{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:07:12Z","timestamp":1791079632938,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tissue eosinophilia prevention represents one of the primary targets to new anti-allergic therapies. As lipoxin A4 (LXA4) and aspirin-triggered 15-epi-LXA4 (ATL) are emerging as endogenous \u201cstop signals\u201d produced in distinct pathologies including some eosinophil-related pulmonary disorders, we evaluated the impact of in situ LXA4\/ATL metabolically stable analogues on allergen-induced eosinophilic pleurisy in sensitized rats. LXA4\/ATL analogues dramatically blocked allergic pleural eosinophil influx, while concurrently increasing circulating eosinophilia, inhibiting the earlier edema and neutrophilia associated with allergic reaction. The mechanisms underlying this LXA4\/ATL-driven allergic eosinophilia blockade was independent of mast cell degranulation and involved LXA4\/ATL inhibition of both IL-5 and eotaxin generation, as well as platelet activating factor action. These findings reveal LXA4\/ATL as a novel class of endogenous anti-allergic mediators, capable of preventing local eosinophilia.<\/jats:p>","DOI":"10.4049\/jimmunol.164.5.2267","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T19:48:34Z","timestamp":1398109714000},"page":"2267-2271","source":"Crossref","is-referenced-by-count":86,"title":["Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking"],"prefix":"10.1093","volume":"164","author":[{"given":"Christianne","family":"Bandeira-Melo","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacodynamics, Oswaldo Cruz Institute, Fundac\u0327ao Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia T","family":"Bozza","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacodynamics, Oswaldo Cruz Institute, Fundac\u0327ao Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno L","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacodynamics, Oswaldo Cruz Institute, Fundac\u0327ao Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato S B","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacodynamics, Oswaldo Cruz Institute, Fundac\u0327ao Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Jose","sequence":"additional","affiliation":[{"name":"Leucocyte Biology, Biomedical Sciences Division, Imperial College School of Medicine , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacodynamics, Oswaldo Cruz Institute, Fundac\u0327ao Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N","family":"Serhan","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2026020213161794900_R1","first-page":"85","volume-title":"Annu. 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