{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:06:26Z","timestamp":1792062386207,"version":"4.4.0"},"reference-count":96,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Preterm birth (PTB) is commonly accompanied by in utero fetal inflammation, and existing tocolytic drugs do not target fetal inflammatory injury. Of the candidate proinflammatory mediators, IL-1 appears central and is sufficient to trigger fetal loss. Therefore, we elucidated the effects of antenatal IL-1 exposure on postnatal development and investigated two IL-1 receptor antagonists, the competitive inhibitor anakinra (Kineret) and a potent noncompetitive inhibitor 101.10, for efficacy in blocking IL-1 actions. Antenatal exposure to IL-1\u03b2 induced Tnfa, Il6, Ccl2, Pghs2, and Mpges1 expression in placenta and fetal membranes, and it elevated amniotic fluid IL-1\u03b2, IL-6, IL-8, and PGF2\u03b1, resulting in PTB and marked neonatal mortality. Surviving neonates had increased Il1b, Il6, Il8, Il10, Pghs2, Tnfa, and Crp expression in WBCs, elevated plasma levels of IL-1\u03b2, IL-6, and IL-8, increased IL-1\u03b2, IL-6, and IL-8 in fetal lung, intestine, and brain, and morphological abnormalities: e.g., disrupted lung alveolarization, atrophy of intestinal villus and colon-resident lymphoid follicle, and degeneration and atrophy of brain microvasculature with visual evoked potential anomalies. Late gestation treatment with 101.10 abolished these adverse outcomes, whereas Kineret exerted only modest effects and no benefit for gestation length, neonatal mortality, or placental inflammation. In a LPS-induced model of infection-associated PTB, 101.10 prevented PTB, neonatal mortality, and fetal brain inflammation. There was no substantive deviation in postnatal growth trajectory or adult body morphometry after antenatal 101.10 treatment. The results implicate IL-1 as an important driver of neonatal morbidity in PTB and identify 101.10 as a safe and effective candidate therapeutic.<\/jats:p>","DOI":"10.4049\/jimmunol.1601600","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T20:50:18Z","timestamp":1485982218000},"page":"2047-2062","source":"Crossref","is-referenced-by-count":117,"title":["Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice"],"prefix":"10.1093","volume":"198","author":[{"given":"Mathieu","family":"Nadeau-Vall\u00e9e","sequence":"first","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, University of Montreal , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0923-0553","authenticated-orcid":false,"given":"Peck-Yin","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Adelaide Medical School and Robinson Research Institute, University of Adelaide , Adelaide, South Australia 5005,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Belarbi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-\u00c8ve","family":"Brien","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Montreal, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1J4,","place":["Canada"]},{"name":"Department of Microbiology, Infectiology, and Immunology, University of Montreal, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Pundir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology and Therapeutics, McGill University , Montreal, Quebec H3G 1Y6,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H","family":"Berryer","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, CHU Sainte-Justine Research Center, University of Montreal , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5974-8916","authenticated-orcid":false,"given":"Alexandra","family":"Beaudry-Richard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankush","family":"Madaan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology and Therapeutics, McGill University , Montreal, Quebec H3G 1Y6,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-7950","authenticated-orcid":false,"given":"David J","family":"Sharkey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Adelaide Medical School and Robinson Research Institute, University of Adelaide , Adelaide, South Australia 5005,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2735-3554","authenticated-orcid":false,"given":"Alexis","family":"Lupien-Meilleur","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, CHU Sainte-Justine Research Center, University of Montreal , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Quiniou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Beaulac","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Boufaied","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Montreal, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1J4,","place":["Canada"]},{"name":"Department of Microbiology, Infectiology, and Immunology, University of Montreal, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarilys","family":"Boudreault","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Carbonaro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Montreal, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1J4,","place":["Canada"]},{"name":"Department of Microbiology, Infectiology, and Immunology, University