{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:57:08Z","timestamp":1784894228874,"version":"3.55.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As Th1 and Th2 cytokines, IFN-\u03b3\/\u03b1 and IL-4 counterregulate diverse immune functions. In particular, IFN-\u03b3 and IFN-\u03b1 have been reported to markedly suppress the IL-4-induced IgE production and type II IgE receptor (Fc\u03b5RII\/CD23) expression. Because modulation of IL-4R may be an important mechanism in the regulation of IL-4 response, we have investigated the effect of IFN-\u03b3\/\u03b1 on IL-4R expression and signal transduction mechanisms involved in this process. In human mononuclear cells and B cells isolated from tonsil or peripheral blood, IL-4 up-regulates IL-4R(\u03b1) expression at surface protein and mRNA levels, and the IL-4-induced IL-4R(\u03b1) is significantly down-regulated by both IFN-\u03b3 and IFN-\u03b1 to a similar extent. The inhibitory effects of IFN-\u03b3\/\u03b1 on the IL-4R mRNA expression require a lag period of about 8 h, and are sensitive to cycloheximide treatment, which suggests that the suppressive effect of IFNs on IL-4R gene expression is a secondary response requiring de novo synthesis of IFN-induced factors. Under such conditions that the inhibitory effects of IFNs are observed, IFNs do not affect the IL-4-induced STAT6 activation and IL-4R transcription, as analyzed by EMSA and nuclear run-on assays, respectively. Subsequently, mRNA stability studies have indicated that the action of IFN-\u03b3\/\u03b1 is primarily mediated by an accelerated decay of IL-4-induced IL-4R mRNA. Thus, it appears that, as already shown in the case of the IL-4-induced Fc\u03b5RII regulation, posttranscriptional inhibition of IL-4-inducible genes by mRNA destabilization is a common mechanism by which type I and II IFNs antagonize the IL-4 response in human immune cells.<\/jats:p>","DOI":"10.4049\/jimmunol.165.10.5472","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T23:07:29Z","timestamp":1398121649000},"page":"5472-5479","source":"Crossref","is-referenced-by-count":69,"title":["IFN-\u03b3 and IFN-\u03b1 Posttranscriptionally Down-Regulate the IL-4-Induced IL-4 Receptor Gene Expression"],"prefix":"10.1093","volume":"165","author":[{"given":"Eui-Young","family":"So","sequence":"first","affiliation":[{"name":"Department of Biological Science and Institute for Basic Science, SungKyunKwan University , Suwon ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Institute for Basic Science, SungKyunKwan University , Suwon ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choong-Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Institute for Basic Science, SungKyunKwan University , Suwon ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,11,15]]},"reference":[{"key":"2026020213151036400_R1","first-page":"138","volume-title":"Immunol. Today","year":"1996"},{"key":"2026020213151036400_R2","first-page":"297","volume-title":"Annu. Rev. Immunol.","year":"1997"},{"key":"2026020213151036400_R3","first-page":"944","volume-title":"Science","year":"1987"},{"key":"2026020213151036400_R4","first-page":"880","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1988"},{"key":"2026020213151036400_R5"},{"key":"2026020213151036400_R6","first-page":"1283","volume-title":"J. Immunol.","year":"1992"},{"key":"2026020213151036400_R7","first-page":"3046","volume-title":"J. Immunol.","year":"1990"},{"key":"2026020213151036400_R8","first-page":"149","volume-title":"J. Exp. Med.","year":"1987"},{"key":"2026020213151036400_R9","first-page":"134","volume-title":"J. Immunol.","year":"1989"},{"key":"2026020213151036400_R10","first-page":"1859","volume-title":"Blood","year":"1991"},{"key":"2026020213151036400_R11","first-page":"701","volume-title":"Annu. Rev. Immunol.","year":"1999"},{"key":"2026020213151036400_R12","first-page":"1655","volume-title":"J. Exp. Med.","year":"1993"},{"key":"2026020213151036400_R13","first-page":"6567","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020213151036400_R14","first-page":"189","volume-title":"Allergy","year":"1993"},{"key":"2026020213151036400_R15","first-page":"129","volume-title":"Mol. Immunol.","year":"1990"},{"key":"2026020213151036400