{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:56:03Z","timestamp":1791294963806,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thymocyte development is a tightly regulated process. CD4+CD8+ double-positive (DP) immature thymocytes exhibit distinct phenotypic features from mature T cells; they express only 10% of surface TCR that are found on mature T cells and do not proliferate and produce IL-2 in response to stimulation. In this report we show that transgenic expression of the orphan nuclear receptor ROR\u03b3t in mature T cells down-regulates their surface TCR expression. The ROR\u03b3t transgene inhibits IL-2 production by mature T cells, and this inhibition may be partially due to the inhibitory effect of ROR\u03b3t on c-Rel transcription. Furthermore, ectopic expression of ROR\u03b3t inhibits the proliferation of mature and immature T cells. These results, together with its predominant expression in DP thymocytes, suggest that ROR\u03b3t controls these distinct phenotypic features of DP thymocytes. Our data suggest that down-regulation of ROR\u03b3t expression in thymocytes is essential for their maturation.<\/jats:p>","DOI":"10.4049\/jimmunol.164.11.5668","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:57:35Z","timestamp":1398027455000},"page":"5668-5674","source":"Crossref","is-referenced-by-count":63,"title":["Down-Regulation of the Orphan Nuclear Receptor ROR\u03b3t Is Essential for T Lymphocyte Maturation"],"prefix":"10.1093","volume":"164","author":[{"given":"You-Wen","family":"He","sequence":"first","affiliation":[{"name":"Department of Immunology and Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Beers","sequence":"additional","affiliation":[{"name":"Department of Immunology and Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L","family":"Deftos","sequence":"additional","affiliation":[{"name":"Department of Immunology and Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan W","family":"Ojala","sequence":"additional","affiliation":[{"name":"Department of Immunology and Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Forbush","sequence":"additional","affiliation":[{"name":"Department of Immunology and Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Bevan","sequence":"additional","affiliation":[{"name":"Department of Immunology and Howard Hughes Medical Institute, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,6,1]]},"reference":[{"key":"2026020214031640700_R1","first-page":"547","volume-title":"Immunol. 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