of Montreal, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc-Duc","family":"Doan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Montreal , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3877-9614","authenticated-orcid":false,"given":"Jean-Sebastien","family":"Joyal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, University of Montreal , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3080-2712","authenticated-orcid":false,"given":"William D","family":"Lubell","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Montreal , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Alberta , Edmonton, Alberta T6G 2R3,","place":["Canada"]},{"name":"Department of Pediatrics, University of Alberta , Edmonton, Alberta T6G 2R3,","place":["Canada"]},{"name":"Department of Physiology, University of Alberta , Edmonton, Alberta T6G 2R3,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Adelaide Medical School and Robinson Research Institute, University of Adelaide , Adelaide, South Australia 5005,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Girard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Montreal, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1J4,","place":["Canada"]},{"name":"Department of Microbiology, Infectiology, and Immunology, University of Montreal, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Chemtob","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5,","place":["Canada"]},{"name":"Department of Pharmacology, University of Montreal , Montreal, Quebec H3T 1J4,","place":["Canada"]},{"name":"Department of Pharmacology and Therapeutics, McGill University , Montreal, Quebec H3G 1Y6,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"2025031312201629300_r1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1742-4755-10-S1-S2","article-title":"Born too soon: the global epidemiology of 15 million preterm births","volume":"10","author":"Blencowe","year":"2013","journal-title":"Reprod. Health"},{"key":"2025031312201629300_r2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/aji.12296","article-title":"Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes","volume":"72","author":"Romero","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025031312201629300_r3","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/GRF.0b013e31811ebef6","article-title":"The fetal inflammatory response syndrome","volume":"50","author":"Gotsch","year":"2007","journal-title":"Clin. Obstet. Gynecol."},{"key":"2025031312201629300_r4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0002-9378(99)70299-1","article-title":"A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia","volume":"181","author":"Yoon","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r5","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1067\/mob.2000.104207","article-title":"Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years","volume":"182","author":"Yoon","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000067956","article-title":"Chorioamnionitis: a risk factor for fetal and neonatal morbidity","volume":"83","author":"Bracci","year":"2003","journal-title":"Biol. Neonate"},{"key":"2025031312201629300_r7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1515\/JPM.2005.003","article-title":"IL-8 concentrations in maternal serum, amniotic fluid and cord blood in relation to different pathogens within the amniotic cavity","volume":"33","author":"Witt","year":"2005","journal-title":"J. Perinat. Med."},{"key":"2025031312201629300_r8","doi-asserted-by":"crossref","first-page":"561494","DOI":"10.1155\/2012\/561494","article-title":"The role of cytokines and inflammatory cells in perinatal brain injury","volume":"2012","author":"McAdams","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"2025031312201629300_r9","first-page":"535","article-title":"Relationship between cytokine IL 6 levels and early-onset neonatal morbidity","volume":"30","author":"Hanzl","year":"2009","journal-title":"Neuroendocrinol. Lett."},{"key":"2025031312201629300_r10","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.3109\/14767058.2013.798284","article-title":"Acute lung injury in preterm fetuses and neonates: mechanisms and molecular pathways","volume":"26","author":"Iliodromiti","year":"2013","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"2025031312201629300_r11","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1097\/01.AOG.0000428649.57622.a7","article-title":"ACOG committee opinion no. 561: nonmedically indicated early-term deliveries","volume":"121","author":"American College of Obstetricians and Gynecologists","year":"2013","journal-title":"Obstet. Gynecol."},{"key":"2025031312201629300_r12","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.earlhumdev.2005.07.004","article-title":"Fetal and neonatal origins of altered brain development","volume":"81","author":"Rees","year":"2005","journal-title":"Early Hum. Dev."},{"key":"2025031312201629300_r13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2174\/187152309789152020","article-title":"Neonatal necrotizing enterocolitis -inflammation and intestinal immaturity","volume":"8","author":"Claud","year":"2009","journal-title":"Antiinflamm. Antiallergy Agents Med. Chem."