{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:10:25Z","timestamp":1790050225107,"version":"4.0.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Allergic asthma develops in the mucosal tissue of small bronchi. At these sites, local cytokine production by Th2\/Th17 cells is believed to be critical for the development of tissue eosinophilia\/neutrophilia. Using the mouse trachea as a relevant model of human small airways, we performed advanced in vivo dynamic and in situ static imaging to visualize individual cytokine-producing T cells in the airway mucosa and to define their immediate cellular environment. Upon allergen sensitization, newly recruited CD4+ T cells formed discrete Ag-driven clusters with dendritic cells (DCs). Within T cell\u2013DC clusters, a small fraction of CD4+ T cells produced IL-13 or IL-17 following prolonged Ag-specific interactions with DCs. As a result of local Th2 cytokine signaling, eosinophils were recruited into these clusters. Neutrophils also infiltrated these clusters in a T cell\u2013dependent manner, but their mucosal distribution was more diffuse. Our findings reveal the focal nature of allergen-driven responses in the airways and define multiple steps with potential for interference with the progression of asthmatic pathology.<\/jats:p>","DOI":"10.4049\/jimmunol.1601448","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T03:00:20Z","timestamp":1480561220000},"page":"895-907","source":"Crossref","is-referenced-by-count":23,"title":["Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell\u2013T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6980-8900","authenticated-orcid":false,"given":"Tibor Z","family":"Veres","sequence":"first","affiliation":[{"name":"MediCity Research Laboratory, University of Turku , 20520 Turku,","place":["Finland"]},{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Kopcs\u00e1nyi","sequence":"additional","affiliation":[{"name":"MediCity Research Laboratory, University of Turku , 20520 Turku,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"van Panhuys","sequence":"additional","affiliation":[{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"},{"name":"Sidra Medical and Research Center , Doha,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y","family":"Gerner","sequence":"additional","affiliation":[{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiduo","family":"Liu","sequence":"additional","affiliation":[{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-5075","authenticated-orcid":false,"given":"Pia","family":"Rantakari","sequence":"additional","affiliation":[{"name":"MediCity Research Laboratory, University of Turku , 20520 Turku,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Dunkel","sequence":"additional","affiliation":[{"name":"MediCity Research Laboratory, University of Turku , 20520 Turku,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6122-5201","authenticated-orcid":false,"given":"Masayuki","family":"Miyasaka","sequence":"additional","affiliation":[{"name":"MediCity Research Laboratory, University of Turku , 20520 Turku,","place":["Finland"]},{"name":"World Premier International Immunology Frontier Research Center, Osaka University , Osaka 565-0871,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Salmi","sequence":"additional","affiliation":[{"name":"MediCity Research Laboratory, University of Turku , 20520 Turku,","place":["Finland"]},{"name":"Department of Medical Microbiology and Immunology, University of Turku , 20520 Turku,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirpa","family":"Jalkanen","sequence":"additional","affiliation":[{"name":"MediCity Research Laboratory, University of Turku , 20520 Turku,","place":["Finland"]},{"name":"Department of Medical Microbiology and Immunology, University of Turku , 20520 Turku,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald N","family":"Germain","sequence":"additional","affiliation":[{"name":"Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,15]]},"reference":[{"key":"2025030614590339500_r1","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nri2870","article-title":"Functions of T cells in asthma: more than just T(H)2 cells","volume":"10","author":"Lloyd","year":"2010","journal-title":"Nat. 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