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In this study, the assay for transposase-accessible chromatin sequencing was employed to map the cis-regulatory elements in CD8 T cells responding to acute and chronic lymphocytic choriomeningitis virus infections. Integration of chromatin accessibility profiles with gene expression data identified unique regulatory modules that were enriched for distinct combinations of transcription factor\u2013binding motifs. Memory CD8 T cells displayed a chromatin accessibility structure that was absent from other acute and exhausted cells types and included key effector and proliferative genes. Stimulation of memory cells revealed enhanced transcription of \u201cmemory-primed\u201d genes compared with naive cells. Thus, memory CD8 T cells display a preprogrammed chromatin accessibility profile and maintain a molecular history of cis-element usage, thereby reducing the steps necessary to revive effector functions.<\/jats:p>","DOI":"10.4049\/jimmunol.1602086","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T20:25:30Z","timestamp":1486585530000},"page":"2238-2243","source":"Crossref","is-referenced-by-count":87,"title":["Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7716-8504","authenticated-orcid":false,"given":"Christopher D","family":"Scharer","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322; and , Atlanta, GA 30322"},{"name":"Emory Vaccine Center, Emory University School of Medicine , Atlanta, GA 30322; and , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-5033","authenticated-orcid":false,"given":"Alexander P R","family":"Bally","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322; and , Atlanta, GA 30322"},{"name":"Emory Vaccine Center, Emory University School of Medicine , Atlanta, GA 30322; and , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-1062","authenticated-orcid":false,"given":"Bhanu","family":"Gandham","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322; and , Atlanta, GA 30322"},{"name":"Emory Vaccine Center, Emory University School of Medicine , Atlanta, GA 30322; and , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-1840","authenticated-orcid":false,"given":"Jeremy M","family":"Boss","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA 30322; and , Atlanta, GA 30322"},{"name":"Emory Vaccine Center, Emory University School of Medicine , Atlanta, GA 30322; and , Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"2025030615053978000_r1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/76907","article-title":"Response of na\u00efve and memory CD8+ T cells to antigen stimulation in vivo","volume":"1","author":"Veiga-Fernandes","year":"2000","journal-title":"Nat. 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