{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:49:05Z","timestamp":1793411345470,"version":"4.5.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this investigation, we have examined the integrated relationship between IL-13, IL-4, and IL-5 for the development of airways hyperreactivity (AHR) in a model of asthma in BALB\/c mice. Sensitization and aeroallergen challenge of both wild-type (WT) and IL-13 gene-targeted (IL-13\u2212\/\u2212) mice induced allergic disease that was characterized by pulmonary eosinophilia and AHR to \u03b2-methacholine. Although these responses in IL-13\u2212\/\u2212 mice were heightened compared with WT, they could be reduced to the level in nonallergic mice by the concomitant neutralization of IL-4. Mice in which both IL-4 and IL-13 were depleted displayed a marked reduction in tissue eosinophils, despite the development of a blood eosinophilia. Similar neutralization of IL-4 in WT mice only partially reduced AHR with no effect on tissue eosinophilia. In addition, neutralization of IL-5 in IL-13\u2212\/\u2212 mice, but not in WT mice, inhibited AHR, suggesting that tissue eosinophilia is linked to the mechanism underlying AHR only in the absence of IL-13. Additionally, mucus hypersecretion was attenuated in IL-13\u2212\/\u2212 mice, despite the persistence of AHR. Taken together, our data suggest both a modulatory role for IL-13 during sensitization and a proinflammatory role during aeroallergen challenge. The latter process appears redundant with respect to IL-4.<\/jats:p>","DOI":"10.4049\/jimmunol.165.1.108","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:07:57Z","timestamp":1398038877000},"page":"108-113","source":"Crossref","is-referenced-by-count":237,"title":["Integrated Signals Between IL-13, IL-4, and IL-5 Regulate Airways Hyperreactivity"],"prefix":"10.1093","volume":"165","author":[{"given":"Dianne C","family":"Webb","sequence":"first","affiliation":[{"name":"Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N J","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratory of Molecular Biology , Cambridge ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aulikki M L","family":"Koskinen","sequence":"additional","affiliation":[{"name":"Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe\u0308rg","family":"Mattes","sequence":"additional","affiliation":[{"name":"Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S","family":"Foster","sequence":"additional","affiliation":[{"name":"Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"2025032907425792200_R1","first-page":"434","volume-title":"Am. Rev. Respir. Dis.","year":"1990"},{"key":"2025032907425792200_R2","first-page":"295","volume-title":"Annu. Rev. Immunol.","year":"1994"},{"key":"2025032907425792200_R3","first-page":"298","volume-title":"N. Engl. J. Med.","year":"1992"},{"key":"2025032907425792200_R4","first-page":"935","volume-title":"J. Allergy Clin. Immunol.","year":"1991"},{"key":"2025032907425792200_R5","first-page":"1109","volume-title":"Lancet","year":"1998"},{"key":"2025032907425792200_R6","first-page":"374","volume-title":"Am. Rev. Respir. Dis.","year":"1992"},{"key":"2025032907425792200_R7","first-page":"422","volume-title":"J. Allergy Clin. Immunol.","year":"1990"},{"key":"2025032907425792200_R8","first-page":"637","volume-title":"J. Allergy Clin. Immunol.","year":"1991"},{"key":"2025032907425792200_R9","first-page":"1829","volume-title":"J. Immunol.","year":"1991"},{"key":"2025032907425792200_R10","first-page":"845","volume-title":"Thorax","year":"1993"},{"key":"2025032907425792200_R11","first-page":"109","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2025032907425792200_R12","first-page":"195","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2025032907425792200_R13","first-page":"7821","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1996"},{"key":"2025032907425792200_R14","first-page":"1737","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2025032907425792200_R15","first-page":"2143","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2025032907425792200_R16","first-page":"1501","volume-title":"J. Immunol.","year":"1998"},{"key":"2025032907425792200_R17","first-page":"1329","volume-title":"J. Clin. Invest.","year":"1997"},{"key":"2025032907425792200_R18","first-page":"73","volume-title":"Clin. Exp. Allergy","year":"1994"},{"key":"2025032907425792200_R19","first-page":"245","volume-title":"Nature","year":"1993"},{"key":"2025032907425792200_R20","first-page":"3813","volume-title":"J. Immunol.","year":"1998"},{"key":"2025032907425792200_R21","first-page":"939","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2025032907425792200_R22","first-page":"1537","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2025032907425792200_R23","first-page":"L253","volume-title":"Am. J. Physiol.","year":"1997"},{"key":"2025032907425792200_R24","first-page":"2261","volume-title":"Science","year":"1998"},{"key":"2025032907425792200_R25","first-page":"1283","volume-title":"Am. J. Respir. Crit. Care Med.","year":"1999"},{"key":"2025032907425792200_R26","first-page":"2258","volume-title":"Science","year":"1998"},{"key":"2025032907425792200_R27","first-page":"165","volume-title":"J. Allergy Clin. Immunol.","year":"1998"},{"key":"2025032907425792200_R28","first-page":"368","volume-title":"Proc. Assoc. Am. Phys.","year":"1996"},{"key":"2025032907425792200_R29","first-page":"225","volume-title":"Immunol. Lett.","year":"1999"},{"key":"2025032907425792200_R30","first-page":"423","volume-title":"Immunity","year":"1998"},{"key":"2025032907425792200_R31","first-page":"766","volume-title":"Am. J. Respir. Crit. Care Med.","year":"1997"},{"key":"2025032907425792200_R32","first-page":"210","volume-title":"Am. J. Respir. Crit. Care Med.","year":"1998"},{"key":"2025032907425792200_R33","first-page":"2688","volume-title":"J. Immunol.","year":"1995"},{"key":"2025032907425792200_R34","first-page":"5436","volume-title":"J. Immunol.","year":"1993"},{"key":"2025032907425792200_R35","first-page":"1071","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032907425792200_R36","first-page":"1739","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2025032907425792200_R37","first-page":"109","volume-title":"Am. Rev. Respir. Dis.","year":"1992"},{"key":"2025032907425792200_R38","first-page":"2477","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032907425792200_R39","first-page":"1086","volume-title":"J. Immunol.","year":"1992"},{"key":"2025032907425792200_R40","first-page":"60","volume-title":"J. Immunol.","year":"1998"},{"key":"2025032907425792200_R41","first-page":"2332","volume-title":"J. Clin. Invest.","year":"1996"},{"key":"2025032907425792200_R42","first-page":"1871","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2025032907425792200_R43","first-page":"1003","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032907425792200_R44"},{"key":"2025032907425792200_R45","first-page":"1919","volume-title":"Eur. J. Immunol.","year":"1992"},{"key":"2025032907425792200_R46","first-page":"229","volume-title":"Scand. J. Immunol.","year":"1996"},{"key":"2025032907425792200_R47","first-page":"471","volume-title":"Am. J. Respir. Cell Mol. Biol.","year":"1997"},{"key":"2025032907425792200_R48","first-page":"6233","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032907425792200_R49","first-page":"6178","volume-title":"J. Immunol.","year":"1999"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/1\/108\/62729084\/108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/1\/108\/62729084\/108.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T07:52:10Z","timestamp":1743407530000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/165\/1\/108\/8038551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,7,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.165.1.108","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,7]]},"published":{"date-parts":[[2000,7,1]]}}}