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IL-12p35, IL-23p19, and IL-12\/IL-23p40 knockout mice on a C3H\/HeN background, subjected to a melanomagenesis protocol, demonstrated profound differences in susceptibility to nevus initiation, transformation, tumorigenicity, and metastatic potential. IL-23 was found to be essential for melanocyte homeostasis, whereas IL-12 supported nevus development. A direct action of IL-23 on primary melanocytes, shown to be IL-23R+, demonstrated that DNA repair of damaged melanocytes requires IL-23. Furthermore, IL-23 modulated the cutaneous microenvironment by limiting regulatory T cells and IFN-\u03b3 and inhibiting IL-10 production. Neutralizing Ab to IFN-\u03b3, but not IL-17, inhibited nevus development (p &amp;lt; 0.01).<\/jats:p>","DOI":"10.4049\/jimmunol.1601455","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T02:11:32Z","timestamp":1482372692000},"page":"950-961","source":"Crossref","is-referenced-by-count":18,"title":["IL-23 Inhibits Melanoma Development by Augmenting DNA Repair and Modulating T Cell Subpopulations"],"prefix":"10.1093","volume":"198","author":[{"given":"Tahseen H","family":"Nasti","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Alabama at Birmingham School of Medicine , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Barry","family":"Cochran","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Alabama at Birmingham School of Medicine , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3387-943X","authenticated-orcid":false,"given":"Raj V","family":"Vachhani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Alabama at Birmingham School of Medicine , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristopher","family":"McKay","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Alabama at Birmingham School of Medicine , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Alabama at Birmingham School of Medicine , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Athar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Alabama at Birmingham School of Medicine , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8886-8354","authenticated-orcid":false,"given":"Laura","family":"Timares","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Alabama at Birmingham School of Medicine , Birmingham, AL 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig A","family":"Elmets","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Alabama at Birmingham School of Medicine , Birmingham, AL 35294"},{"name":"Birmingham Veterans Administration Medical Center , Birmingham, AL 35233"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,1,15]]},"reference":[{"key":"2025030614583974500_r1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3322\/caac.21208","article-title":"Cancer statistics, 2014","volume":"64","author":"Siegel","year":"2014","journal-title":"CA Cancer J. 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