{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:35:23Z","timestamp":1779244523086,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To clarify the pathogenesis of human T lymphotropic virus type I (HTLV-I)-associated Sjo\u0308gren\u2019s syndrome (SS), the TCR V\u03b2 gene usage by the infiltrating lymphocytes in the target organ was examined. The V\u03b2 families predominantly used in the labial salivary gland (LSG) from the HTLV-I-seropositive (HTLV-I+) SS patients were more restricted than those from the HTLV-I-seronegative (idiopathic) SS patients, and were commonly V\u03b25.2, V\u03b26, and V\u03b27. The single-strand conformation polymorphism analysis revealed that T cell clonotypes with V\u03b25.2, V\u03b26, and V\u03b27 accumulate in the LSG from the HTLV-I+ and idiopathic SS patients. Among junctional sequences of the most dominant V\u03b27 transcripts, the conserved amino acid motif (QDXG: X is any amino acid) was found in six of the five HTLV-I+ SS patients and was also detected in two of the five idiopathic SS patients. Using the probes specific to the motif, the V\u03b27 transcripts with the motif were detected in the LSG from all of the seven HTLV-I+ and five of the six idiopathic SS patients, but not from eight healthy subjects. The V\u03b27 transcripts with this motif were also detected in the HTLV-I-infected T cell lines obtained from the LSG of an HTLV-I+ SS patient. The accumulation of HTLV-I-infected T cells expressing TCR with the conserved motif was thus indicated. These T cells were commonly present in patients with idiopathic SS and are strongly suggested to most likely be involved in the pathogenesis of both HTLV-I-associated and idiopathic SS.<\/jats:p>","DOI":"10.4049\/jimmunol.164.5.2823","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T19:48:34Z","timestamp":1398109714000},"page":"2823-2831","source":"Crossref","is-referenced-by-count":33,"title":["Accumulation of Common T Cell Clonotypes in the Salivary Glands of Patients with Human T Lymphotropic Virus Type I-Associated and Idiopathic Sjo\u0308gren\u2019s Syndrome"],"prefix":"10.1093","volume":"164","author":[{"given":"Masanori","family":"Sasaki","sequence":"first","affiliation":[{"name":"Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiko","family":"Ezaki","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Beppu University Junior College , Beppu, Oita ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Kadena","sequence":"additional","affiliation":[{"name":"Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kishihara","sequence":"additional","affiliation":[{"name":"Department of Immunology, Medical Institute of Bioregulation, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kikuo","family":"Nomoto","sequence":"additional","affiliation":[{"name":"Department of Immunology, Medical Institute of Bioregulation, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanemitsu","family":"Shirasuna","sequence":"additional","affiliation":[{"name":"Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2026020213172119800_R1","first-page":"7415","volume-title":"Proc. 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