{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:41:56Z","timestamp":1791333716517,"version":"4.3.1"},"reference-count":96,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Inhibitor of DNA binding (Id) proteins, including Id1\u20134, are transcriptional regulators involved in promoting cell proliferation and survival in various cell types. Although upregulation of Id proteins is associated with a broad spectrum of tumors, recent studies have identified that Id3 plays a tumor-suppressor role in the development of Burkitt\u2019s lymphoma in humans and hepatosplenic T cell lymphomas in mice. In this article, we report rapid lymphoma development in Id2\/Id3 double-knockout mice that is caused by unchecked expansion of invariant NKT (iNKT) cells or a unique subset of innate-like CD1d-independent T cells. These populations began to expand in neonatal mice and, upon malignant transformation, resulted in mortality between 3 and 11 mo of age. The malignant cells also gave rise to lymphomas upon transfer to Rag-deficient and wild-type hosts, reaffirming their inherent tumorigenic potential. Microarray analysis revealed a significantly modified program in these neonatal iNKT cells that ultimately led to their malignant transformation. The lymphoma cells demonstrated chromosome instability along with upregulation of several signaling pathways, including the cytokine\u2013cytokine receptor interaction pathway, which can promote their expansion and migration. Dysregulation of genes with reported driver mutations and the NF-\u03baB pathway were found to be shared between Id2\/Id3 double-knockout lymphomas and human NKT tumors. Our work identifies a distinct premalignant state and multiple tumorigenic pathways caused by loss of function of Id2 and Id3. Thus, conditional deletion of Id2 and Id3 in developing T cells establishes a unique animal model for iNKT and relevant innate-like lymphomas.<\/jats:p>","DOI":"10.4049\/jimmunol.1601935","type":"journal-article","created":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T01:50:20Z","timestamp":1488592220000},"page":"3136-3148","source":"Crossref","is-referenced-by-count":20,"title":["Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-8635","authenticated-orcid":false,"given":"Jia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Immunology, Duke University Medical Center , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumedha","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Immunology, Duke University Medical Center , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-0071","authenticated-orcid":false,"given":"Young-Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oklahoma University Health Sciences Center , Oklahoma City, OK 73014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oklahoma University Health Sciences Center , Oklahoma City, OK 73014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-4304","authenticated-orcid":false,"given":"Baojun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Duke University Medical Center , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Love","sequence":"additional","affiliation":[{"name":"Duke Institute for Genome Sciences and Policy, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Reddy","sequence":"additional","affiliation":[{"name":"Duke Institute for Genome Sciences and Policy, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthi","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Duke Institute for Genome Sciences and Policy, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Dave","sequence":"additional","affiliation":[{"name":"Duke Institute for Genome Sciences and Policy, Duke University , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Mae","family":"Diehl","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University Medical Center , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Duke University Medical Center , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,15]]},"reference":[{"key":"2025030615091660400_r1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"2025030615091660400_r2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/CCO.0b013e32835b651e","article-title":"Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy","volume":"25","author":"Hainaut","year":"2013","journal-title":"Curr. Opin. Oncol."},{"key":"2025030615091660400_r3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nrc3742","article-title":"Imaging hallmarks of cancer in living mice","volume":"14","author":"Ellenbroek","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"2025030615091660400_r4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35077213","article-title":"Proliferation, cell cycle and apoptosis in cancer","volume":"411","author":"Evan","year":"2001","journal-title":"Nature"},{"key":"2025030615091660400_r5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","article-title":"The biology of cancer: metabolic reprogramming fuels cell growth and proliferation","volume":"7","author":"DeBerardinis","year":"2008","journal-title":"Cell Metab."},{"key":"2025030615091660400_r6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrc1673","article-title":"Id family of helix-loop-helix proteins in cancer","volume":"5","author":"Perk","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"2025030615091660400_r7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrc3638","article-title":"The ID proteins: master regulators of cancer stem cells and tumour aggressiveness","volume":"14","author":"Lasorella","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"2025030615091660400_r8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4161\/cbt.50","article-title":"Id proteins--tumor markers or oncogenes?","volume":"1","author":"Hasskarl","year":"2002","journal-title":"Cancer Biol. Ther."