{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:12:34Z","timestamp":1791213154379,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-17 is a newly discovered cytokine implicated in the regulation of hemopoiesis and inflammation. Because IL-17 production is restricted to activated T lymphocytes, the effects exerted by IL-17 may help one to understand the contribution of T cells to the inflammatory response. We investigated the role of IL-17 in leukocyte recruitment into the peritoneal cavity. Leukocyte infiltration in vivo was assessed in BALB\/Cj mice. Effects of IL-17 on chemokine generation in vitro were examined in human peritoneal mesothelial cells (HPMC). Administration of IL-17 i.p. resulted in a selective recruitment of neutrophils into the peritoneum and increased levels of KC chemokine (murine homologue of human growth-related oncogene \u03b1 (GRO\u03b1). Pretreatment with anti-KC Ab significantly reduced the IL-17-driven neutrophil accumulation. Primary cultures of HPMC expressed IL-17 receptor mRNA. Exposure of HPMC to IL-17 led to a dose- and time-dependent induction of GRO\u03b1 mRNA and protein. Combination of IL-17 together with TNF-\u03b1 resulted in an increased stability of GRO\u03b1 mRNA and synergistic release of GRO\u03b1 protein. Anti-IL-17 Ab blocked the effects of IL-17 in vitro and in vivo. IL-17 is capable of selectively recruiting neutrophils into the peritoneal cavity via the release of neutrophil-specific chemokines from the peritoneal mesothelium.<\/jats:p>","DOI":"10.4049\/jimmunol.165.10.5814","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T23:07:29Z","timestamp":1398121649000},"page":"5814-5821","source":"Crossref","is-referenced-by-count":246,"title":["IL-17 Stimulates Intraperitoneal Neutrophil Infiltration Through the Release of GRO\u03b1 Chemokine from Mesothelial Cells"],"prefix":"10.1093","volume":"165","author":[{"given":"Janusz","family":"Witowski","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, University Medical School , Poznan ,","place":["Poland"]},{"name":"Department of Nephrology and Medical Intensive Care, Universita\u0308tsklinikum Charite\u0301, Campus Virchow-Klinikum, Humboldt-Universita\u0308t zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Pawlaczyk","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University Medical School , Poznan ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Breborowicz","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University Medical School , Poznan ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Scheuren","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Universita\u0308tsklinikum Charite\u0301, Campus Virchow-Klinikum, Humboldt-Universita\u0308t zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Kuzlan-Pawlaczyk","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University Medical School , Poznan ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Wisniewska","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University Medical School , Poznan ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Polubinska","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University Medical School , Poznan ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Friess","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplant Surgery, University of Bern , Inselspital, Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard M","family":"Gahl","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Universita\u0308tsklinikum Charite\u0301, Campus Virchow-Klinikum, Humboldt-Universita\u0308t zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Frei","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Universita\u0308tsklinikum Charite\u0301, Campus Virchow-Klinikum, Humboldt-Universita\u0308t zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Jo\u0308rres","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care, Universita\u0308tsklinikum Charite\u0301, Campus Virchow-Klinikum, Humboldt-Universita\u0308t zu Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,11,15]]},"reference":[{"key":"2026020213192025200_R1","first-page":"S24","volume-title":"Peritoneal Dial. Int.","year":"1995"},{"key":"2026020213192025200_R2","first-page":"S58","volume-title":"Kidney Int. Suppl.","year":"1994"},{"key":"2026020213192025200_R3","first-page":"373","volume-title":"Nephron","year":"1999"},{"key":"2026020213192025200_R4","first-page":"S273","volume-title":"Peritoneal Dial. Int.","year":"1993"},{"key":"2026020213192025200_R5","first-page":"2626","volume-title":"Eur. J. Immunol.","year":"1995"},{"key":"2026020213192025200_R6","first-page":"157","volume-title":"Scand. J. Immunol.","year":"1996"},{"key":"2026020213192025200_R7","first-page":"641","volume-title":"Kidney Int.","year":"1993"},{"key":"2026020213192025200_R8","first-page":"1386","volume-title":"Kidney Int.","year":"1996"},{"key":"2026020213192025200_R9","first-page":"521","volume-title":"Annu. Rev. Immunol.","year":"1994"},{"key":"2026020213192025200_R10","first-page":"1189","volume-title":"Lancet","year":"1991"},{"key":"2026020213192025200_R11","first-page":"1031","volume-title":"Br. J. Surg.","year":"1996"},{"key":"2026020213192025200_R12","first-page":"749","volume-title":"Annu. Rev. Immunol.","year":"1997"},{"key":"2026020213192025200_R13","first-page":"475","volume-title":"Kidney