{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:50:14Z","timestamp":1792741814206,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intranasal infection of mice with the murine \u03b3-herpesvirus MHV-68 results in an acute lytic infection in the lung, followed by the establishment of lifelong latency. Development of an infectious mononucleosis-like syndrome correlates with the establishment of latency and is characterized by splenomegaly and the appearance of activated CD8+ T cells in the peripheral blood. Interestingly, a large population of activated CD8+ T cells in the peripheral blood expresses the V\u03b24+ element in their TCR. In this report we show that MHV-68 latency in the spleen after intranasal infection is harbored in three APC types: B cells, macrophages, and dendritic cells. Surprisingly, since latency has not previously been described in dendritic cells, these cells harbored the highest frequency of latent virus. Among B cells, latency was preferentially associated with activated B cells expressing the phenotype of germinal center B cells, thus formally linking the previously reported association of latency gene expression and germinal centers to germinal center B cells. Germinal center formation, however, was not required for the establishment of latency. Significantly, although three cell types were latently infected, the ability to stimulate V\u03b24+CD8+ T cell hybridomas was limited to latently infected, activated B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.165.2.1074","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T03:02:33Z","timestamp":1398135753000},"page":"1074-1081","source":"Crossref","is-referenced-by-count":244,"title":["Latent Murine \u03b3-Herpesvirus Infection Is Established in Activated B Cells, Dendritic Cells, and Macrophages"],"prefix":"10.1093","volume":"165","author":[{"given":"Emilio","family":"Flan\u0303o","sequence":"first","affiliation":[{"name":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"},{"name":"Program in Viral Oncogenesis and Tumor Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Mazher","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Virology and Molecular Biology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"},{"name":"Program in Viral Oncogenesis and Tumor Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery T","family":"Sample","sequence":"additional","affiliation":[{"name":"Department of Virology and Molecular Biology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"},{"name":"Program in Viral Oncogenesis and Tumor Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"},{"name":"Department of Pathology, University of Tennessee , Memphis, TN 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Woodland","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"},{"name":"Program in Viral Oncogenesis and Tumor Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"},{"name":"Department of Pathology, University of Tennessee , Memphis, TN 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia A","family":"Blackman","sequence":"additional","affiliation":[{"name":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"},{"name":"Program in Viral Oncogenesis and Tumor Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN 38105"},{"name":"Department of Pathology, University of Tennessee , Memphis, TN 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,7,15]]},"reference":[{"key":"2025032907473771500_R1","first-page":"560","volume-title":"Curr. 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