{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:49:40Z","timestamp":1792093780554,"version":"4.4.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":2743,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rho family GTPases regulate diverse cellular events, such as cell motility, polarity, and vesicle traffic. Although a wealth of data exists on the canonical Rho GTPases RhoA, Rac1, and Cdc42, several other family members remain poorly studied. In B cells, we recently demonstrated a critical role for Cdc42 in plasma cell differentiation. In this study, we focus on a close homolog of Cdc42, TC10 (also known as RhoQ), and investigate its physiological role in B cells. By generating a TC10-deficient mouse model, we show that despite reduced total B cell numbers, B cell development in these mice occurs normally through distinct developmental stages. Upon immunization, IgM levels were reduced and, upon viral infection, germinal center responses were defective in TC10-deficient mice. BCR signaling was mildly affected, whereas cell migration remained normal in TC10-deficient B cells. Furthermore, by generating a TC10\/Cdc42 double knockout mouse model, we found that TC10 can compensate for the lack of Cdc42 in TLR-induced cell activation and proliferation, so the two proteins play partly redundant roles. Taken together, by combining in vivo and in vitro analysis using TC10-deficient mice, we define the poorly studied Rho GTPase TC10 as an immunomodulatory molecule playing a role in physiological B cell responses.<\/jats:p>","DOI":"10.4049\/jimmunol.1602167","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T20:25:35Z","timestamp":1501100735000},"page":"1682-1695","source":"Crossref","is-referenced-by-count":24,"title":["The Small Rho GTPase TC10 Modulates B Cell Immune Responses"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0686-2608","authenticated-orcid":false,"given":"Marianne","family":"Burbage","sequence":"first","affiliation":[{"name":"Lymphocyte Interaction Laboratory, Francis Crick Institute , London NW1 1AT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina J","family":"Keppler","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory, Francis Crick Institute , London NW1 1AT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9877-7317","authenticated-orcid":false,"given":"Beatriz","family":"Montaner","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory, Francis Crick Institute , London NW1 1AT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-0686","authenticated-orcid":false,"given":"Pieta K","family":"Mattila","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory, Francis Crick Institute , London NW1 1AT,","place":["United Kingdom"]},{"name":"Institute of Biomedicine, Unit of Pathology and MediCity Research Laboratories, University of Turku , BioCity, 20520 Turku,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1130-9463","authenticated-orcid":false,"given":"Facundo D","family":"Batista","sequence":"additional","affiliation":[{"name":"Lymphocyte Interaction Laboratory, Francis Crick Institute , London NW1 1AT,","place":["United Kingdom"]},{"name":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,1]]},"reference":[{"key":"2025030614272861700_r1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nri2454","article-title":"The who, how and where of antigen presentation to B cells","volume":"9","author":"Batista","year":"2009","journal-title":"Nat. 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