{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:25:37Z","timestamp":1782818737124,"version":"3.54.5"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Leishmaniases are diseases caused by several Leishmania species. Leishmania (Viannia) braziliensis can cause localized cutaneous leishmaniasis (LCL), which heals spontaneously, or mucosal leishmaniasis (ML), characterized by chronic and intense inflammation and scanty parasitism. Annexin A1 (AnxA1) is a protein involved in modulation and resolution of inflammation through multiple mechanisms. In the present study, the role of AnxA1 was investigated in L. braziliensis\u2013infected BALB\/c mice. AnxA1 levels increased at the peak of tissue lesion and parasitism in infected mice. AnxA1 increased also after L. braziliensis infection of BALB\/c (wild-type [WT]) bone marrow\u2002derived macrophages. Despite a lower parasite intake, parasite burden in bone marrow-derived macrophages from AnxA1\u2212\/\u2212 mice was similar to WT and associated with an early increase of TNF-\u03b1 and, later, of IL-10. AnxA1\u2212\/\u2212 mice controlled tissue parasitism similarly to WT animals, but they developed significantly larger lesions at later stages of infection, with a more pronounced inflammatory infiltrate and increased specific production of IFN-\u03b3, IL-4, and IL-10. AnxA1\u2212\/\u2212 mice also presented higher phosphorylation levels of ERK-1\/2 and p65\/RelA (NF-\u03baB) and inducible NO synthase expression, suggesting that AnxA1 may be involved in modulation of inflammation in this model of experimental leishmaniasis. Finally, assessment of AnxA1 levels in sera from patients with LCL or ML revealed that ML patients had higher levels of serum AnxA1 than did LCL patients or control subjects. Collectively, these data indicate that AnxA1 is actively expressed during L. braziliensis infection. In the absence of AnxA1, mice are fully able to control parasite replication, but they present more intense inflammatory responses and delayed ability to resolve their lesion size.<\/jats:p>","DOI":"10.4049\/jimmunol.1602028","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:35:45Z","timestamp":1489451745000},"page":"3227-3236","source":"Crossref","is-referenced-by-count":22,"title":["Annexin A1 Is Involved in the Resolution of Inflammatory Responses during <i>Leishmania braziliensis<\/i> Infection"],"prefix":"10.1093","volume":"198","author":[{"given":"Leandro G","family":"Oliveira","sequence":"first","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais 31270-901,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00edriam C","family":"Souza-Testasicca","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais 31270-901,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8188-3738","authenticated-orcid":false,"given":"Juliana P","family":"Vago","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais 31270-901,","place":["Brazil"]},{"name":"Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais 31270-901","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Braga","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunoparasitologia, N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Ouro Preto , Ouro Preto, Minas Gerais 35400-000,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana M C","family":"Canavaci","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais 31270-901,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Oliveira","family":"Perucci","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais 31270-901,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana P Teixeira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o, Instituto Oswaldo Cruz\/FIOCRUZ , Rio de Janeiro 21040-360,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo A F","family":"Coelho","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais 31270-901,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Utsch","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais , Belo 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