{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:19:52Z","timestamp":1792667992311,"version":"4.5.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The coordinated recognition of virus-derived T cell epitopes and MHC molecules by T cells plays a pivotal role in cellular immunity\u2013mediated virus clearance. It has been demonstrated that the conformation of MHC class I (MHC I) molecules can be adjusted by the presented peptide, which impacts T cell activation. However, it is still largely unknown whether the conformational shift of MHC I influences the protective effect of virus-specific T cells. In this study, utilizing the Middle East respiratory syndrome coronavirus\u2013infected mouse model, we observed that through the unusual secondary anchor Ile5, a CD8+ T cell epitope drove the conformational fit of Trp73 on the \u03b11 helix of murine MHC I H-2Kd. In vitro renaturation and circular dichroism assays indicated that this shift of the structure did not influence the peptide\/MHC I binding affinity. Nevertheless, the T cell recognition and the protective effect of the peptide diminished when we made an Ile to Ala mutation at position 5 of the original peptide. The molecular bases of the concordant recognition of T cell epitopes and host MHC-dependent protection were demonstrated through both crystal structure determination and tetramer staining using the peptide\u2013MHC complex. Our results indicate a coordinated MHC I\/peptide interaction mechanism and provide a beneficial reference for T cell\u2013oriented vaccine development against emerging viruses such as Middle East respiratory syndrome coronavirus.<\/jats:p>","DOI":"10.4049\/jimmunol.1601542","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T03:00:20Z","timestamp":1480561220000},"page":"873-882","source":"Crossref","is-referenced-by-count":43,"title":["Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus\u2013Derived CD8+ T Cell Epitopes and Host MHC"],"prefix":"10.1093","volume":"198","author":[{"given":"William J","family":"Liu","sequence":"first","affiliation":[{"name":"College of Laboratory Medicine and Life Sciences, Institute of Medical Virology, Wenzhou Medical University , Wenzhou 325035,","place":["China"]},{"name":"Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral 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