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This review will discuss how CD4 T cell responses directed against an exogenous Ag can cause an autoreactive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. 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Immunol."},{"key":"2025030615091864500_r43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00251-012-0599-z","article-title":"Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules","volume":"64","author":"Sollid","year":"2012","journal-title":"Immunogenetics"},{"key":"2025030615091864500_r44","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrm1014","article-title":"Transglutaminases: crosslinking enzymes with pleiotropic functions","volume":"4","author":"Lorand","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025030615091864500_r45","first-page":"246","article-title":"Autoantibodies as markers of coeliac disease autoimmunity. In Seventh International Symposium on Coeliac Disease","author":"M\u00e4ki","year":"1992"},{"key":"2025030615091864500_r46","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/gut.41.6.851","article-title":"Autoantibodies in coeliac disease: tissue transglutaminase--guilt by association?","volume":"41","author":"Sollid","year":"1997","journal-title":"Gut"},{"key":"2025030615091864500_r47","doi-asserted-by":"crossref","first-page":"e0134922","DOI":"10.1371\/journal.pone.0134922","article-title":"Enhanced B-cell receptor recognition of the autoantigen transglutaminase 2 by efficient catalytic self-multimerization","volume":"10","author":"Stamnaes","year":"2015","journal-title":"PLoS One"},{"key":"2025030615091864500_r48","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.4049\/jimmunol.1501363","article-title":"Igs as substrates for transglutaminase 2: implications for autoantibody production in celiac disease","volume":"195","author":"Iversen","year":"2015","journal-title":"J. Immunol."},{"key":"2025030615091864500_r49","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/039463201002300116","article-title":"Isolation and characterization of circulating tissue transglutaminase-specific T cells in coeliac disease","volume":"23","author":"Ciccocioppo","year":"2010","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"2025030615091864500_r50","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.clim.2014.08.001","article-title":"Characterisation of tissue transglutaminase-reactive T cells from patients with coeliac disease and healthy controls","volume":"154","author":"Comerford","year":"2014","journal-title":"Clin. Immunol."},{"key":"2025030615091864500_r51","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF00229084","article-title":"Differential expression of tissue transglutaminase in human cells. An immunohistochemical study","volume":"255","author":"Thom\u00e1zy","year":"1989","journal-title":"Cell Tissue Res."},{"key":"2025030615091864500_r52","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0014-5793(97)00140-3","article-title":"Differential expression of tissue transglutaminase during in vivo apoptosis of thymocytes induced via distinct signalling pathways","volume":"404","author":"Szondy","year":"1997","journal-title":"FEBS Lett."},{"key":"2025030615091864500_r53","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1172\/JCI27620","article-title":"HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease","volume":"116","author":"Tollefsen","year":"2006","journal-title":"J. Clin. 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Pharmacol. Exp. Ther."},{"key":"2025030615091864500_r88","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3109\/00365529309096094","article-title":"Follow-up of patients positive in reticulin and gliadin antibody tests with normal small-bowel biopsy findings","volume":"28","author":"Collin","year":"1993","journal-title":"Scand. J. Gastroenterol."},{"key":"2025030615091864500_r89","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ajg.2014.77","article-title":"Potential celiac children: 9-year follow-up on a gluten-containing diet","volume":"109","author":"Auricchio","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"2025030615091864500_r90","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1172\/JCI200421055","article-title":"A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice","volume":"114","author":"Marietta","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2025030615091864500_r91","doi-asserted-by":"crossref","first-page":"7440","DOI":"10.4049\/jimmunol.0900233","article-title":"Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells","volume":"182","author":"de Kauwe","year":"2009","journal-title":"J. Immunol."},{"key":"2025030615091864500_r92","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0016-5085(00)70173-9","article-title":"Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease","volume":"118","author":"Jabri","year":"2000","journal-title":"Gastroenterology"},{"key":"2025030615091864500_r93","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.4049\/jimmunol.167.10.5527","article-title":"NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment","volume":"167","author":"Roberts","year":"2001","journal-title":"J. Immunol."},{"key":"2025030615091864500_r94","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0140-6736(03)14027-5","article-title":"Coeliac disease","volume":"362","author":"Green","year":"2003","journal-title":"Lancet"},{"key":"2025030615091864500_r95","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.immuni.2004.06.018","article-title":"A direct role for NKG2D\/MICA interaction in villous atrophy during celiac disease","volume":"21","author":"H\u00fce","year":"2004","journal-title":"Immunity"},{"key":"2025030615091864500_r96","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2004.06.020","article-title":"Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease","volume":"21","author":"Meresse","year":"2004","journal-title":"Immunity"},{"key":"2025030615091864500_r97","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1084\/jem.20060028","article-title":"Reprogramming of CTLs into natural killer-like cells in celiac disease","volume":"203","author":"Meresse","year":"2006","journal-title":"J. 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Immunol."},{"key":"2025030615091864500_r104","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.4049\/jimmunol.166.6.3923","article-title":"The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T cells: clones sharing identical \u03b1 \u03b2 TCR rearrangement express highly diverse killer cell Ig-like receptor patterns","volume":"166","author":"Uhrberg","year":"2001","journal-title":"J. Immunol."},{"key":"2025030615091864500_r105","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nri1901","article-title":"The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design","volume":"6","author":"Waldmann","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2025030615091864500_r106","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1084\/jem.20150303","article-title":"Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease","volume":"212","author":"Tang","year":"2015","journal-title":"J. Exp. Med."},{"key":"2025030615091864500_r107","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1084\/jem.20071887","article-title":"Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15","volume":"206","author":"Tang","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025030615091864500_r108","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1126\/science.285.5428.730","article-title":"An activating immunoreceptor complex formed by NKG2D and DAP10","volume":"285","author":"Wu","year":"1999","journal-title":"Science"},{"key":"2025030615091864500_r109","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.285.5428.727","article-title":"Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA","volume":"285","author":"Bauer","year":"1999","journal-title":"Science"},{"key":"2025030615091864500_r110","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35869","article-title":"HLA-E binds to natural killer cell receptors CD94\/NKG2A, B and C","volume":"391","author":"Braud","year":"1998","journal-title":"Nature"},{"key":"2025030615091864500_r111","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1073\/pnas.95.9.5199","article-title":"HLA-E is a major ligand for the natural killer inhibitory receptor CD94\/NKG2A","volume":"95","author":"Lee","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030615091864500_r112","doi-asserted-by":"crossref","first-page":"8158","DOI":"10.1073\/pnas.1301022110","article-title":"IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner","volume":"110","author":"Liu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030615091864500_r113","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/eji.1830230231","article-title":"Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ \u03b1\/\u03b2 cells in the lamina propria but proliferation (Ki-67) of \u03b1\/\u03b2 and \u03b3\/\u03b4 cells in the epithelium","volume":"23","author":"Halstensen","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"2025030615091864500_r114","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1084\/jem.175.1.57","article-title":"Oligoclonality of human intestinal intraepithelial T cells","volume":"175","author":"Van Kerckhove","year":"1992","journal-title":"J. Exp. Med."},{"key":"2025030615091864500_r115","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.4049\/jimmunol.150.11.5144","article-title":"Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple V \u03b2 T cell receptor genes","volume":"150","author":"Blumberg","year":"1993","journal-title":"J. Immunol."},{"key":"2025030615091864500_r116","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2174\/138945010791011910","article-title":"Targeting interleukin-21 in immune-mediated pathologies","volume":"11","author":"Sarra","year":"2010","journal-title":"Curr. 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