{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:03:00Z","timestamp":1790172180947,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Both in vitro studies and experiments in mice suggest a key role for transcription factor NF-\u03baB as a mediator of mucosal inflammation. Experiments in vitro show that NF-\u03baB activation may be a critical event in the production of proinflammatory molecules in Helicobacter pylori-associated gastritis. This study examines the expression and activity of NF-\u03baB in situ in antral biopsies of 69 consecutive patients with immunohistochemical techniques. In the uninflamed stomach, NF-\u03baB was highly expressed and active in a subset of epithelial cells, which were identified as predominantly G cells. In accordance with this activity, G cells were shown to express high levels of the NF-\u03baB target cytokine TNF-\u03b1, a well-documented stimulator of gastrin production. In patients with H. pylori-associated gastritis, NF-\u03baB activity was markedly enhanced. Activation occurred preferentially in the epithelial cells. The number of cells showing activated NF-\u03baB correlated with the activity of gastritis, a measure of neutrophil influx, whereas no correlation was found with the chronicity of inflammation, a measure of the presence of mononuclear inflammatory cells. This correlation is direct evidence of the importance of NF-\u03baB-dependent signal transduction for neutrophil influx in H. pylori-associated gastritis.<\/jats:p>","DOI":"10.4049\/jimmunol.164.6.3353","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T16:28:33Z","timestamp":1398184113000},"page":"3353-3359","source":"Crossref","is-referenced-by-count":70,"title":["Expression and Activation of NF-\u03baB in the Antrum of the Human Stomach"],"prefix":"10.1093","volume":"164","author":[{"given":"Gijs R","family":"van den Brink","sequence":"first","affiliation":[{"name":"Department of Experimental Internal Medicine, Academic Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiebo J","family":"ten Kate","sequence":"additional","affiliation":[{"name":"Department of Pathology, Academic Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyriel Y","family":"Ponsioen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Academic Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike M","family":"Rive","sequence":"additional","affiliation":[{"name":"Department of Experimental Internal Medicine, Academic Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido N","family":"Tytgat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Academic Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander J H","family":"van Deventer","sequence":"additional","affiliation":[{"name":"Department of Experimental Internal Medicine, Academic Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maikel P","family":"Peppelenbosch","sequence":"additional","affiliation":[{"name":"Department of Experimental Internal Medicine, Academic Medical Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,3,15]]},"reference":[{"key":"2026020214022169600_R1","first-page":"315","volume-title":"Science","year":"1996"},{"key":"2026020214022169600_R2","first-page":"1066","volume-title":"N. 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