},{"key":"2025031312201629300_r14","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.ajog.2005.05.072","article-title":"Inflammatory-mediated model of cerebral palsy with developmental sequelae","volume":"193","author":"Toso","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00383-013-3460-z","article-title":"The effect of vascular endothelial growth factor overexpression in experimental necrotizing enterocolitis","volume":"30","author":"Karatepe","year":"2014","journal-title":"Pediatr. Surg. Int."},{"key":"2025031312201629300_r16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.aanat.2013.02.010","article-title":"Bronchopulmonary dysplasia in a double-hit mouse model induced by intrauterine hypoxia and postnatal hyperoxia: closer to clinical features?","volume":"195","author":"Gortner","year":"2013","journal-title":"Ann. Anat."},{"key":"2025031312201629300_r17","doi-asserted-by":"crossref","first-page":"14384","DOI":"10.1073\/pnas.1306859110","article-title":"Interleukin-1 receptor antagonist prevents murine bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia","volume":"110","author":"Nold","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025031312201629300_r18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00383-013-3415-4","article-title":"Beneficial effects of Etanercept on experimental necrotizing enterocolitis","volume":"30","author":"Yurttutan","year":"2014","journal-title":"Pediatr. Surg. Int."},{"key":"2025031312201629300_r19","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.bbi.2012.09.001","article-title":"Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and\/or hypoxic-ischemic injuries","volume":"26","author":"Girard","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"2025031312201629300_r20","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: one syndrome, many causes","volume":"345","author":"Romero","year":"2014","journal-title":"Science"},{"key":"2025031312201629300_r21","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1542\/peds.103.4.766","article-title":"Circulating pro- and counterinflammatory cytokine levels and severity in necrotizing enterocolitis","volume":"103","author":"Edelson","year":"1999","journal-title":"Pediatrics"},{"key":"2025031312201629300_r22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000081504","article-title":"Interleukin-1 balance in the lungs of preterm infants who develop bronchopulmonary dysplasia","volume":"87","author":"Kakkera","year":"2005","journal-title":"Biol. Neonate"},{"key":"2025031312201629300_r23","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/jp.2015.86","article-title":"Elevated plasma and cerebrospinal fluid interleukin-1\u03b2 and tumor necrosis factor-alpha concentration and combined outcome of death or abnormal neuroimaging in preterm neonates with early-onset clinical sepsis","volume":"35","author":"Basu","year":"2015","journal-title":"J. Perinatol."},{"key":"2025031312201629300_r24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/jmf.14.3.205.211","article-title":"Interleukin-1\u03b2 in the bronchoalveolar lavage fluid of premature neonates: a marker for maternal chorioamnionitis and predictor of adverse neonatal outcome","volume":"14","author":"Cayabyab","year":"2003","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"2025031312201629300_r25","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neuroscience.2010.03.024","article-title":"Interleukin-1\u03b2-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by \u03b1-phenyl-n-tert-butyl-nitrone","volume":"168","author":"Fan","year":"2010","journal-title":"Neuroscience"},{"key":"2025031312201629300_r26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/labinvest.2015.127","article-title":"Selective IL-1\u03b1 exposure to the fetal gut, lung, and chorioamnion\/skin causes intestinal inflammatory and developmental changes in fetal sheep","volume":"96","author":"Nikiforou","year":"2016","journal-title":"Lab. Invest."},{"key":"2025031312201629300_r27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1165\/rcmb.2006-0116OC","article-title":"IL-1\u03b2 disrupts postnatal lung morphogenesis in the mouse","volume":"36","author":"Bry","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025031312201629300_r28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12974-015-0330-8","article-title":"Neuronal self-injury mediated by IL-1\u03b2 and MMP-9 in a cerebral palsy model of severe neonatal encephalopathy induced by immune activation plus hypoxia-ischemia","volume":"12","author":"Savard","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"2025031312201629300_r29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1742-2094-10-110","article-title":"Involvement of neuronal IL-1\u03b2 in acquired brain lesions in a rat model of neonatal