{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:28:27Z","timestamp":1790166507755,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Even in the absence of an appropriate model or direct evidence, T cells have been hypothesized to exacerbate the manifestations of Lyme disease. To define definitely the role of T cells in Lyme disease, the course of disease in immunocompetent and B cell-deficient mice was compared. By 8 wk postinoculation, immunocompetent mice resolved both carditis and arthritis, whereas foci of myocarditis and severe destructive arthritis characterized disease of B cell-deficient mice. Cell transfer experiments using infected B6-Rag1 knock out mice demonstrated that: 1) innate immunity mediated the initial sequelae of infection, 2) transferring both naive T cells and B cells induced resolution of carditis and arthritis, 3) infected mice reconstituted with T cells developed myocarditis and severe destructive arthritis, and 4) CD4+ T cells were responsible for the observed immune-mediated pathology. These data demonstrate directly the deleterious effect of T cells in Lyme disease.<\/jats:p>","DOI":"10.4049\/jimmunol.164.12.6096","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:59:29Z","timestamp":1398031169000},"page":"6096-6099","source":"Crossref","is-referenced-by-count":63,"title":["Cutting Edge: T Cell-Mediated Pathology in Murine Lyme Borreliosis"],"prefix":"10.1093","volume":"164","author":[{"given":"Maureen D","family":"McKisic","sequence":"first","affiliation":[{"name":"Center for Comparative Medicine, University of California , Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L","family":"Redmond","sequence":"additional","affiliation":[{"name":"Department Of Immunology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W","family":"Barthold","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine, University of California , Davis, CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,6,15]]},"reference":[{"key":"2026020214034608700_R1"},{"key":"2026020214034608700_R2","first-page":"399","volume-title":"Rheum. Dis. Clin. North Am.","year":"1993"},{"key":"2026020214034608700_R3","first-page":"22","volume-title":"J. Spirochetal Tick-borne Dis.","year":"1996"},{"key":"2026020214034608700_R4","first-page":"605","volume-title":"Am. J. Trop. Med. Hyg.","year":"1992"},{"key":"2026020214034608700_R5","first-page":"811","volume-title":"Am. J. Pathol.","year":"1990"},{"key":"2026020214034608700_R6","first-page":"150","volume-title":"J. Infect. Dis.","year":"1989"},{"key":"2026020214034608700_R7","first-page":"73","volume-title":"Eur. Heart J.","year":"1991"},{"key":"2026020214034608700_R8","first-page":"26","volume-title":"Am. J. Pathol.","year":"1985"},{"key":"2026020214034608700_R9","first-page":"1621","volume-title":"Arthritis Rheum.","year":"1993"},{"key":"2026020214034608700_R10","first-page":"146","volume-title":"Lancet","year":"1993"},{"key":"2026020214034608700_R11","first-page":"568","volume-title":"J. Infect. Dis.","year":"1991"},{"key":"2026020214034608700_R12","first-page":"1109","volume-title":"Infect. Immun.","year":"1992"},{"key":"2026020214034608700_R13","first-page":"1968","volume-title":"J. Immunol.","year":"1991"},{"key":"2026020214034608700_R14","first-page":"218","volume-title":"J. Immunol.","year":"1992"},{"key":"2026020214034608700_R15","first-page":"1022","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020214034608700_R16","first-page":"1770","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020214034608700_R17","first-page":"1251","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020214034608700_R18","first-page":"69","volume-title":"Arthritis Rheum.","year":"1997"},{"key":"2026020214034608700_R19"},{"key":"2026020214034608700_R20","first-page":"2020","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020214034608700_R21","first-page":"1028","volume-title":"J. Clin. Invest.","year":"1996"},{"key":"2026020214034608700_R22","first-page":"1","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020214034608700_R23","first-page":"951","volume-title":"Am. J. Pathol.","year":"1993"},{"key":"2026020214034608700_R24","first-page":"521","volume-title":"Yale J. Biol. Med.","year":"1984"},{"key":"2026020214034608700_R25","first-page":"249","volume-title":"Am. J. Trop. Med. Hyg.","year":"1992"},{"key":"2026020214034608700_R26","first-page":"57","volume-title":"Lab. Invest.","year":"1996"},{"key":"2026020214034608700_R27","first-page":"133","volume-title":"J. Infect. Dis.","year":"1990"},{"key":"2026020214034608700_R28","first-page":"69","volume-title":"Adv. Int. Med.","year":"1995"},{"key":"2026020214034608700_R29","first-page":"1436","volume-title":"Transplantation","year":"1998"},{"key":"2026020214034608700_R30","first-page":"38","volume-title":"J. Immunol.","year":"1993"},{"key":"2026020214034608700_R31","first-page":"1905","volume-title":"J. Immunol.","year":"1992"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/164\/12\/6096\/62154642\/6096.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/164\/12\/6096\/62154642\/6096.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:04:54Z","timestamp":1770059094000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/164\/12\/6096\/8040914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":31,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2000,6,15]]},"published-print":{"date-parts":[[2000,6,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.164.12.6096","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,6]]},"published":{"date-parts":[[2000,6]]}}}