{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:20:03Z","timestamp":1776270003697,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rap1-interacting adaptor molecule (RIAM) is a Rap1 effector that mediates the recruitment of talin to integrins, thereby supporting their activation. In this study, we investigated the role of RIAM in an adoptive transfer model for type I diabetes and report that RIAM expression in T cells is necessary for diabetes development. Loss of RIAM did not prevent lymphocyte recruitment to draining lymph nodes 24 h after transfer, but it was required for Ag-driven proliferation and cytotoxic killing. RIAM is recruited to immune synapses along with talin and LFA-1, and loss of RIAM profoundly suppresses Ag-dependent conjugate formation in primary naive and effector T cells. These data identify the requirement of RIAM for formation of immunological synapses and in resulting T cell functions in autoimmunity. Moreover, because RIAM-null mice are healthy, fertile, and display no bleeding abnormalities, our results identify RIAM and its regulators as potential targets for therapies of T cell\u2013mediated autoimmunity.<\/jats:p>","DOI":"10.4049\/jimmunol.1601743","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:31:23Z","timestamp":1490661083000},"page":"3410-3415","source":"Crossref","is-referenced-by-count":15,"title":["Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes"],"prefix":"10.1093","volume":"198","author":[{"given":"Frederic","family":"Lagarrigue","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank B","family":"Gertler","sequence":"additional","affiliation":[{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, MA 02142"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M","family":"Cantor","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"2025030615115784000_r1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00125-003-1089-5","article-title":"The role of T-cells in the pathogenesis of type 1 diabetes: from cause to cure","volume":"46","author":"Roep","year":"2003","journal-title":"Diabetologia"},{"key":"2025030615115784000_r2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1242\/jcs.019117","article-title":"Integrins in immunity","volume":"122","author":"Evans","year":"2009","journal-title":"J. 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