encephalopathy","volume":"10","author":"Savard","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"2025031312201629300_r30","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1164\/rccm.200811-1728OC","article-title":"IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide","volume":"179","author":"Kallapur","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025031312201629300_r31","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1073\/pnas.94.5.2007","article-title":"Inhibition of interleukin 1\u03b2 converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage","volume":"94","author":"Hara","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025031312201629300_r32","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1016\/j.ajpath.2016.08.004","article-title":"Choroidal involution is associated with a progressive degeneration of the outer retinal function in a model of retinopathy of prematurity: early role for IL-1\u03b2","volume":"186","author":"Zhou","year":"2016","journal-title":"Am. J. Pathol."},{"key":"2025031312201629300_r33","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1161\/ATVBAHA.113.301331","article-title":"Microglia and interleukin-1\u03b2 in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A","volume":"33","author":"Rivera","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025031312201629300_r34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.brainres.2012.10.025","article-title":"Interleukin-1\u03b2 inhibits the differentiation of hippocampal neural precursor cells into serotonergic neurons","volume":"1490","author":"Zhang","year":"2013","journal-title":"Brain Res."},{"key":"2025031312201629300_r35","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijdevneu.2014.09.006","article-title":"IL-1\u03b2 increases necrotic neuronal cell death in the developing rat hippocampus after status epilepticus by activating type I IL-1 receptor (IL-1RI)","volume":"38","author":"Medel-Matus","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"2025031312201629300_r36","first-page":"77","article-title":"Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile","volume":"44","author":"Romero","year":"2016","journal-title":"J. Perinat. Med."},{"key":"2025031312201629300_r37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0002-9378(97)70432-0","article-title":"Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1\u03b2, and tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy","volume":"177","author":"Yoon","year":"1997","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0897.2012.01110.x","article-title":"Models of fetal brain injury, intrauterine inflammation, and preterm birth","volume":"67","author":"Burd","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025031312201629300_r39","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0002-9378(89)90172-5","article-title":"Infection and labor. III. Interleukin-1: a signal for the onset of parturition","volume":"160","author":"Romero","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r40","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0002-9378(91)90450-6","article-title":"Systemic administration of interleukin-1 induces preterm parturition in mice","volume":"165","author":"Romero","year":"1991","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r41","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.ajog.2006.06.072","article-title":"Preterm labor is induced by intraamniotic infusions of interleukin-1\u03b2 and tumor necrosis factor-\u03b1 but not by interleukin-6 or interleukin-8 in a nonhuman primate model","volume":"195","author":"Sadowsky","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r42","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.4049\/jimmunol.1500758","article-title":"Novel noncompetitive IL-1 receptor-biased ligand prevents infection- and inflammation-induced preterm birth","volume":"195","author":"Nadeau-Vall\u00e9e","year":"2015","journal-title":"J. Immunol."},{"key":"2025031312201629300_r43","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cytogfr.2015.11.001","article-title":"A critical role of interleukin-1 in preterm labor","volume":"28","author":"Nadeau-Vall\u00e9e","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025031312201629300_r44","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.4049\/jimmunol.180.10.6977","article-title":"Development of a novel noncompetitive antagonist of IL-1 receptor","volume":"180","author":"Quiniou","year":"2008","journal-title":"J. Immunol."},{"key":"2025031312201629300_r45","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/molehr\/6.6.561","article-title":"NF-\u03baB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH)","volume":"6","author":"Allport","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"2025031312201629300_r46","doi-asserted-by":"crossref","first-page":"504952","DOI":"10.1155\/2012\/504952","article-title":"NF\u03baB and AP-1 drive human myometrial IL8 expression","volume":"2012","author":"Khanjani","year":"2012","journal-title":"Mediators Inflamm."