{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:03:02Z","timestamp":1770984182748,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Zika virus (ZIKV) has become a serious public health concern because of its link to brain damage in developing human fetuses. Recombinant vesicular stomatitis virus (rVSV) was shown to be a highly effective and safe vector for the delivery of foreign immunogens for vaccine purposes. In this study, we generated rVSVs (wild-type and attenuated VSV with mutated matrix protein [VSVm] versions) that express either the full length ZIKV envelope protein (ZENV) alone or include the ZENV precursor to the membrane protein upstream of the envelope protein, and our rVSV-ZIKV constructs showed efficient immunogenicity in murine models. We also demonstrated maternal protective immunity in challenged newborn mice born to female mice vaccinated with VSVm-ZENV containing the transmembrane domain. Our data indicate that rVSVm may be a suitable strategy for the design of effective vaccines against ZIKV.<\/jats:p>","DOI":"10.4049\/jimmunol.1602180","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:35:45Z","timestamp":1489451745000},"page":"3023-3028","source":"Crossref","is-referenced-by-count":46,"title":["Cutting Edge: Innate Immune Augmenting Vesicular Stomatitis Virus Expressing Zika Virus Proteins Confers Protective Immunity"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5654-7935","authenticated-orcid":false,"given":"Dillon","family":"Betancourt","sequence":"first","affiliation":[{"name":"Department of Cell Biology, University of Miami Miller School of Medicine , Miami, FL 33136"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina M G P","family":"de Queiroz","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Miami Miller School of Medicine , Miami, FL 33136"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianli","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Miami Miller School of Medicine , Miami, FL 33136"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeonghyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Miami Miller School of Medicine , Miami, FL 33136"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen N","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Miami Miller School of Medicine , Miami, FL 33136"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,4,15]]},"reference":[{"key":"2025030615090407600_r1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.antiviral.2016.03.010","article-title":"Zika virus: history, emergence, biology, and prospects for control","volume":"130","author":"Weaver","year":"2016","journal-title":"Antiviral Res."},{"key":"2025030615090407600_r2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/cid\/ciw210","article-title":"Zika virus: implications for public health","volume":"63","author":"Focosi","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"2025030615090407600_r3","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika virus and birth defects--reviewing the evidence for causality","volume":"374","author":"Rasmussen","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2025030615090407600_r4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3201\/eid2102.141363","article-title":"Potential sexual transmission of Zika virus","volume":"21","author":"Musso","year":"2015","journal-title":"Emerg. Infect. 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Virol."},{"key":"2025030615090407600_r11","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.vaccine.2008.11.087","article-title":"Recombinant vesicular stomatitis virus-based West Nile vaccine elicits strong humoral and cellular immune responses and protects mice against lethal challenge with the virulent West Nile virus strain LSU-AR01","volume":"27","author":"Iyer","year":"2009","journal-title":"Vaccine"},{"key":"2025030615090407600_r12","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1128\/JVI.76.2.895-904.2002","article-title":"Genetically engineered vesicular stomatitis virus in gene therapy: application for treatment of malignant disease","volume":"76","author":"Fernandez","year":"2002","journal-title":"J. Virol."},{"key":"2025030615090407600_r13","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.1128\/JVI.76.15.7642-7650.2002","article-title":"Adding genes to the RNA genome of vesicular stomatitis virus: positional effects on stability of expression","volume":"76","author":"Wertz","year":"2002","journal-title":"J. Virol."},{"key":"2025030615090407600_r14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/15216540050212169","article-title":"Vesicular stomatitis virus (VSV) therapy of tumors","volume":"50","author":"Balachandran","year":"2000","journal-title":"IUBMB Life"},{"key":"2025030615090407600_r15","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1128\/JVI.77.16.8843-8856.2003","article-title":"Development of recombinant vesicular stomatitis viruses that exploit defects in host defense to augment specific oncolytic activity","volume":"77","author":"Obuchi","year":"2003","journal-title":"J. Virol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/198\/8\/3023\/61449082\/1602180.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/198\/8\/3023\/61449082\/1602180.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T17:23:11Z","timestamp":1741281791000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/198\/8\/3023\/7954894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,4,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1602180","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,4]]},"published":{"date-parts":[[2017,4]]}}}