{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:03:05Z","timestamp":1769166185583,"version":"3.49.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Th17 cells play a critical role in autoimmune diseases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Response gene to complement (RGC)-32 is a cell cycle regulator and a downstream target of TGF-\u03b2 that mediates its profibrotic activity. In this study, we report that RGC-32 is preferentially upregulated during Th17 cell differentiation. RGC-32\u2212\/\u2212 mice have normal Th1, Th2, and regulatory T cell differentiation but show defective Th17 differentiation in vitro. The impaired Th17 differentiation is associated with defects in IFN regulatory factor 4, B cell\u2013activating transcription factor, retinoic acid\u2013related orphan receptor \u03b3t, and SMAD2 activation. In vivo, RGC-32\u2212\/\u2212 mice display an attenuated experimental autoimmune encephalomyelitis phenotype accompanied by decreased CNS inflammation and reduced frequency of IL-17\u2013 and GM-CSF\u2013producing CD4+ T cells. Collectively, our results identify RGC-32 as a novel regulator of Th17 cell differentiation in vitro and in vivo and suggest that RGC-32 is a potential therapeutic target in multiple sclerosis and other Th17-mediated autoimmune diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1602158","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:40:14Z","timestamp":1490834414000},"page":"3869-3877","source":"Crossref","is-referenced-by-count":15,"title":["RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis"],"prefix":"10.1093","volume":"198","author":[{"given":"Violeta","family":"Rus","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Maryland School of Medicine , Baltimore, MD 21201"},{"name":"Research Service, Veteran Affairs Medical Center , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Maryland School of Medicine , Baltimore, MD 21201"},{"name":"Research Service, Veteran Affairs Medical Center , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2674-3278","authenticated-orcid":false,"given":"Alexandru","family":"Tatomir","sequence":"additional","affiliation":[{"name":"Research Service, Veteran Affairs Medical Center , Baltimore, MD 21201"},{"name":"Department of Neurology, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason R","family":"Lees","sequence":"additional","affiliation":[{"name":"Department of Medicine, Uniformed Services University of the Health Sciences , Bethesda, MD 20814"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-3594","authenticated-orcid":false,"given":"Armugam P","family":"Mekala","sequence":"additional","affiliation":[{"name":"Research Service, Veteran Affairs Medical Center , Baltimore, MD 21201"},{"name":"Department of Neurology, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dallas","family":"Boodhoo","sequence":"additional","affiliation":[{"name":"Research Service, Veteran Affairs Medical Center , Baltimore, MD 21201"},{"name":"Department of Neurology, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosmin A","family":"Tegla","sequence":"additional","affiliation":[{"name":"Research Service, Veteran Affairs Medical Center , Baltimore, MD 21201"},{"name":"Department of Neurology, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina G","family":"Luzina","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Maryland School of Medicine , Baltimore, MD 21201"},{"name":"Research Service, Veteran Affairs Medical Center , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A","family":"Antony","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia D","family":"Cudrici","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tudor C","family":"Badea","sequence":"additional","affiliation":[{"name":"Retinal Circuit Development and Genetics Unit, Neurobiology Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horea G","family":"Rus","sequence":"additional","affiliation":[{"name":"Research Service, Veteran Affairs Medical Center , Baltimore, MD 21201"},{"name":"Department of Neurology, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"2025030615140793000_r1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.yexmp.2008.12.005","article-title":"Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells","volume":"86","author":"Fosbrink","year":"2009","journal-title":"Exp. 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