{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:49:02Z","timestamp":1773272942318,"version":"3.50.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic rejection represents a major cause of long-term kidney graft loss. T cells that are predominant in long-term rejected kidney allografts (35 \u00b1 10% of area infiltrate) may thus be instrumental in this phenomenom, which is likely to be dependant on the indirect pathway of allorecognition only. We have analyzed the variations in T cell repertoire usage of the V\u03b2 chain at the complementary determining region 3 (CDR3) level in 18 human kidney grafts lost due to chronic rejection. We observed a strongly biased intragraft TCR V\u03b2 usage for the majority of V\u03b2 families and also a very high percentage (55%) of V\u03b2 families exhibiting common and oligoclonal V\u03b2-C\u03b2 rearrangements in the grafts of patients with chronic rejection associated with superimposed histologically acute lesions. Furthermore, V\u03b28 and V\u03b223 families exhibited common and oligoclonal V\u03b2-J\u03b2 rearrangements in 4 of 18 patients (22%). Several CDR3 amino acid sequences were found for the common and oligoclonal V\u03b28-J\u03b21.4 rearrangement. Quantitative PCR showed that biased V\u03b2 transcripts were also overexpressed in chronically rejected kidneys with superimposed acute lesions. In contrast, T lymphocytes infiltrating rejected allografts with chronic rejection only showed an unaltered Gaussian-type CDR3 length distribution. This pattern suggests that late graft failure associated with histological lesions restricted to Banff-defined chronic rejection does not involve T cell-mediated injury. Thus, our observation suggests that a limited number of determinants stimulates the recipient immune system in long-term allograft failure. The possibility of a local response against viral or parenchymatous cell-derived determinants is discussed.<\/jats:p>","DOI":"10.4049\/jimmunol.164.3.1553","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T18:48:20Z","timestamp":1398106100000},"page":"1553-1563","source":"Crossref","is-referenced-by-count":50,"title":["Highly Altered V\u03b2 Repertoire of T Cells Infiltrating Long-Term Rejected Kidney Allografts"],"prefix":"10.1093","volume":"164","author":[{"given":"Katia","family":"Gagne","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 437, \u201cImmunointervention dans les Allo et Xe\u0301notransplantations\u201d and Institut de Transplantation et de Recherche en Transplantation, Centre Hospitalier Universitaire Hotel Dieu , Nantes ,","place":["France"]},{"name":"Etablissement de Transfusion Sanguine , Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Brouard","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 437, \u201cImmunointervention dans les Allo et Xe\u0301notransplantations\u201d and Institut de Transplantation et de Recherche en Transplantation, Centre Hospitalier Universitaire Hotel Dieu , Nantes ,","place":["France"]},{"name":"Harvard Medical School, Beth Israel, Deaconess Medical Center , Boston, MA 02215"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Giral","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 437, \u201cImmunointervention dans les Allo et Xe\u0301notransplantations\u201d and Institut de Transplantation et de Recherche en Transplantation, Centre Hospitalier Universitaire Hotel Dieu , Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Sebille","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 437, \u201cImmunointervention dans les Allo et Xe\u0301notransplantations\u201d and Institut de Transplantation et de Recherche en Transplantation, Centre Hospitalier Universitaire Hotel Dieu , Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Moreau","sequence":"additional","affiliation":[{"name":"Service d\u2019Anatomopathologie, Centre Hospitalier Universitaire Hotel Dieu , Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Guillet","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 437, \u201cImmunointervention dans les Allo et Xe\u0301notransplantations\u201d and Institut de Transplantation et de Recherche en Transplantation, Centre Hospitalier Universitaire Hotel Dieu , Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Denis","family":"Bignon","sequence":"additional","affiliation":[{"name":"Etablissement de Transfusion Sanguine , Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthe-Marie","family":"Imbert","sequence":"additional","affiliation":[{"name":"Service de Virologie, Institut de Biologie , Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Cristina","family":"Cuturi","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 437, \u201cImmunointervention dans les Allo et Xe\u0301notransplantations\u201d and Institut de Transplantation et de Recherche en Transplantation, Centre Hospitalier Universitaire Hotel Dieu , Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Soulillou","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 437, \u201cImmunointervention dans les Allo et Xe\u0301notransplantations\u201d and Institut de Transplantation et de Recherche en Transplantation, Centre Hospitalier Universitaire Hotel Dieu , Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,2,1]]},"reference":[{"key":"2026020213135392600_R1","first-page":"972","volume-title":"Kidney. 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