},{"key":"2025030615091660400_r9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.gene.2008.02.015","article-title":"Autocrine BMP4 signalling regulates ID3 proto-oncogene expression in human ovarian cancer cells","volume":"414","author":"Shepherd","year":"2008","journal-title":"Gene"},{"key":"2025030615091660400_r10","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1158\/1541-7786.MCR-10-0535","article-title":"The Id3\/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma","volume":"9","author":"Lee","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"2025030615091660400_r11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.ccr.2012.04.036","article-title":"ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21","volume":"21","author":"O\u2019Brien","year":"2012","journal-title":"Cancer Cell"},{"key":"2025030615091660400_r12","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/carcin\/bgt479","article-title":"Id2, Id3 and Id4 overcome a Smad7-mediated block in tumorigenesis, generating TGF-\u03b2\u2013independent melanoma","volume":"35","author":"DiVito","year":"2014","journal-title":"Carcinogenesis"},{"key":"2025030615091660400_r13","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1349-7006.2005.00113.x","article-title":"Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer","volume":"96","author":"Tsuchiya","year":"2005","journal-title":"Cancer Sci."},{"key":"2025030615091660400_r14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/cam4.19","article-title":"Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B","volume":"1","author":"Sharma","year":"2012","journal-title":"Cancer Med."},{"key":"2025030615091660400_r15","first-page":"595","article-title":"Inhibition of tumourigenicity of small cell lung cancer cells by suppressing Id3 expression","volume":"37","author":"Kamalian","year":"2010","journal-title":"Int. J. Oncol."},{"key":"2025030615091660400_r16","doi-asserted-by":"crossref","first-page":"7192","DOI":"10.1038\/onc.2008.356","article-title":"Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver","volume":"27","author":"Gray","year":"2008","journal-title":"Oncogene"},{"key":"2025030615091660400_r17","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/ng.2468","article-title":"The genetic landscape of mutations in Burkitt lymphoma","volume":"44","author":"Love","year":"2012","journal-title":"Nat. Genet."},{"key":"2025030615091660400_r18","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/ng.2469","article-title":"Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing","volume":"44","author":"Richter","year":"2012","journal-title":"Nat. Genet."},{"key":"2025030615091660400_r19","doi-asserted-by":"crossref","first-page":"a014282","DOI":"10.1101\/cshperspect.a014282","article-title":"Oncogenic mechanisms in Burkitt lymphoma","volume":"4","author":"Schmitz","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"2025030615091660400_r20","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1182\/blood-2010-03-274506","article-title":"Mutation of inhibitory helix-loop-helix protein Id3 causes \u03b3\u03b4 T-cell lymphoma in mice","volume":"116","author":"Li","year":"2010","journal-title":"Blood"},{"key":"2025030615091660400_r21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ng1521","article-title":"Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia","volume":"37","author":"Yu","year":"2005","journal-title":"Nat. Genet."},{"key":"2025030615091660400_r22","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1182\/blood-2010-05-284638","article-title":"Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL","volume":"117","author":"Chen","year":"2011","journal-title":"Blood"},{"key":"2025030615091660400_r23","doi-asserted-by":"crossref","first-page":"147ra112","DOI":"10.1126\/scitranslmed.3003778","article-title":"Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4","volume":"4","author":"Ren","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"2025030615091660400_r24","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1158\/0008-5472.CAN-04-2095","article-title":"Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium","volume":"64","author":"Russell","year":"2004","journal-title":"Cancer Res."},{"key":"2025030615091660400_r25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0092-8674(90)90214-Y","article-title":"The protein Id: a negative regulator of helix-loop-helix DNA binding proteins","volume":"61","author":"Benezra","year":"1990","journal-title":"Cell"},{"key":"2025030615091660400_r26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35105060","article-title":"The function of E- and Id proteins in lymphocyte development","volume":"1","author":"Engel","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"2025030615091660400_r27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nri2507","article-title":"E and ID proteins branch out","volume":"9","author":"Kee","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"2025030615091660400_r28","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.4049\/jimmunol.0804249","article-title":"Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis","volume":"182","author":"Ueda-Hayakawa","year":"2009","journal-title":"J. Immunol."},{"key":"2025030615091660400_r29","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.coi.2010.12.016","article-title":"Development of PLZF-expressing innate T cells","volume":"23","author":"Alonzo","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"2025030615091660400_r30","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.4049\/jimmunol.0903218","article-title":"Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3","volume":"184","author":"Alonzo","year":"2010","journal-title":"J. Immunol."