{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:56:23Z","timestamp":1778730983538,"version":"3.51.4"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To understand the pathogenesis of organ-specific autoimmune disease requires an appreciation of how the T cell-mediated inflammation is targeted, and how the organ function is compromised. In this study, autoantibody was documented to influence both of these parameters by modulating the distribution of T cell-mediated inflammation. The murine autoimmune ovarian disease is induced by immunization with the ZP3330\u2013342 peptide of the ovarian zona pellucida 3 glycoprotein, ZP3. Passively transferred or actively induced Ab to ZP3335\u2013342 bound to the zona pellucida in the functional and degenerative ovarian follicles, and the ovaries remained histologically normal. Transfer of ZP3330\u2013342 peptide-specific T cells targeted the degenerative follicles and spared the functional follicles, and the resultant interstitial oophoritis was associated with unimpaired ovarian function. Unexpectedly, the coexistence of ZP3330\u2013342 peptide-specific T cells and zona-bound autoantibody led to a dramatic translocation of the ovarian inflammation to the growing and mature ovarian follicles, with destruction of the ovarian functional unit. Ab retargeted both Th1-induced mononuclear inflammation and Th2-induced eosinophilic inflammation, and retargeting was induced by murine and rat polyclonal Abs to multiple distinct native B cell determinants of the zona pellucida. Therefore, by reacting with the native determinants in tissue Ag, Ab alters the distribution of T cell-mediated inflammation, and results in destruction of the functional units of the target organ. We propose that this is a clinically important and previously unappreciated element of Ab action in autoimmune disease.<\/jats:p>","DOI":"10.4049\/jimmunol.164.10.5251","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T22:30:08Z","timestamp":1398119408000},"page":"5251-5257","source":"Crossref","is-referenced-by-count":37,"title":["Retargeting T Cell-Mediated Inflammation: A New Perspective on Autoantibody Action"],"prefix":"10.1093","volume":"164","author":[{"given":"Ya-Huan","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Virginia School of Medicine , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan-Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Virginia School of Medicine , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Agersborg","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Virginia School of Medicine , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Alard","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Virginia School of Medicine , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth S K","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Virginia School of Medicine , Charlottesville, VA 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,5,15]]},"reference":[{"key":"2026020214021254700_R1","first-page":"197","volume-title":"J. Neurol. Sci.","year":"1985"},{"key":"2026020214021254700_R2","first-page":"260","volume-title":"Nature","year":"1991"},{"key":"2026020214021254700_R3","first-page":"635","volume-title":"Biol. Reprod.","year":"1999"},{"key":"2026020214021254700_R4","first-page":"1185","volume-title":"Science","year":"1995"},{"key":"2026020214021254700_R5","first-page":"75","volume-title":"Curr. Eye Res.","year":"1992"},{"key":"2026020214021254700_R6","first-page":"4136","volume-title":"J. Immunol.","year":"1993"},{"key":"2026020214021254700_R7","first-page":"1851","volume-title":"J. Clin. Invest.","year":"1996"},{"key":"2026020214021254700_R8","first-page":"597","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020214021254700_R9","first-page":"752","volume-title":"J. Immunol.","year":"1987"},{"key":"2026020214021254700_R10","first-page":"89","volume-title":"Brain Pathol.","year":"1991"},{"key":"2026020214021254700_R11","first-page":"25","volume-title":"Curr. Eye Res.","year":"1992"},{"key":"2026020214021254700_R12","first-page":"3667","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020214021254700_R13","first-page":"131","volume-title":"J. Neuroimmunol.","year":"1998"},{"key":"2026020214021254700_R14","first-page":"28","volume-title":"J. Clin. Invest.","year":"1992"},{"key":"2026020214021254700_R15","first-page":"169","volume-title":"J. Immunol. Methods","year":"1986"},{"key":"2026020214021254700_R16","first-page":"5790","volume-title":"J. Immunol.","year":"1993"},{"key":"2026020214021254700_R17","first-page":"2715","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020214021254700_R18","first-page":"900","volume-title":"Biol. Reprod.","year":"1999"},{"key":"2026020214021254700_R19","first-page":"801","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020214021254700_R20","first-page":"3535","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020214021254700_R21","first-page":"935","volume-title":"Science","year":"1989"},{"key":"2026020214021254700_R22","first-page":"349","volume-title":"Annu. Rev. Physiol.","year":"1997"},{"key":"2026020214021254700_R23","first-page":"323","volume-title":"Am. J. Reprod. Immunol.","year":"1995"},{"key":"2026020214021254700_R24"},{"key":"2026020214021254700_R25","first-page":"3428","volume-title":"J. Immunol.","year":"1986"},{"key":"2026020214021254700_R26","first-page":"2625","volume-title":"J. Immunol.","year":"1988"},{"key":"2026020214021254700_R27","first-page":"1","volume-title":"J. Neuroimmunol.","year":"1992"},{"key":"2026020214021254700_R28","first-page":"375","volume-title":"J. Neurosci. Res.","year":"1987"},{"key":"2026020214021254700_R29","first-page":"165","volume-title":"Experimental Allergic Encephalomyelitis: A Useful Model for Multiple Sclerosis","year":"1984"},{"key":"2026020214021254700_R30","first-page":"17","volume-title":"J. Neuroimmunol.","year":"1995"},{"key":"2026020214021254700_R31","first-page":"40","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020214021254700_R32","first-page":"169","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026020214021254700_R33","first-page":"219","volume-title":"J. Neuroimmunol.","year":"1992"},{"key":"2026020214021254700_R34","first-page":"4016","volume-title":"J. Immunol.","year":"1987"},{"key":"2026020214021254700_R35","first-page":"8955","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1995"},{"key":"2026020214021254700_R36","first-page":"451","volume-title":"Immunity","year":"1999"},{"key":"2026020214021254700_R37","first-page":"642","volume-title":"Kidney Int.","year":"1987"},{"key":"2026020214021254700_R38","first-page":"938","volume-title":"Kidney Int.","year":"1989"},{"key":"2026020214021254700_R39","first-page":"2049","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020214021254700_R40","first-page":"1159","volume-title":"Int. Immunol.","year":"1997"},{"key":"2026020214021254700_R41","first-page":"743","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020214021254700_R42","first-page":"85","volume-title":"Hum. Reprod.","year":"1998"},{"key":"2026020214021254700_R43","first-page":"3145","volume-title":"J. Immunol.","year":"1989"},{"key":"2026020214021254700_R44","first-page":"121","volume-title":"Curr. Opin. Immunol.","year":"1997"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/164\/10\/5251\/62144338\/5251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/164\/10\/5251\/62144338\/5251.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:02:28Z","timestamp":1770058948000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/164\/10\/5251\/8039896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":44,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2000,5,15]]},"published-print":{"date-parts":[[2000,5,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.164.10.5251","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,5]]},"published":{"date-parts":[[2000,5]]}}}