},{"key":"2025031312201629300_r47","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.biocel.2013.04.003","article-title":"Transcriptional regulation of increased CCL2 expression in pulmonary fibrosis involves nuclear factor-\u03baB and activator protein-1","volume":"45","author":"Deng","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2025031312201629300_r48","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1096\/fj.13-247783","article-title":"Activator protein 1 is a key terminal mediator of inflammation-induced preterm labor in mice","volume":"28","author":"MacIntyre","year":"2014","journal-title":"FASEB J."},{"key":"2025031312201629300_r49","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.1021\/ja9010628","article-title":"Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides","volume":"131","author":"Jamieson","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"2025031312201629300_r50","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/psc.1337","article-title":"Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin-1 receptor, by positional scanning using \u03b2-amino \u03b3-lactams","volume":"17","author":"Boutard","year":"2011","journal-title":"J. Pept. Sci."},{"key":"2025031312201629300_r51","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.freeradbiomed.2008.04.018","article-title":"Influence of lung oxidant and antioxidant status on alveolarization: role of light-exposed total parenteral nutrition","volume":"45","author":"Lavoie","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"2025031312201629300_r52","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1095\/biolreprod.116.140905","article-title":"Uterotonic neuromedin U receptor 2 and its ligands are upregulated by inflammation in mice and humans, and elicit preterm birth","volume":"95","author":"Nadeau-Vall\u00e9e","year":"2016","journal-title":"Biol. Reprod."},{"key":"2025031312201629300_r53","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1097\/NEN.0b013e3181f971e4","article-title":"Proinflammatory orientation of the interleukin 1 system and downstream induction of matrix metalloproteinase 9 in the pathophysiology of human perinatal white matter damage","volume":"69","author":"Girard","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"2025031312201629300_r54","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jsgi.2005.06.006","article-title":"Effect of stimulation and antagonism of interleukin-1 signaling on preterm delivery in mice","volume":"12","author":"Yoshimura","year":"2005","journal-title":"J. Soc. Gynecol. Investig."},{"key":"2025031312201629300_r55","doi-asserted-by":"crossref","first-page":"125.e1","DOI":"10.1016\/j.ajog.2013.11.032","article-title":"Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes","volume":"210","author":"Combs","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r56","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0002-9378(98)70272-8","article-title":"The fetal inflammatory response syndrome","volume":"179","author":"Gomez","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1742-2094-11-87","article-title":"Neonatal systemic inflammation in rats alters retinal vessel development and simulates pathologic features of retinopathy of prematurity","volume":"11","author":"Hong","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"2025031312201629300_r58","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1111\/j.1753-4887.2010.00352.x","article-title":"Vascular basis for brain degeneration: faltering controls and risk factors for dementia","volume":"68","author":"Kalaria","year":"2010","journal-title":"Nutr. Rev."},{"key":"2025031312201629300_r59","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.neuroscience.2008.10.032","article-title":"Developmental motor deficits induced by combined fetal exposure to lipopolysaccharide and early neonatal hypoxia\/ischemia: a novel animal model for cerebral palsy in very premature infants","volume":"158","author":"Girard","year":"2009","journal-title":"Neuroscience"},{"key":"2025031312201629300_r60","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1203\/01.PDR.0000117843.21534.49","article-title":"Caudate and hippocampal volumes, intelligence, and motor impairment in 7-year-old children who were born preterm","volume":"55","author":"Abernethy","year":"2004","journal-title":"Pediatr. Res."},{"key":"2025031312201629300_r61","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.clinph.2004.09.025","article-title":"The evolutionary change of flash visual evoked potentials in preterm infants with periventricular leukomalacia","volume":"116","author":"Kato","year":"2005","journal-title":"Clin. Neurophysiol."},{"key":"2025031312201629300_r62","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/aji.12216","article-title":"IL-1 receptor blockade prevents fetal cortical brain injury but not preterm birth in a mouse model of inflammation-induced preterm birth and perinatal brain injury","volume":"71","author":"Leitner","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025031312201629300_r63","first-page":"411","article-title":"Perinatal inflammation and infection","volume":"57","author":"Cornette","year":"2005","journal-title":"Minerva Ginecol."