},{"key":"2025030615091660400_r31","doi-asserted-by":"crossref","first-page":"e9303","DOI":"10.1371\/journal.pone.0009303","article-title":"Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent \u201cinnate\u201d gammadelta T cells","volume":"5","author":"Verykokakis","year":"2010","journal-title":"PLoS One"},{"key":"2025030615091660400_r32","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.4049\/jimmunol.1301521","article-title":"Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development","volume":"191","author":"Verykokakis","year":"2013","journal-title":"J. Immunol."},{"key":"2025030615091660400_r33","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.4049\/jimmunol.1302694","article-title":"Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like \u03b3\u03b4 T cells","volume":"192","author":"Zhang","year":"2014","journal-title":"J. Immunol."},{"key":"2025030615091660400_r34","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.4049\/jimmunol.1301252","article-title":"Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion","volume":"191","author":"Li","year":"2013","journal-title":"J. Immunol."},{"key":"2025030615091660400_r35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1615\/CritRevImmunol.2015012207","article-title":"Orchestration of invariant natural killer T cell development by E and Id proteins","volume":"35","author":"Roy","year":"2015","journal-title":"Crit. Rev. Immunol."},{"key":"2025030615091660400_r36","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.4049\/jimmunol.1302904","article-title":"E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation","volume":"192","author":"D\u2019Cruz","year":"2014","journal-title":"J. Immunol."},{"key":"2025030615091660400_r37","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.4049\/jimmunol.1301546","article-title":"Increased level of E protein activity during invariant NKT development promotes differentiation of invariant NKT2 and invariant NKT17 subsets","volume":"191","author":"Hu","year":"2013","journal-title":"J. Immunol."},{"key":"2025030615091660400_r38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/35105052","article-title":"Autoreactivity by design: innate B and T lymphocytes","volume":"1","author":"Bendelac","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"2025030615091660400_r39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc1252","article-title":"Cytokines in cancer pathogenesis and cancer therapy","volume":"4","author":"Dranoff","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"2025030615091660400_r40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nri3174","article-title":"Targeting natural killer cells and natural killer T cells in cancer","volume":"12","author":"Vivier","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2025030615091660400_r41","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI200423594","article-title":"Going both ways: immune regulation via CD1d-dependent NKT cells","volume":"114","author":"Godfrey","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2025030615091660400_r42","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1084\/jem.2118insight3","article-title":"The in-betweeners: MAIT cells join the innate-like lymphocytes gang","volume":"211","author":"Margulies","year":"2014","journal-title":"J. Exp. Med."},{"key":"2025030615091660400_r43","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.25.022106.141711","article-title":"The biology of NKT cells","volume":"25","author":"Bendelac","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"2025030615091660400_r44","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0145-2126(03)00024-9","article-title":"Immunoprofiling of cell lines derived from natural killer-cell and natural killer-like T-cell leukemia-lymphoma","volume":"27","author":"Matsuo","year":"2003","journal-title":"Leuk. Res."},{"key":"2025030615091660400_r45","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2025030615091660400_r46","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1008-1091","article-title":"The Immunological Genome Project: networks of gene expression in immune cells","volume":"9","author":"Heng","year":"2008","journal-title":"Nat. Immunol."},{"key":"2025030615091660400_r47","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/1471-2105-10-358","article-title":"ArrayMining: a modular web-application for microarray analysis combining ensemble and consensus methods with cross-study normalization","volume":"10","author":"Glaab","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"2025030615091660400_r48","doi-asserted-by":"crossref","first-page":"e101717","DOI":"10.1371\/journal.pone.0101717","article-title":"eulerAPE: drawing area-proportional 3-Venn diagrams using ellipses","volume":"9","author":"Micallef","year":"2014","journal-title":"PLos ONE"},{"key":"2025030615091660400_r49","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"2025030615091660400_r50","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1101\/gad.255331.114","article-title":"The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc\/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis","volume":"29","author":"Miyazaki","year":"2015","journal-title":"Genes Dev."},{"key":"2025030615091660400_r51","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.1641","article-title":"The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions","volume":"9","author":"Kovalovsky","year":"2008","journal-title":"Nat. Immunol."},{"key":"2025030615091660400_r52","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.immuni.2010.07.013","article-title":"SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics","volume":"33","author":"Verykokakis","year":"2010","journal-title":"Immunity"},{"key":"2025030615091660400_r53","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/ni.2086","article-title":"The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells","volume":"12","author":"Miyazaki","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025030615091660400_r54","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri1309","article-title":"NKT cells: what\u2019s in a name?","volume":"4","author":"Godfrey","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"2025030615091660400_r55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-4827(02)00016-2","article-title":"Apoptosis by Par-4 in cancer and neurodegenerative diseases","volume":"283","author":"El-Guendy","year":"2003","journal-title":"Exp. Cell Res."