{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:22:06Z","timestamp":1774567326810,"version":"3.50.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u03b3\u03b4 T lymphocytes have been shown to regulate immune responses in diverse experimental systems. Because distinct \u03b3\u03b4 T cell subsets, as defined by the usage of certain TCR V genes, preferentially respond in various diseases and disease models, we have hypothesized that the various \u03b3\u03b4 T cell subsets carry out different functions. To test this, we compared one particular \u03b3\u03b4 T cell subset, the V\u03b31+ subset, which represents a major \u03b3\u03b4 T cell type in the lymphoid organs and blood of mice, to other subsets and to \u03b3\u03b4 T cells as a whole. Using Listeria monocytogenes infection as an infectious disease model, we found that bacterial containment improves in mice depleted of V\u03b31+ \u03b3\u03b4 T cells, albeit mice lacking all \u03b3\u03b4 T cells are instead impaired in their ability to control Listeria expansion. Our findings indicate that V\u03b31+ \u03b3\u03b4 T cells reduce the ability of the innate immune system to destroy Listeria, even though other \u03b3\u03b4 T cells as a whole promote clearance of this pathogen.<\/jats:p>","DOI":"10.4049\/jimmunol.165.11.6472","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T22:44:50Z","timestamp":1398120290000},"page":"6472-6479","source":"Crossref","is-referenced-by-count":53,"title":["Depletion of a \u03b3\u03b4 T Cell Subset Can Increase Host Resistance to a Bacterial Infection"],"prefix":"10.1093","volume":"165","author":[{"given":"Rebecca L","family":"O\u2019Brien","sequence":"first","affiliation":[{"name":"Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206 and Department of Immunology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206 and Department of Immunology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally A","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, Kyoto University Faculty of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willi K","family":"Born","sequence":"additional","affiliation":[{"name":"Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206 and Department of Immunology, University of Colorado Health Sciences Center , Denver, CO 80262"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2026020213110458800_R1","first-page":"53","volume-title":"Nature","year":"1993"},{"key":"2026020213110458800_R2","first-page":"3101","volume-title":"J. 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