_R16","first-page":"515","volume-title":"Int. Immunol.","year":"1994"},{"key":"2026020213151036400_R17","first-page":"301","volume-title":"Mol. Immunol.","year":"1993"},{"key":"2026020213151036400_R18","first-page":"83","volume-title":"J. Biochem. Mol. Biol.","year":"1998"},{"key":"2026020213151036400_R19","first-page":"551","volume-title":"Eur. J. Immunol.","year":"1990"},{"key":"2026020213151036400_R20","first-page":"199","volume-title":"Pediatr. Nephrol.","year":"1999"},{"key":"2026020213151036400_R21","first-page":"239","volume-title":"Mol. Immunol.","year":"1998"},{"key":"2026020213151036400_R22","first-page":"1350","volume-title":"EMBO J.","year":"1994"},{"key":"2026020213151036400_R23","first-page":"156","volume-title":"Anal. Biochem.","year":"1987"},{"key":"2026020213151036400_R24","first-page":"8922","volume-title":"J. Biol. Chem.","year":"1989"},{"key":"2026020213151036400_R25","first-page":"1376","volume-title":"J. Immunol.","year":"1988"},{"key":"2026020213151036400_R26","first-page":"407","volume-title":"Cytokine","year":"1994"},{"key":"2026020213151036400_R27","first-page":"667","volume-title":"Eur. J. Biochem.","year":"1996"},{"key":"2026020213151036400_R28","first-page":"75","volume-title":"Cytokine","year":"1998"},{"key":"2026020213151036400_R29","first-page":"608","volume-title":"Blood","year":"1994"},{"key":"2026020213151036400_R30","first-page":"621","volume-title":"Annu. Rev. Biochem.","year":"1995"},{"key":"2026020213151036400_R31","first-page":"293","volume-title":"Annu. Rev. Immunol.","year":"1998"},{"key":"2026020213151036400_R32","first-page":"8221","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1988"},{"key":"2026020213151036400_R33","first-page":"6984","volume-title":"J. Biol. Chem.","year":"1989"},{"key":"2026020213151036400_R34","first-page":"25555","volume-title":"J. Biol. Chem.","year":"1996"},{"key":"2026020213151036400_R35","first-page":"1880","volume-title":"Science","year":"1993"},{"key":"2026020213151036400_R36","first-page":"163","volume-title":"FEBS Lett.","year":"1997"},{"key":"2026020213151036400_R37","first-page":"948","volume-title":"Biochem. Biophys. Res. Commun.","year":"1986"},{"key":"2026020213151036400_R38","first-page":"390","volume-title":"Cell. Immunol.","year":"1983"},{"key":"2026020213151036400_R39","first-page":"4513","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020213151036400_R40","first-page":"307","volume-title":"J. Leukocyte Biol.","year":"1999"},{"key":"2026020213151036400_R41","first-page":"917","volume-title":"Nature","year":"1997"},{"key":"2026020213151036400_R42","first-page":"921","volume-title":"Nature","year":"1997"},{"key":"2026020213151036400_R43","first-page":"924","volume-title":"Nature","year":"1997"},{"key":"2026020213151036400_R44","first-page":"5777","volume-title":"Mol. Cell. Biol.","year":"1995"},{"key":"2026020213151036400_R45","first-page":"659","volume-title":"Cell","year":"1986"},{"key":"2026020213151036400_R46","first-page":"777","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1990"},{"key":"2026020213151036400_R47","first-page":"861","volume-title":"J. Exp. Med.","year":"1990"},{"key":"2026020213151036400_R48","first-page":"414","volume-title":"Nature","year":"1981"},{"key":"2026020213151036400_R49","first-page":"1030","volume-title":"Science","year":"1981"},{"key":"2026020213151036400_R50","first-page":"968","volume-title":"J. Allergy Clin. Immunol.","year":"1998"},{"key":"2026020213151036400_R51","first-page":"431","volume-title":"J. Biochem. Mol. Biol.","year":"1997"},{"key":"2026020213151036400_R52","first-page":"493","volume-title":"Mol. Cell.","year":"1995"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/10\/5472\/62729369\/5472.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/10\/5472\/62729369\/5472.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:24:54Z","timestamp":1770056694000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/165\/10\/5472\/8039358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2000,11,15]]},"published-print":{"date-parts":[[2000,11,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.165.10.5472","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,11]]},"published":{"date-parts":[[2000,11]]}}}