},{"key":"2025031312201629300_r64","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cyto.2008.04.007","article-title":"Pro-inflammatory disequilibrium of the IL-1\u03b2\/IL-1ra ratio in an experimental model of perinatal brain damages induced by lipopolysaccharide and hypoxia\u2013ischemia","volume":"43","author":"Girard","year":"2008","journal-title":"Cytokine"},{"key":"2025031312201629300_r65","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1128\/IAI.67.12.6257-6263.1999","article-title":"Induction and regulation of Th1-inducing cytokines by bacterial DNA, lipopolysaccharide, and heat-inactivated bacteria","volume":"67","author":"Huang","year":"1999","journal-title":"Infect. Immun."},{"key":"2025031312201629300_r66","doi-asserted-by":"crossref","first-page":"542.e1","DOI":"10.1016\/j.ajog.2013.08.030","article-title":"The fetal inflammatory response syndrome is a risk factor for morbidity in preterm neonates","volume":"209","author":"Hofer","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r67","doi-asserted-by":"crossref","first-page":"R277","DOI":"10.1530\/REP-16-0453","article-title":"Sterile inflammation and pregnancy complications: a review","volume":"152","author":"Nadeau-Vall\u00e9e","year":"2016","journal-title":"Reproduction"},{"key":"2025031312201629300_r68","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ajog.2005.01.017","article-title":"Chorioamnionitis with a fetal inflammatory response is associated with higher neonatal mortality, morbidity, and resource use than chorioamnionitis displaying a maternal inflammatory response only","volume":"193","author":"Lau","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r69","doi-asserted-by":"crossref","first-page":"F455","DOI":"10.1136\/adc.2007.121327","article-title":"Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate","volume":"93","author":"Bose","year":"2008","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"2025031312201629300_r70","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1084-2756(02)00193-8","article-title":"Pathology of new bronchopulmonary dysplasia","volume":"8","author":"Coalson","year":"2003","journal-title":"Semin. Neonatol."},{"key":"2025031312201629300_r71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1684\/ecn.2012.0304","article-title":"Value of serum and bronchoalveolar fluid lavage pro- and anti-inflammatory cytokine levels for predicting bronchopulmonary dysplasia in premature infants","volume":"23","author":"K\u00f6ksal","year":"2012","journal-title":"Eur. Cytokine Netw."},{"key":"2025031312201629300_r72","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1600-065X.1997.tb00966.x","article-title":"The anatomical basis of intestinal immunity","volume":"156","author":"Mowat","year":"1997","journal-title":"Immunol. Rev."},{"key":"2025031312201629300_r73","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1017\/erm.2016.13","article-title":"The immunological landscape in necrotising enterocolitis","volume":"18","author":"Cho","year":"2016","journal-title":"Expert Rev. Mol. Med."},{"key":"2025031312201629300_r74","first-page":"489","article-title":"Cytokine levels in the preterm infant with neonatal intestinal injury","volume":"31","author":"Bhatia","year":"2014","journal-title":"Am. J. Perinatol."},{"key":"2025031312201629300_r75","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000353721","article-title":"Pilot study using proteomics to identify predictive biomarkers of necrotizing enterocolitis from buccal swabs in very low birth weight infants","volume":"104","author":"Murgas Torrazza","year":"2013","journal-title":"Neonatology"},{"key":"2025031312201629300_r76","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1093\/jn\/134.6.1467","article-title":"Onset of small intestinal atrophy is associated with reduced intestinal blood flow in TPN-fed neonatal piglets","volume":"134","author":"Niinikoski","year":"2004","journal-title":"J. Nutr."},{"key":"2025031312201629300_r77","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/0148607199023006337","article-title":"Total parenteral nutrition alters molecular and cellular indices of intestinal inflammation in neonatal piglets","volume":"23","author":"Ganessunker","year":"1999","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"2025031312201629300_r78","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/cr.2010.175","article-title":"NF-\u03baB in the regulation of epithelial homeostasis and inflammation","volume":"21","author":"Wullaert","year":"2011","journal-title":"Cell Res."},{"key":"2025031312201629300_r79","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000047091","article-title":"Chorioamnionitis and fetal\/neonatal brain injury","volume":"79","author":"Toti","year":"2001","journal-title":"Biol. Neonate"},{"key":"2025031312201629300_r80","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.clp.2013.10.009","article-title":"Chorioamnionitis in the pathogenesis of brain injury in preterm infants","volume":"41","author":"Chau","year":"2014","journal-title":"Clin. Perinatol."