{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:06:08Z","timestamp":1774566368404,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The mechanism(s) controlling activation of naive B cells, their proliferation, Ag receptor affinity maturation, isotype switching, and their fate as memory or plasma cells is not fully elucidated. Here we show that between 24 and 60% of CD19+ cells in PBMC bind soluble CD14 (sCD14). Tonsillar B cells also bind sCD14, but preferentially the CD38\u2212ve\/low cells. Interaction of sCD14 with B cells resulted in higher levels of IgG1 and marked inhibition of IgE production by activated tonsillar B cells and Ag-stimulated PBMC. We found that sCD14 interfered with CD40 signaling in B cells, inhibited IL-6 production by activated B cells, and increased the kinetics and magnitude of CD40 ligand expression on T cells. Together with the previously reported effects on T cells, these findings define sCD14 as a novel soluble regulatory factor capable of modulating cellular and humoral immune responses by interacting directly with T and B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.164.7.3480","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:24:59Z","timestamp":1398032699000},"page":"3480-3486","source":"Crossref","is-referenced-by-count":44,"title":["Cutting Edge: Human B Cell Function Is Regulated by Interaction with Soluble CD14: Opposite Effects on IgG1 and IgE Production"],"prefix":"10.1093","volume":"164","author":[{"given":"Mauricio A","family":"Arias","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Wales, College of Medicine , Cardiff ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia E","family":"Rey Nores","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wales, College of Medicine , Cardiff ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalio","family":"Vita","sequence":"additional","affiliation":[{"name":"Sanofi-Synthelabo , Labe\u0300ge ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Stelter","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Transfusion Medicine, Ernst-Moritz-Arndt-University , Greifswald ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek K","family":"Borysiewicz","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wales, College of Medicine , Cardiff ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascual","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Sanofi-Synthelabo , Labe\u0300ge ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario O","family":"Labe\u0301ta","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wales, College of Medicine , Cardiff ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"2025032908444639200_R1","first-page":"53","volume-title":"Immunol. 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