{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:17:13Z","timestamp":1793434633270,"version":"4.5.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Immunization of mice with the heat shock protein (HSP) gp96 but not control proteins leads to 5- to 7-fold enlargement of draining lymph nodes (LNs) resulting from accumulation of large numbers of mature CD11c+ cells, but not T or B lymphocytes in them. The increase in size and cellularity is time-dependent; the draining LNs reach their peak size between 12 and 24 h after injection and regress to their normal size between 48 and 72 h after injection. The increment is elicited specifically in the draining LN but not in other LNs. This observation uncovers a novel aspect of HSP-APC interaction and adds to the mechanistic explanation for the unusually high immunogenicity of HSP-peptide complexes.<\/jats:p>","DOI":"10.4049\/jimmunol.165.11.6029","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T02:44:50Z","timestamp":1398134690000},"page":"6029-6035","source":"Crossref","is-referenced-by-count":157,"title":["Cutting Edge: Heat Shock Protein gp96 Induces Maturation and Migration of CD11c+ Cells In Vivo"],"prefix":"10.1093","volume":"165","author":[{"given":"Robert J","family":"Binder","sequence":"first","affiliation":[{"name":"Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstin M","family":"Anderson","sequence":"additional","affiliation":[{"name":"Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreyashi","family":"Basu","sequence":"additional","affiliation":[{"name":"Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod K","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2025032908192953300_R1","first-page":"3143","volume-title":"EMBO J.","year":"1993"},{"key":"2025032908192953300_R2","first-page":"1391","volume-title":"J. Exp. Med.","year":"1993"},{"key":"2025032908192953300_R3","first-page":"6135","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1996"},{"key":"2025032908192953300_R4","first-page":"13","volume-title":"J. Immunol. Methods","year":"1997"},{"key":"2025032908192953300_R5","first-page":"117","volume-title":"Science","year":"1997"},{"key":"2025032908192953300_R6","first-page":"103","volume-title":"Curr. Opin. Immunol.","year":"1998"},{"key":"2025032908192953300_R7","first-page":"1315","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2025032908192953300_R8","first-page":"151","volume-title":"Nat. Immunol.","year":"2000"},{"key":"2025032908192953300_R9"},{"key":"2025032908192953300_R10","first-page":"2211","volume-title":"Eur. J. Immunol.","year":"2000"},{"key":"2025032908192953300_R11","first-page":"13","volume-title":"J. Immunol.","year":"2000"},{"key":"2025032908192953300_R12","first-page":"416","volume-title":"Int. J. Cancer","year":"1984"},{"key":"2025032908192953300_R13","first-page":"3407","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1986"},{"key":"2025032908192953300_R14","first-page":"657","volume-title":"Immunity","year":"1998"},{"key":"2025032908192953300_R15","first-page":"1585","volume-title":"Science","year":"1995"},{"key":"2025032908192953300_R16","first-page":"611","volume-title":"M. Exp. Med.","year":"1999"},{"key":"2025032908192953300_R17","first-page":"2011","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2025032908192953300_R18","first-page":"33","volume-title":"J. Leukocyte Biol.","year":"1999"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/11\/6029\/62732242\/6029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/165\/11\/6029\/62732242\/6029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T09:12:11Z","timestamp":1743412331000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/165\/11\/6029\/8038830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,1]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2000,12,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.165.11.6029","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,12]]},"published":{"date-parts":[[2000,12,1]]}}}