal-title":"Virus Genes"},{"key":"2025030612121815300_r49","doi-asserted-by":"crossref","first-page":"8948","DOI":"10.1128\/JVI.79.14.8948-8959.2005","article-title":"Respiratory syncytial virus influences NF-kappaB-dependent gene expression through a novel pathway involving MAP3K14\/NIK expression and nuclear complex formation with NF-kappaB2","volume":"79","author":"Choudhary","year":"2005","journal-title":"J. Virol."},{"key":"2025030612121815300_r50","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1007\/s10753-012-9452-7","article-title":"Resveratrol Inhibits respiratory syncytial virus-induced IL-6 production, decreases viral replication, and downregulates TRIF expression in airway epithelial cells","volume":"35","author":"Xie","year":"2012","journal-title":"Inflammation"},{"key":"2025030612121815300_r51","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3181\/0810-RM-312","article-title":"Heme oxygenase-1 inhibits pro-oxidant induced hypertrophy in HL-1 cardiomyocytes","volume":"234","author":"Brunt","year":"2009","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"2025030612121815300_r52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nm0196-87","article-title":"Heme oxygenase: a novel target for the modulation of the inflammatory response","volume":"2","author":"Willis","year":"1996","journal-title":"Nat. Med."},{"key":"2025030612121815300_r53","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1164\/rccm.200804-535OC","article-title":"Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease","volume":"179","author":"Cho","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025030612121815300_r54","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nri3754","article-title":"Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?","volume":"14","author":"Kambayashi","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2025030612121815300_r55","doi-asserted-by":"crossref","first-page":"14999","DOI":"10.1073\/pnas.0802555105","article-title":"Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells","volume":"105","author":"Gonz\u00e1lez","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030612121815300_r56","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/clpt.2009.221","article-title":"First-in-human study demonstrating pharmacological activation of heme oxygenase-1 in humans","volume":"87","author":"Bharucha","year":"2010","journal-title":"Clin. Pharmacol. Ther."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/199\/1\/212\/61512662\/ji1601414.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/199\/1\/212\/61512662\/ji1601414.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T13:23:50Z","timestamp":1741267430000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/199\/1\/212\/7962236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1601414","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,7,1]]}}}