{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:53:35Z","timestamp":1789073615596,"version":"build-2803163510"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IgG4-related disease (IgG4-RD) is a newly recognized systemic chronic fibroinflammatory disease. However, the pathogenesis of IgG4-RD remains unknown. To determine the pathophysiologic features of IgG4-RD, we examined T follicular helper (Tfh) cells in lesions and blood from patients with IgG4-RD. Patients with IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) showed increased infiltration of Tfh cells highly expressing programmed death 1 and ICOS in submandibular glands. Tfh cells from IgG4-DS submandibular glands had higher expression of B cell lymphoma 6 and a greater capacity to help B cells produce IgG4 than did tonsillar Tfh cells. We also found that the percentage of programmed death 1hi circulating Tfh cells in IgG4-DS patients was higher than that in healthy volunteers and was well correlated with clinical parameters. Our findings indicate that anomalous Tfh cells in tissue lesions of IgG4-RD have features distinct from those in lymphoid counterparts or blood and potentially regulate local IgG4 production in IgG4-RD.<\/jats:p>","DOI":"10.4049\/jimmunol.1601507","type":"journal-article","created":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T01:00:25Z","timestamp":1505523625000},"page":"2624-2629","source":"Crossref","is-referenced-by-count":70,"title":["Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease"],"prefix":"10.1093","volume":"199","author":[{"given":"Ryuta","family":"Kamekura","sequence":"first","affiliation":[{"name":"Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine , Chuo-ku, Sapporo 060-8556,","place":["Japan"]},{"name":"Department of Otolaryngology, Sapporo Medical University School of Medicine , Chuo-ku, Sapporo 060-8543,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-6384","authenticated-orcid":false,"given":"Kenichi","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Sapporo Medical University School of Medicine , Chuo-ku, Sapporo 060-8543,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2006-1751","authenticated-orcid":false,"given":"Motohisa","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sapporo Medical University School of Medicine , Chuo-ku, Sapporo 060-8543,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kawata","sequence":"additional","affiliation":[{"name":"Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine , Chuo-ku, Sapporo 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