{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:55:38Z","timestamp":1791118538154,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role of perforin, IFN-\u03b3, and TNF-\u03b1 in anti-tumor CD8 T cell immunity was examined in a new tumor model using a CD8 T cell epitope (GP33) derived from lymphocytic choriomeningitis virus as a tumor-associated Ag. In contrast with parental 3LL-A9 (A9) Lewis lung carcinoma cells that progressively grow in C57BL\/6 mice, s.c. injection of GP33-transfected A9GP33 tumor cells induced a protective GP33-specific CD8 T cell response that led to complete tumor cell elimination. Tumor regression was dependent on perforin, IFN-\u03b3, or TNF-\u03b1, because A9GP33 tumors developed in mice deficient in one of these genes. A9GP33 tumors arising in perforin- and IFN-\u03b3-deficient mice represented GP33 Ag-loss variants, demonstrating that GP33-specific CD8 T cells from these mice were able to exert an Ag selection pressure. In contrast, tumor cells growing in TNF-\u03b1 knock-out mice still expressed the tumor-associated GP33 peptide despite the presence of activated GP33-specific CD8 T cells. These findings provide evidence for a crucial role of TNF-\u03b1 in A9 tumor cell elimination by CD8 T cells in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.164.7.3645","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T22:24:59Z","timestamp":1398032699000},"page":"3645-3651","source":"Crossref","is-referenced-by-count":66,"title":["Crucial Role of TNF-\u03b1 in CD8 T Cell-Mediated Elimination of 3LL-A9 Lewis Lung Carcinoma Cells In Vivo"],"prefix":"10.1093","volume":"164","author":[{"given":"Armelle","family":"Pre\u0301vost-Blondel","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Roth","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia M","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Cell Genix Technologie Transfer, GmbH , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"2025032908441531700_R1","first-page":"343","volume-title":"Immunity","year":"1994"},{"key":"2025032908441531700_R2","first-page":"4450","volume-title":"J. 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