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CD27high\/CD38+\/CD19dim\/surface Iglow\/CD20\u2212\/CD138+ plasma cells were found at high frequencies in active but not inactive SLE patients. Upon immunosuppressive therapy, CD27high plasma cells and naive CD27\u2212 B cells were markedly decreased in the peripheral blood. Mutational analysis of V gene rearrangements of individual B cells confirmed that CD27+ B cells coexpressing IgD were memory B cells preferentially using VH3 family members with multiple somatic mutations. CD27high plasma cells showed a similar degree of somatic hypermutation, but preferentially employed VH4 family members. These results indicate that there are profound abnormalities in the various B cell compartments in SLE that respond differently to immunosuppressive therapy.<\/jats:p>","DOI":"10.4049\/jimmunol.165.10.5970","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T23:07:29Z","timestamp":1398121649000},"page":"5970-5979","source":"Crossref","is-referenced-by-count":549,"title":["Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus"],"prefix":"10.1093","volume":"165","author":[{"given":"Marcus","family":"Odendahl","sequence":"first","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum Berlin, Charite University Hospital , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Jacobi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charite University Hospital , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Hansen","sequence":"additional","affiliation":[{"name":"Outpatients\u2019 Department, Charite University Hospital , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Feist","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charite University Hospital , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Hiepe","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum Berlin, Charite University Hospital , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd R","family":"Burmester","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charite University Hospital , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E","family":"Lipsky","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoscletal and Skin Diseases; National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Radbruch","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum Berlin, Charite University Hospital , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Do\u0308rner","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Charite University Hospital , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,11,15]]},"reference":[{"key":"2026020213154522600_R1","first-page":"1","volume-title":"Ann. 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