{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:56:22Z","timestamp":1791215782872,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although they are known for their capacity to kill infected cells, Ag-specific CD8+ T cells elaborate other effector mechanisms, including TNF and IFN-\u03b3, that contribute to defense against infection. Ag-specific CD8+ T cells rapidly turn ON and turn OFF IFN-\u03b3 production in direct response to Ag contact, presumably to minimize the potential immunopathology that could result from inappropriate secretion of this inflammatory mediator. In this study, we show, using in vitro propagated and directly ex vivo-analyzed Ag-specific CD8+ T cells, that in contrast to Ag-dependent ON\/OFF cycling of IFN-\u03b3 production, the cessation of TNF production by the same IFN-\u03b3 producing cells is rapid and Ag independent.<\/jats:p>","DOI":"10.4049\/jimmunol.165.10.5387","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T23:07:29Z","timestamp":1398121649000},"page":"5387-5391","source":"Crossref","is-referenced-by-count":27,"title":["Cutting Edge: OFF Cycling of TNF Production by Antigen-Specific CD8+ T Cells Is Antigen Independent"],"prefix":"10.1093","volume":"165","author":[{"given":"Vladimir P","family":"Badovinac","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail A","family":"Corbin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Harty","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"},{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,11,15]]},"reference":[{"key":"2026020213171885700_R1","first-page":"275","volume-title":"Annu. 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