},{"key":"2025030615091660400_r56","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/378736a0","article-title":"Apoptosis of T cells mediated by galectin-1","volume":"378","author":"Perillo","year":"1995","journal-title":"Nature"},{"key":"2025030615091660400_r57","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.immuni.2010.05.010","article-title":"Tumor-induced tolerance and immune suppression depend on the C\/EBPbeta transcription factor","volume":"32","author":"Marigo","year":"2010","journal-title":"Immunity"},{"key":"2025030615091660400_r58","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1073\/pnas.0611559104","article-title":"Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression","volume":"104","author":"Yanai","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030615091660400_r59","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.4049\/jimmunol.1100495","article-title":"Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development","volume":"187","author":"Shen","year":"2011","journal-title":"J. Immunol."},{"key":"2025030615091660400_r60","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1158\/2159-8290.CD-12-0215","article-title":"Diacylglycerol kinase \u03b1 is a critical signaling node and novel therapeutic target in glioblastoma and other cancers","volume":"3","author":"Dominguez","year":"2013","journal-title":"Cancer Discov."},{"key":"2025030615091660400_r61","doi-asserted-by":"crossref","first-page":"22627","DOI":"10.1074\/jbc.C000235200","article-title":"Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase","volume":"275","author":"Ohki","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2025030615091660400_r62","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/onc.2012.147","article-title":"PTPN14 interacts with and negatively regulates the oncogenic function of YAP","volume":"32","author":"Liu","year":"2013","journal-title":"Oncogene"},{"key":"2025030615091660400_r63","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/jcp.21919","article-title":"The mammalian anti-proliferative BTG\/Tob protein family","volume":"222","author":"Winkler","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"2025030615091660400_r64","first-page":"4800","article-title":"PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-\u03baB- and HDAC1-mediated expression and activation of uPA","volume":"125","author":"Zou","year":"2012","journal-title":"J. Cell Sci."},{"key":"2025030615091660400_r65","doi-asserted-by":"crossref","first-page":"7621","DOI":"10.1158\/1078-0432.CCR-04-1061","article-title":"Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis","volume":"10","author":"Pellikainen","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"2025030615091660400_r66","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1038\/sj.onc.1204422","article-title":"Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth","volume":"20","author":"Oehler","year":"2001","journal-title":"Oncogene"},{"key":"2025030615091660400_r67","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/bjc.1993.298","article-title":"Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies","volume":"68","author":"Banks","year":"1993","journal-title":"Br. J. Cancer"},{"key":"2025030615091660400_r68","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.4049\/jimmunol.171.6.2960","article-title":"Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets","volume":"171","author":"Johnston","year":"2003","journal-title":"J. Immunol."},{"key":"2025030615091660400_r69","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ni.1845","article-title":"An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells","volume":"11","author":"D\u2019Cruz","year":"2010","journal-title":"Nat. Immunol."},{"key":"2025030615091660400_r70","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1084\/jem.20030141","article-title":"NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells","volume":"197","author":"Elewaut","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025030615091660400_r71","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.canlet.2004.12.028","article-title":"Centrosome amplification, chromosome instability and cancer development","volume":"230","author":"Fukasawa","year":"2005","journal-title":"Cancer Lett."},{"key":"2025030615091660400_r72"},{"key":"2025030615091660400_r73","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/j.1349-7006.2007.00606.x","article-title":"Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response","volume":"98","author":"Koizumi","year":"2007","journal-title":"Cancer Sci."},{"key":"2025030615091660400_r74","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nri3049","article-title":"Homeostatic chemokine receptors and organ-specific metastasis","volume":"11","author":"Zlotnik","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"2025030615091660400_r75","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/eji.200324718","article-title":"Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells","volume":"34","author":"Franitza","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"2025030615091660400_r76","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.4049\/jimmunol.162.9.5094","article-title":"Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells","volume":"162","author":"Emoto","year":"1999","journal-title":"J. Immunol."