{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:11:26Z","timestamp":1790565086894,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Shigella is a diarrheal pathogen that causes disease through invasion of the large intestinal mucosa. The endotoxin of the invading bacterium may play a key role in the disease process by causing inflammation and tissue injury during infection. Earlier studies have shown that various animal species lacking functional CD14 were protected against endotoxin-mediated shock. Rabbits experimentally infected with Shigella were used to test the hypothesis that blockade of endotoxin-induced cell activation with anti-CD14 mAb would diminish inflammation and thus disease severity. Unexpectedly, we observed that the intestinal mucosa of anti-CD14-treated animals exhibited a 50-fold increase in bacterial invasion and more severe tissue injury compared with controls. Despite higher bacterial loads in treated animals, the numbers of polymorphonuclear leukocytes that were recruited to the infection site were similar to those in controls. Furthermore, the phagocytic cells of CD14-blocked animals produced IL-1 and TNF-\u03b1. Moreover, in vitro blockade of CD14 did not impede bactericidal activity. Thus, anti-CD14 treatment interfered with host defense mechanisms involved with removal\/eradication of Shigella.<\/jats:p>","DOI":"10.4049\/jimmunol.164.6.3214","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T16:28:33Z","timestamp":1398184113000},"page":"3214-3221","source":"Crossref","is-referenced-by-count":28,"title":["Blockade of CD14 Increases\n                    <i>Shigella-<\/i>\n                    Mediated Invasion and Tissue Destruction"],"prefix":"10.1093","volume":"164","author":[{"given":"Christine","family":"Wennera\u030as","sequence":"first","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 389, Institut Pasteur , Paris ,","place":["France"]},{"name":"Department of Medical Microbiology and Immunology, Go\u0308teborg University , Go\u0308teborg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Ave","sequence":"additional","affiliation":[{"name":"Unite\u0301 d\u2019Histopathologie, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Huerre","sequence":"additional","affiliation":[{"name":"Unite\u0301 d\u2019Histopathologie, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette","family":"Arondel","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 389, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Ulevitch","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Mathison","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Sansonetti","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 389, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,3,15]]},"reference":[{"key":"2026020213175475000_R1","volume-title":"Manual for the Treatment of Diarrhoea: For Use by Physicians and Other Senior Health Workers, 1990","year":"1990"},{"key":"2026020213175475000_R2","first-page":"611","volume-title":"J. Infect. Dis.","year":"1973"},{"key":"2026020213175475000_R3","first-page":"138","volume-title":"Emerging Infectious Dis.","year":"1995"},{"key":"2026020213175475000_R4","first-page":"25","volume-title":"Am. J. Pathol.","year":"1986"},{"key":"2026020213175475000_R5","first-page":"289","volume-title":"Infect. Immun.","year":"1995"},{"key":"2026020213175475000_R6","first-page":"1193","volume-title":"Nat. Med.","year":"1997"},{"key":"2026020213175475000_R7","first-page":"884","volume-title":"J. Clin. Invest.","year":"1995"},{"key":"2026020213175475000_R8","first-page":"1471","volume-title":"Infect. Immun.","year":"1999"},{"key":"2026020213175475000_R9","first-page":"1431","volume-title":"Science","year":"1990"},{"key":"2026020213175475000_R10","first-page":"4384","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020213175475000_R11","first-page":"5556","volume-title":"J. Immunol.","year":"1993"},{"key":"2026020213175475000_R12","first-page":"407","volume-title":"Immunity","year":"1996"},{"key":"2026020213175475000_R13","first-page":"2209","volume-title":"J. Clin. Invest.","year":"1992"},{"key":"2026020213175475000_R14","first-page":"340","volume-title":"Immunology","year":"1998"},{"key":"2026020213175475000_R15","first-page":"1533","volume-title":"J. Clin. Invest.","year":"1996"},{"key":"2026020213175475000_R16","first-page":"13875","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1998"},{"key":"2026020213175475000_R17","first-page":"2380","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1993"},{"key":"2026020213175475000_R18","first-page":"852","volume-title":"Infect. Immun.","year":"1982"},{"key":"2026020213175475000_R19","first-page":"1127","volume-title":"J. Histochem. Cytochem.","year":"1994"},{"key":"2026020213175475000_R20","first-page":"1345","volume-title":"Nature","year":"1957"},{"key":"2026020213175475000_R21","first-page":"2412","volume-title":"J. Appl. Physiol.","year":"1991"},{"key":"2026020213175475000_R22","first-page":"206","volume-title":"Clin. Exp. Immunol.","year":"1993"},{"key":"2026020213175475000_R23","first-page":"99","volume-title":"J. Immunol. Methods","year":"1986"},{"key":"2026020213175475000_R24","first-page":"225","volume-title":"J. Virol. Methods","year":"1992"},{"key":"2026020213175475000_R25","first-page":"1","volume-title":"J. Immunol. Methods","year":"1997"},{"key":"2026020213175475000_R26","first-page":"1665","volume-title":"J. Exp. Med.","year":"1992"},{"key":"2026020213175475000_R27","first-page":"2744","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1993"},{"key":"2026020213175475000_R28","first-page":"865","volume-title":"J. Infect. Dis.","year":"1992"},{"key":"2026020213175475000_R29","first-page":"509","volume-title":"Immunity","year":"1994"},{"key":"2026020213175475000_R30","first-page":"676","volume-title":"J. Clin. Invest.","year":"1995"},{"key":"2026020213175475000_R31","first-page":"2085","volume-title":"Science","year":"1998"},{"key":"2026020213175475000_R32","first-page":"615","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020213175475000_R33","first-page":"742","volume-title":"Nature","year":"1997"},{"key":"2026020213175475000_R34","first-page":"22378","volume-title":"J. Biol. Chem.","year":"1995"},{"key":"2026020213175475000_R35","first-page":"603","volume-title":"J. Clin. Invest.","year":"1995"},{"key":"2026020213175475000_R36","first-page":"1593","volume-title":"Gut","year":"1994"},{"key":"2026020213175475000_R37","first-page":"807","volume-title":"Life Sci.","year":"1992"},{"key":"2026020213175475000_R38","first-page":"3949","volume-title":"J. Immunol.","year":"1987"},{"key":"2026020213175475000_R39","first-page":"149","volume-title":"Scand. J. Immunol.","year":"1984"},{"key":"2026020213175475000_R40","first-page":"55","volume-title":"J. Clin. Invest.","year":"1995"},{"key":"2026020213175475000_R41","first-page":"1295","volume-title":"Infect. Immun.","year":"1992"},{"key":"2026020213175475000_R42","first-page":"88","volume-title":"Infect. Immun.","year":"1999"},{"key":"2026020213175475000_R43","first-page":"4480","volume-title":"Infect. Immun.","year":"1996"},{"key":"2026020213175475000_R44","first-page":"3501","volume-title":"Infect. Immun.","year":"1997"},{"key":"2026020213175475000_R45","first-page":"4119","volume-title":"J. Immunol.","year":"1996"},{"key":"2026020213175475000_R46","first-page":"786","volume-title":"J. Leukocyte Biol.","year":"1997"},{"key":"2026020213175475000_R47","first-page":"259","volume-title":"FEMS Microbiol. Lett.","year":"1997"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/164\/6\/3214\/62743165\/3214.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/164\/6\/3214\/62743165\/3214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:29:23Z","timestamp":1770056963000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/164\/6\/3214\/8039671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2000,3,15]]},"published-print":{"date-parts":[[2000,3,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.164.6.3214","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,3]]},"published":{"date-parts":[[2000,3]]}}}