{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:16:36Z","timestamp":1780913796192,"version":"3.54.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Concurrent helminth infection potently inhibits T cell immunity; however, whether helminthes prevent T cell priming or skew clonal recruitment and effector differentiation is not known. Using coinfection with two natural mouse pathogens, Heligmosomoides polygyrus and Toxoplasma gondii, to investigate the negative impact of helminthes on the CD8 T cell response, we demonstrate helminth-induced suppression of IL-12\u2013dependent differentiation of killer-like receptor G1+ effector CD8 T cells and IFN-\u03b3 production. Nevertheless, reversal of helminth suppression of the innate IL-12 response of CD8\u03b1+ dendritic cells, which occurred in STAT6-deficient mice, was not sufficient to normalize CD8 T cell differentiation. Instead, a combined deficiency in IL-4 and IL-10 was required to reverse the negative effects of helminth coinfection on the CD8 T cell response. Monoclonal T. gondii\u2013specific CD8 T cells adoptively transferred into coinfected mice recapitulated the spectrum of helminth-induced effects on the polyclonal CD8 T response, indicating the lack of requirement for clonal skewing.<\/jats:p>","DOI":"10.4049\/jimmunol.1601741","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T02:30:42Z","timestamp":1481596242000},"page":"634-639","source":"Crossref","is-referenced-by-count":24,"title":["Cutting Edge: Helminth Coinfection Blocks Effector Differentiation of CD8 T Cells through Alternate Host Th2- and IL-10\u2013Mediated Responses"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6724-8399","authenticated-orcid":false,"given":"Andrew","family":"Marple","sequence":"first","affiliation":[{"name":"Department of Medicine, Rutgers New Jersey Medical School , Newark, NJ 07101"},{"name":"Center for Immunity and Inflammation, Rutgers New Jersey Medical School , Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rutgers New Jersey Medical School , Newark, NJ 07101"},{"name":"Center for Immunity and Inflammation, Rutgers New Jersey Medical School , Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3352-7274","authenticated-orcid":false,"given":"Suhagi","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rutgers New Jersey Medical School , Newark, NJ 07101"},{"name":"Center for Immunity and Inflammation, Rutgers New Jersey Medical School , Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-7543","authenticated-orcid":false,"given":"Yanlin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rutgers New Jersey Medical School , Newark, NJ 07101"},{"name":"Center for Immunity and Inflammation, Rutgers New Jersey Medical School , Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4367-0875","authenticated-orcid":false,"given":"Peicheng","family":"Du","sequence":"additional","affiliation":[{"name":"High Performance and Research Computing Group, Office of Information Technology, Rutgers New Jersey Medical School, Rutgers University , Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C","family":"Gause","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rutgers New Jersey Medical School , Newark, NJ 07101"},{"name":"Center for Immunity and Inflammation, Rutgers New Jersey Medical School , Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George S","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rutgers New Jersey Medical School , Newark, NJ 07101"},{"name":"Center for Immunity and Inflammation, Rutgers New Jersey Medical School , Newark, NJ 07101"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,15]]},"reference":[{"key":"2025030614581982100_r1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.pt.2003.10.002","article-title":"Soil-transmitted helminth infections: updating the global picture","volume":"19","author":"de Silva","year":"2003","journal-title":"Trends Parasitol."},{"key":"2025030614581982100_r2","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ni.2736","article-title":"Effect of helminth-induced immunity on infections with microbial pathogens","volume":"14","author":"Salgame","year":"2013","journal-title":"Nat. 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