{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:09:31Z","timestamp":1791036571570,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infection of mice with Salmonella typhimurium gives rise to a disease similar to human typhoid fever caused by S. typhi. Since S. typhimurium is a facultative intracellular bacterium, the requirement of B cells in the immune response against S. typhimurium is a longstanding matter of debate. By infecting mice on a susceptible background and deficient in B cells (Ig\u03bc\u2212\/\u2212 mice) with different strains of S. typhimurium, we could for the first time formally clarify the role of B cells in the response against S. typhimurium. Compared with Ig\u03bc+\/+ mice, LD50 values in Ig\u03bc\u2212\/\u2212 mice were reduced during primary, and particularly secondary, oral infection with virulent S. typhimurium. After systemic infection, Ig\u03bc\u2212\/\u2212 mice cleared attenuated aroA\u2212 \u00a0S. typhimurium, but vaccine-induced protection against systemic infection with virulent S. typhimurium involved both B cell-dependent and -independent effector mechanisms. Thus, B cell-mediated immunity plays a distinct role in control of S. typhimurium in susceptible mice.<\/jats:p>","DOI":"10.4049\/jimmunol.164.4.1648","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T14:44:52Z","timestamp":1398177892000},"page":"1648-1652","source":"Crossref","is-referenced-by-count":117,"title":["Cutting Edge: Role of B Lymphocytes in Protective Immunity Against\n                    <i>Salmonella typhimurium<\/i>\n                    Infection"],"prefix":"10.1093","volume":"164","author":[{"given":"Hans-Willi","family":"Mittru\u0308cker","sequence":"first","affiliation":[{"name":"Department of Immunology, Max Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ba\u0308rbel","family":"Raupach","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Ko\u0308hler","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H E","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max Planck Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,2,15]]},"reference":[{"key":"2026020213174423100_R1","first-page":"143","volume-title":"Host Response to Intracellular Pathogens","year":"1997"},{"key":"2026020213174423100_R2","first-page":"51","volume-title":"Intracellular Bacterial Vaccine Vectors","year":"1999"},{"key":"2026020213174423100_R3","first-page":"655","volume-title":"J. 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