{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:24:22Z","timestamp":1790857462021,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>By using mice genomically lacking IFN-\u03b3R, IL-12, perforin, and recombination-activating gene-1 (RAG-1), we analyzed the regulation and importance of IFN-\u03b3 in the control of infection with Chlamydia \u00a0pneumoniae. IL-12 participates in resistance of mice to C. pneumoniae, probably by regulating the protective levels of IFN-\u03b3 mRNA. In turn, IFN-\u03b3 is necessary for the increased IL-12p40 mRNA accumulation that occurs in lungs during infection with C. pneumoniae, suggesting a positive feedback regulation between these two cytokines. In experiments including RAG-1\u2212\/\u2212\/IFN-\u03b3R\u2212\/\u2212 mice we showed that IFN-\u03b3 produced by innate cells controls the bacterial load and is necessary for the increased accumulation of transcripts for enzymes controlling high output NO release (inducible NO synthase), superoxide production (gp-91 NADPH oxidase), and catalyzis of tryptophan (indoleamine 2,3-dioxygenase (IDO)), mechanisms probably related to bacterial killing. Adaptive immune reponses diminish the levels of IFN-\u03b3 and IL-12 mRNA and thereby the levels of inducible NO synthase, IDO, and gp91 NADPH oxidase trancripts. By using RAG-1\u2212\/\u2212\/perforin\u2212\/\u2212 mice, we excluded the overt participation of NK cell cytotoxicity in the control of C. pneumoniae. However, NK cells and probably other innate immune cells release IFN-\u03b3 during the bacterial infection.<\/jats:p>","DOI":"10.4049\/jimmunol.164.9.4812","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T22:34:50Z","timestamp":1398119690000},"page":"4812-4818","source":"Crossref","is-referenced-by-count":102,"title":["Regulation and Role of IFN-\u03b3 in the Innate Resistance to Infection with\n                    <i>Chlamydia<\/i>\n                    \u00a0\n                    <i>pneumoniae<\/i>"],"prefix":"10.1093","volume":"164","author":[{"given":"Marti\u0301n E","family":"Rottenberg","sequence":"first","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gigliotti Rothfuchs","sequence":"additional","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulceaydee","family":"Gigliotti","sequence":"additional","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Ceausu","sequence":"additional","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clas","family":"Une","sequence":"additional","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Levitsky","sequence":"additional","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Wigzell","sequence":"additional","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,5,1]]},"reference":[{"key":"2026020213183778300_R1","first-page":"841","volume-title":"J. 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