},{"key":"2025031312201629300_r81","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/1568007033482742","article-title":"The interleukin-1 system: an attractive and viable therapeutic target in neurodegenerative disease","volume":"2","author":"Allan","year":"2003","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"key":"2025031312201629300_r82","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/1099800409344619","article-title":"Integrated review of cytokines in maternal, cord, and newborn blood: part II\u2014associations with early infection and increased risk of neurologic damage in preterm infants","volume":"11","author":"Pickler","year":"2010","journal-title":"Biol. Res. Nurs."},{"key":"2025031312201629300_r83","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/nm1336","article-title":"Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration","volume":"11","author":"Kermorvant-Duchemin","year":"2005","journal-title":"Nat. Med."},{"key":"2025031312201629300_r84","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1161\/01.STR.0000245082.19294.ff","article-title":"Hyperoxic exposure leads to nitrative stress and ensuing microvascular degeneration and diminished brain mass and function in the immature subject","volume":"37","author":"Sirinyan","year":"2006","journal-title":"Stroke"},{"key":"2025031312201629300_r85","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1016\/j.clinph.2008.08.020","article-title":"Habituation of visual evoked potentials in healthy infants and in infants with periventricular leukomalacia","volume":"119","author":"Gonz\u00e1lez-Frankenberger","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"2025031312201629300_r86","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.4049\/jimmunol.0903349","article-title":"IL-1 receptor antagonist protects against placental and neurodevelopmental defects induced by maternal inflammation","volume":"184","author":"Girard","year":"2010","journal-title":"J. Immunol."},{"key":"2025031312201629300_r87","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1001\/jama.290.20.2677","article-title":"Chorioamnionitis and cerebral palsy in term and near-term infants","volume":"290","author":"Wu","year":"2003","journal-title":"JAMA"},{"key":"2025031312201629300_r88","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/jnr.22368","article-title":"Inflammation-induced preterm birth alters neuronal morphology in the mouse fetal brain","volume":"88","author":"Burd","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"2025031312201629300_r89","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ijdevneu.2011.02.011","article-title":"Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury","volume":"29","author":"Elovitz","year":"2011","journal-title":"Int. J. Dev. Neurosci."},{"key":"2025031312201629300_r90","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1177\/1933719111398498","article-title":"A mouse model of term chorioamnionitis: unraveling causes of adverse neurological outcomes","volume":"18","author":"Burd","year":"2011","journal-title":"Reprod. Sci."},{"key":"2025031312201629300_r91","doi-asserted-by":"crossref","first-page":"49.e1","DOI":"10.1016\/j.ajog.2007.06.011","article-title":"The relationship between intrapartum maternal fever and neonatal acidosis as risk factors for neonatal encephalopathy","volume":"198","author":"Impey","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025031312201629300_r92","doi-asserted-by":"crossref","first-page":"282","DOI":"10.2350\/09-06-0659-OA.1","article-title":"Placental chorioamnionitis at term: epidemiology and follow-up in childhood","volume":"13","author":"Becroft","year":"2010","journal-title":"Pediatr. Dev. Pathol."},{"key":"2025031312201629300_r93","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/jama.1997.03550030047032","article-title":"Maternal infection and cerebral palsy in infants of normal birth weight","volume":"278","author":"Grether","year":"1997","journal-title":"JAMA"},{"key":"2025031312201629300_r94","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1542\/peds.2006-0278","article-title":"Cerebral palsy in a term population: risk factors and neuroimaging findings","volume":"118","author":"Wu","year":"2006","journal-title":"Pediatrics"},{"key":"2025031312201629300_r95","volume-title":"A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery","author":"Kenakin","year":"2014","edition":"4th"},{"key":"2025031312201629300_r96","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/aji.12444","article-title":"Transplacental transfer of interleukin-1 receptor agonist and antagonist following maternal immune activation","volume":"75","author":"Girard","year":"2016","journal-title":"Am. J. Reprod. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/198\/5\/2047\/62398841\/1601600.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/198\/5\/2047\/62398841\/1601600.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T09:29:10Z","timestamp":1741858150000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/198\/5\/2047\/7955023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":96,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1601600","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727261720.793534049","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,3]]},"published":{"date-parts":[[2017,3,1]]}}}