{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:15:13Z","timestamp":1761059713257,"version":"3.40.3"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the present report, we have studied the potential of naive and activated effector CD8+ T cells to function as anti-tumor T cells to a solid tumor using OVA-specific T cells from TCR-transgenic OT-I mice. Adoptive transfer of naive OT-I T cells into tumor-bearing syngeneic mice did not inhibit tumor cell growth. The adoptively transferred OT-I T cells did not proliferate in lymphoid tissue of tumor-bearing mice and were not anergized by the tumor. In contrast, adoptive transfer of preactivated OT-I CTL inhibited tumor growth in a dose-dependent manner, indicating that E.G7 was susceptible to immune effector cells. Importantly, naive OT-I T cells proliferated and elicited an anti-tumor response if they were adoptively transferred into normal or CD4-deficient mice that were then vaccinated with GM-CSF-induced bone marrow-derived OVA-pulsed APC. Collectively, these data indicate that even though naive tumor-specific T cells are present at a relatively high fraction they remain ignorant of the tumor and demonstrate that a CD8-mediated anti-tumor response can be induced by Ag-pulsed APC without CD4 T cell help.<\/jats:p>","DOI":"10.4049\/jimmunol.165.12.6731","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T23:33:40Z","timestamp":1398036820000},"page":"6731-6737","source":"Crossref","is-referenced-by-count":30,"title":["Reversal of CD8+ T Cell Ignorance and Induction of Anti-Tumor Immunity by Peptide-Pulsed APC"],"prefix":"10.1093","volume":"165","author":[{"given":"Nava","family":"Dalyot-Herman","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Division of Surgical Oncology, University of Miami School of Medicine , Miami, FL 33101"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver F","family":"Bathe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology, University of Miami School of Medicine , Miami, FL 33101"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R","family":"Malek","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Division of Surgical Oncology, University of Miami School of Medicine , Miami, FL 33101"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,12,15]]},"reference":[{"first-page":"337","volume-title":"Annu. 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