{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:42:44Z","timestamp":1773268964471,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>B cells are known to play an important role in the pathogenesis of several autoimmune diseases. NOD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) and anti-mouse thyroglobulin (MTg) autoantibodies, the levels of which correlate closely with the severity of thyroid lesions. NOD.H-2h4 mice genetically deficient in B cells (NOD.K\u03bcnull) or rendered B cell-deficient by treatment from birth with anti-IgM develop minimal SAT. B cells were required some time in the first 4\u20136 wk after birth, because NOD.K\u03bcnull or NOD.H-2h4 mice did not develop SAT when they were reconstituted with B cells as adults. The requirement for B cells was apparently not solely to produce anti-MTg autoantibodies, because passive transfer of anti-MTg Ab did not enable B cell-deficient mice to develop SAT, and mice given B cells as adults produced autoantibodies but did not develop SAT. B cell-deficient mice developed SAT if their T cells developed from bone marrow precursors in the presence of B cells. Because B cells are required early in life and their function cannot be replaced by anti-MTg autoantibodies, B cells may be required for the activation or selection of autoreactive T cells. These autoreactive T cells are apparently unable to respond to Ag if B cells are absent in the first 4\u20136 wk after birth.<\/jats:p>","DOI":"10.4049\/jimmunol.165.12.7262","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:33:40Z","timestamp":1398022420000},"page":"7262-7269","source":"Crossref","is-referenced-by-count":58,"title":["Early Requirement for B Cells for Development of Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice"],"prefix":"10.1093","volume":"165","author":[{"given":"Helen","family":"Braley-Mullen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Missouri , Columbia, MO 65212"},{"name":"Department of Medical Microbiology and Immunology, University of Missouri , Columbia, MO 65212"},{"name":"Veteran\u2019s Administration Research Service , Columbia, MO 65212"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiguang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Missouri , Columbia, MO 65212"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,12,15]]},"reference":[{"key":"2026020213132128400_R1","first-page":"263","volume-title":"Adv. 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