},{"key":"2025030615091660400_r77","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","article-title":"CXCL12 (SDF-1)\/CXCR4 pathway in cancer","volume":"16","author":"Teicher","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"2025030615091660400_r78","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/039463201002300114","article-title":"Clinicopathological and therapeutic significance of CXCL12 expression in lung cancer","volume":"23","author":"Imai","year":"2010","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"2025030615091660400_r79","doi-asserted-by":"crossref","first-page":"9160","DOI":"10.1073\/pnas.0508892103","article-title":"A unique lymphotoxin alphabeta-dependent pathway regulates thymic emigration of Valpha14 invariant natural killer T cells","volume":"103","author":"Franki","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030615091660400_r80","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1158\/0008-5472.CAN-05-3558","article-title":"Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo","volume":"66","author":"Blyth","year":"2006","journal-title":"Cancer Res."},{"key":"2025030615091660400_r81","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","article-title":"New functions for the matrix metalloproteinases in cancer progression","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"2025030615091660400_r82","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0092-8674(00)81009-0","article-title":"The stromal proteinase MMP3\/stromelysin-1 promotes mammary carcinogenesis","volume":"98","author":"Sternlicht","year":"1999","journal-title":"Cell"},{"key":"2025030615091660400_r83","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1182\/blood-2009-12-257030","article-title":"EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth","volume":"116","author":"Bouchard","year":"2010","journal-title":"Blood"},{"key":"2025030615091660400_r84","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ncb2490","article-title":"Id proteins synchronize stemness and anchorage to the niche of neural stem cells","volume":"14","author":"Niola","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"2025030615091660400_r85","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1182\/blood-2005-11-4334","article-title":"Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival","volume":"107","author":"Starlets","year":"2006","journal-title":"Blood"},{"key":"2025030615091660400_r86","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1002\/ijc.24721","article-title":"The novel tumor-suppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance","volume":"125","author":"Wang","year":"2009","journal-title":"Int. J. Cancer"},{"key":"2025030615091660400_r87","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.4049\/jimmunol.1400993","article-title":"Differential requirement for CCR4 and CCR7 during the development of innate and adaptive \u03b1\u03b2T cells in the adult thymus","volume":"193","author":"Cowan","year":"2014","journal-title":"J. Immunol."},{"key":"2025030615091660400_r88","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ni.1696","article-title":"The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells","volume":"10","author":"Lazarevic","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025030615091660400_r89","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ni.2230","article-title":"Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling. [Published erratum appears in 2013 Nat. Immunol. 14: 413.]","volume":"13","author":"Seiler","year":"2012","journal-title":"Nat. Immunol."},{"key":"2025030615091660400_r90","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ng.3358","article-title":"Exome sequencing identifies somatic mutations of DDX3X in natural killer\/T-cell lymphoma","volume":"47","author":"Jiang","year":"2015","journal-title":"Nat. Genet."},{"key":"2025030615091660400_r91","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1084\/jem.20150794","article-title":"CD1d-restricted peripheral T cell lymphoma in mice and humans","volume":"213","author":"Bachy","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025030615091660400_r92","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.cyto.2014.06.009","article-title":"Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice","volume":"69","author":"Belle","year":"2014","journal-title":"Cytokine"},{"key":"2025030615091660400_r93","doi-asserted-by":"crossref","first-page":"673","DOI":"10.4049\/jimmunol.1302058","article-title":"Innate PLZF+CD4+ \u03b1\u03b2 T cells develop and expand in the absence of Itk","volume":"193","author":"Prince","year":"2014","journal-title":"J. Immunol."},{"key":"2025030615091660400_r94","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1172\/JCI43242","article-title":"NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human","volume":"121","author":"Yu","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2025030615091660400_r95","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1182\/blood-2014-02-555482","article-title":"PLZF staining identifies peripheral T-cell lymphomas derived from innate-like T-cells with TRAV1-2-TRAJ33 TCR-\u03b1 rearrangement","volume":"123","author":"McGregor","year":"2014","journal-title":"Blood"},{"key":"2025030615091660400_r96","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/nar\/27.1.29","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","volume":"27","author":"Ogata","year":"1999","journal-title":"Nucleic Acids Res."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/198\/8\/3136\/61449414\/1601935.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/198\/8\/3136\/61449414\/1601935.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T17:23:59Z","timestamp":1741281839000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/198\/8\/3136\/7954928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":96,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,4,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1601935","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,4]]},"published":{"date-parts":[[2017,4]]}}}