{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:38:49Z","timestamp":1790199529997,"version":"4.1.0"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Group 3 innate lymphoid cells (ILC3s) are important regulators of the immune system, maintaining homeostasis in the presence of commensal bacteria, but activating immune defenses in response to microbial pathogens. ILC3s are a robust source of IL-22, a cytokine critical for stimulating the antimicrobial response. We sought to identify cytokines that can promote proliferation and induce or maintain IL-22 production by ILC3s and determine a molecular mechanism for this process. We identified IL-18 as a cytokine that cooperates with an ILC3 survival factor, IL-15, to induce proliferation of human ILC3s, as well as induce and maintain IL-22 production. To determine a mechanism of action, we examined the NF-\u03baB pathway, which is activated by IL-18 signaling. We found that the NF-\u03baB complex signaling component, p65, binds to the proximal region of the IL22 promoter and promotes transcriptional activity. Finally, we observed that CD11c+ dendritic cells expressing IL-18 are found in close proximity to ILC3s in human tonsils in situ. Therefore, we identify a new mechanism by which human ILC3s proliferate and produce IL-22, and identify NF-\u03baB as a potential therapeutic target to be considered in pathologic states characterized by overproduction of IL-18 and\/or IL-22.<\/jats:p>","DOI":"10.4049\/jimmunol.1601554","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T20:25:48Z","timestamp":1503692748000},"page":"2333-2342","source":"Crossref","is-referenced-by-count":106,"title":["IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-\u03baB"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-3088","authenticated-orcid":false,"given":"Aaron R","family":"Victor","sequence":"first","affiliation":[{"name":"Medical Scientist Training Program, Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansel P","family":"Nalin","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program, Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Dong","sequence":"additional","affiliation":[{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"McClory","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program, Ohio State University , Columbus, OH 43210"},{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wei","sequence":"additional","affiliation":[{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5517-7183","authenticated-orcid":false,"given":"Charlene","family":"Mao","sequence":"additional","affiliation":[{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raleigh D","family":"Kladney","sequence":"additional","affiliation":[{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 43210"},{"name":"Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University , Columbus, OH 43210"},{"name":"Department of Molecular Genetics, College of Biological Sciences, The Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-1521","authenticated-orcid":false,"given":"Wing Keung","family":"Chan","sequence":"additional","affiliation":[{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L","family":"Briercheck","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program, Ohio State University , Columbus, OH 43210"},{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 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43210"},{"name":"Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-9113","authenticated-orcid":false,"given":"Charlie","family":"Chen","sequence":"additional","affiliation":[{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0489-9645","authenticated-orcid":false,"given":"Sarah","family":"Manz","sequence":"additional","affiliation":[{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1348-269X","authenticated-orcid":false,"given":"Lai-Chu","family":"Wu","sequence":"additional","affiliation":[{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, Department of Bioinformatics, The Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"The James Cancer Hospital and Solove Research Institute, The Ohio State University Comprehensive Cancer Center , Columbus, OH 43210"},{"name":"Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University , Columbus, OH 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