Int.","year":"1994"},{"key":"2026020213192025200_R14","first-page":"541","volume-title":"Int. Rev. Immunol.","year":"1998"},{"key":"2026020213192025200_R15","first-page":"5483","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020213192025200_R16","first-page":"611","volume-title":"J. Interferon Cytokine Res.","year":"1996"},{"key":"2026020213192025200_R17","first-page":"2593","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020213192025200_R18","first-page":"841","volume-title":"Cytokine","year":"1998"},{"key":"2026020213192025200_R19","first-page":"257","volume-title":"Cytokine","year":"1999"},{"key":"2026020213192025200_R20","first-page":"794","volume-title":"Cytokine","year":"1997"},{"key":"2026020213192025200_R21","first-page":"811","volume-title":"Immunity","year":"1995"},{"key":"2026020213192025200_R22","first-page":"366","volume-title":"J. Clin. Immunol.","year":"1997"},{"key":"2026020213192025200_R23","first-page":"409","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020213192025200_R24","first-page":"51","volume-title":"Immunol. Lett.","year":"1998"},{"key":"2026020213192025200_R25","first-page":"3513","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020213192025200_R26","first-page":"27467","volume-title":"J. Biol. Chem.","year":"1998"},{"key":"2026020213192025200_R27","first-page":"645","volume-title":"J. Invest. Dermatol.","year":"1998"},{"key":"2026020213192025200_R28","first-page":"1526","volume-title":"J. Am. Soc. Nephrol.","year":"1998"},{"key":"2026020213192025200_R29","first-page":"5337","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020213192025200_R30","first-page":"108","volume-title":"J. Leukocyte Biol.","year":"1998"},{"key":"2026020213192025200_R31","first-page":"1563","volume-title":"Kidney Int.","year":"1990"},{"key":"2026020213192025200_R32","first-page":"1876","volume-title":"Am. J. Pathol.","year":"1993"},{"key":"2026020213192025200_R33","first-page":"119","volume-title":"Cytokine","year":"1997"},{"key":"2026020213192025200_R34","first-page":"1214","volume-title":"Gastroenterology","year":"1997"},{"key":"2026020213192025200_R35","first-page":"494","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020213192025200_R36","first-page":"5016","volume-title":"Mol. Cell Biol.","year":"1991"},{"key":"2026020213192025200_R37","first-page":"1687","volume-title":"Nucleic Acids Res.","year":"1984"},{"key":"2026020213192025200_R38","first-page":"4876","volume-title":"Cancer Res.","year":"1996"},{"key":"2026020213192025200_R39","first-page":"2704","volume-title":"Cancer Res.","year":"1993"},{"key":"2026020213192025200_R40","first-page":"1846","volume-title":"Gastroenterology","year":"1993"},{"key":"2026020213192025200_R41","first-page":"2054","volume-title":"Dig. Dis. Sci.","year":"1997"},{"key":"2026020213192025200_R42","first-page":"6453","volume-title":"Nucleic Acids Res.","year":"1990"},{"key":"2026020213192025200_R43","first-page":"909","volume-title":"Blood","year":"1997"},{"key":"2026020213192025200_R44","first-page":"6383","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020213192025200_R45","first-page":"2347","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020213192025200_R46","first-page":"1423","volume-title":"Am. J. Respir. Crit. Care Med.","year":"1999"},{"key":"2026020213192025200_R47","first-page":"1685","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020213192025200_R48","first-page":"6048","volume-title":"J. Immunol.","year":"1995"},{"key":"2026020213192025200_R49","first-page":"3847","volume-title":"Infect. Immun.","year":"1997"},{"key":"2026020213192025200_R50","first-page":"133","volume-title":"Inflammation","year":"1995"},{"key":"2026020213192025200_R51","first-page":"9","volume-title":"Cytokine Growth Factor Rev.","year":"1998"},{"key":"2026020213192025200_R52","first-page":"1202","volume-title":"J. Infect. Dis.","year":"1993"},{"key":"2026020213192025200_R53","first-page":"2170","volume-title":"Kidney Int.","year":"1998"},{"key":"2026020213192025200_R54","first-page":"4206","volume-title":"Infect. Immun.","year":"1995"},{"key":"2026020213192025200_R55","first-page":"270","volume-title":"Clin. Exp. Immunol.","year":"1998"},{"key":"2026020213192025200_R56","first-page":"1050","volume-title":"Arthritis Rheum.","year":"1997"},{"key":"2026020213192025200_R57","first-page":"28","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020213192025200_R58","first-page":"963","volume-title":"Arthritis Rheum.","year":"1999"},{"key":"2026020213192025200_R59","first-page":"1345","volume-title":"J. Clin. Invest.","year":"1999"},{"key":"2026020213192025200_R60","first-page":"577","volume-title":"J. Immunol.","year":"1999"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/10\/5814\/62732508\/5814.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/10\/5814\/62732508\/5814.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:32:10Z","timestamp":1770057130000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/165\/10\/5814\/8039814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":60,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2000,11,15]]},"published-print":{"date-parts":[[2000,11,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.165.10.5814","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,11]]},"published":{"date-parts":[[2000,11]]}}}